Mass Spectrometry & Spectroscopy 17 Rapid, Direct Mass Spectrometry Characterisation of Difficult Samples
The ionRocket from BioChromato Inc is a temperature-heating device for direct thermal desorption and pyrolysis of samples, prior to ionisation and analysis by mass spectrometry.
Direct Analysis in Real Time Mass Spectrometry (DART-MS) is a proven technique that enables rapid analysis of both solid and liquid samples under standard laboratory conditions without sample preparation. However, certain polymers, cosmetic powders and forensic materials are difficult to analyse using DART-MS due to the varying volatility of substituents in these complex samples. Even insoluble samples can be measured using the ionRocket/DART-MS set-up without treatment.
To overcome these challenges, BioChromato developed an innovative sample introduction device (ionRocket), which gradually heats a sample placed directly beneath the DART-MS gas stream. Gradient heating of the sample before ionisation creates time/ temperature resolved mass spectra, separating species both by their thermal desorption profiles and mass to charge ratio (m/z).
ionRocket generates a temperature gradient from ambient up to as high as 600ºC in just a few minutes. This allows compounds in your samples to be sublimated, vaporised, or pyrolysed according to their volatility, and then introduced into the DART-MS gas stream. Because the ionRocket offers the option to weigh samples prior to analysis this results in reproducible MS intensity, allowing calibration curves of analyte amount versus peak intensity to be calculated.
Data obtained from ionRocket yields another axis of data (time/temperature) beyond that obtained from normal DART-MS analysis. Species desorb in order of their volatility along the temperature gradient, and therefore are separated in time. The data produced resembles that of an LC-MS or GC-MS chromatogram, consisting of temperature/time, m/z, and intensity. This can separate rare from abundant species, making them easier to detect.
Watch a video introduction to ionRocket operation:
ilmt.co/PL/rWMo More information online:
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First Commercial Browser-Based NMR Processing Application Introduced
ACD/Labs has announced the launch of a new browser-based application - Spectrus JS. This new cross-platform application will work on Windows, macOS, and Linux operating systems to process NMR data from all major NMR instrument vendors.
Spectrus JS (JavaScript) only requires access to a browser and internet connection to make NMR data processing and interpretation possible from anywhere and at any time. Such an application has been missing from the software portfolio available to researchers in the modern laboratory.
Spectrus JS is a part of the ACD/Spectrus product portfolio. It introduces server-side processing for NMR and expands the cloud capabilities of this platform. Spectrus platform supports all types of analytical techniques and is paired with well-proven knowledge management and targeted workflow applications.
“Scientists need convenient access to processing and analysis capabilities. This need has become even more critical in light of global social distancing measures. This new browser-based client application allows for facile access to these processing and analysis capabilities - even when far away from the Spectrometer,” said Andrew Anderson, Vice President Innovation & Informatics Strategy, ACD/Labs.
“ACD/Labs has a rich history in providing advanced software for NMR data processing. Accurate NMR spectral prediction is the foundation of any advanced NMR data analysis, and our NMR Predictors are universally recognised as the best in the market. Our Structure Elucidator product is second to none in available CASE Expert Systems. With the release of Spectrus JS we are taking these achievements one step further. We are providing the NMR community with the capability to use ACD/Labs’ state-of-the-art processing algorithms in a modern, easy to use interface that is accessible by any device with a browser and Internet access,” commented Dimitris Argyropoulos, NMR Business Manager, ACD/Labs.
More information online:
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Collaboration to Accelerate Next Generation Battery Development Announced
Oxford Instruments has announced a new R&D collaboration has been formed with the University of Oxford’s Department of Materials and the Henry Royce. It will work to accelerate research in future battery technologies by using benchtop Nuclear Magnetic Resonance (NMR) to develop new methods to monitor reactions in battery cells and use this understanding to enhance their performance. It aims to contribute to the UK’s industrial strategy to fight climate change through the development of new technology for net zero-emission vehicles and will contribute to realising practical lifetimes for beyond Li-ion technologies such as the Lithium-Air battery that promises a step-change improvement in energy density.
Researchers will use X-Pulse, Oxford Instruments’ benchtop NMR spectrometer, to characterise the behaviour of a wide range of different elements within novel battery material formulations during electrochemical processes. X-Pulse is the world’s only broadband X-nucleus benchtop NMR spectrometer. Critical to the project is the development of in-operando NMR operation in an inert glovebox environment.
More information online:
ilmt.co/PL/LZYv 54648pr@reply-direct.com
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