Chromatography 27
New Module Enables Automated Method Modelling As a signifi cant expansion of DryLab®
the release of the software’s newest module - the DryLab®
4’s functionalities the team at Molnár-Institute announces Empower Automation.
This module enables automated method modelling on three levels of DryLab’s AQbD-workfl ow: it creates, performs and retrieves input runs, automates the model’s verifi cation and validates its in-silico robustness assessment.
The automated and seamless integration between DryLab® 4 and Waters Empower equips the
chromatographer with an easy-to-use modelling platform. It allows for science-based, fl exible decisions in modelling, mitigated risk, improved analytical throughput and a holistic approach to state-of-the-art method development.
The Empower module generates method sets and runs them in the most economic and ecological order, taking into account subsequent equilibration steps. DryLab®
to adjust the model. Compliant with the recently introduced ICH Q12 guideline for assessing the robustness of an analytical method the new DryLab®
then accesses Empower’s data-stream for additional peak-information on peak shapes (Tf, w0.5) and peak names that can be directly used Empower Automation
further facilitates the R&D process to reduce time between drug discovery and approval by optimising use of instrumentation and determining the most robust method conditions.
The Empower Automation Module further supports peak tracking using MS data where Waters QDa or SQD2 are used. In simple cases a completely automated peak tracking is possible. In other cases, manual peak tracking is supported by displaying mass spectra for selected peaks or plotting single ion traces over the UV chromatograms.
Empower Automation also takes into account Audit Trail settings. Depending on the type of Audit Trail (none, restricted or unrestricted), either a general comment string can be used or the user can select a predefi ned default string for objects created by DryLab.
DryLab®
Ask for a free demo today. More information online:
ilmt.co/PL/mJKp
55324pr@reply-direct.com
Glass Autosampler Vials Virtually Eliminate Surface Activity
Reduced Surface Activity (RSA™) glass autosampler vials are not coated vials and virtually eliminate the adsorption of basic compounds found with all other glass vials. The manufacturing process of RSA™ vials produces vials without surface activity such as basic compound adsorption. Unlike ordinary glass vials, these vials will not produce a pH change with aqueous diluent over time in the vial
and with minimised surface metals, it is excellent for LCMS in that it does not contribute to sodium adducts.
Laboratories testing low abundance analytes such as low dosage form pharmaceuticals, unknown unknowns and natural products will see the greatest benefi t even though all labs will fi nd these vials to have value when repeating runs or investigations must be avoided.
The vials are available from Microsolv in 12x32mm clear and amber with volumes of 2ml, 1.5ml and 300ul.
More information online:
ilmt.co/PL/ZJGm 52069pr@reply-direct.com
Flowmeter for HPLC performance monitoring
• Real-time detection of leakage, pressure drops and flow pulsation
• HPLC pump calibration - easy, fast and reliable
• Highly accurate and non-invasive
Download technical note:
www.testa-analytical.com/
tech.html
TESTA ANALYTICAL SOLUTIONS Sophienstr. 5, 12203 Berlin, Germany
info@testa-analytical.com | +49 30 864 24 076
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