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Combining Freeze Drying and High Pressure Homogenisation for Ultra-Fine Nanocrystal Production
In recent years, nanomedicine has proven to be key in overcoming many of the challenges associated with poorly water-soluble drugs. Decreasing the size of drug particles can increase bioavailability and solubility, as a result of the increased API surface area.
Due to increased bioavailability, a lower amount of API is required, which in turn leads to a more cost-efficient product, with less risks and side effects for the patient.
High pressure homogenisation has long been the favoured method of particle size reduction and is often considered as a first-generation approach. Recently, second-generation approaches have been introduced and these involve a combination of technologies (SmartCrystal processes). One of which is known as the H96 process -the combination of freeze drying, followed by high pressure homogenisation.
The aim is to modify the starting material in such a way, that it can be better broken down by high pressure homogenisation.
Benefits of combinative technology include: faster production of the nanocrystal, by reducing the number of required homogenisation cycles/ passes; higher physical stability; smaller achievable particle size; improved in vivo performance. The H96 process involves initial freeze drying of an organic solution of the poorly water-soluble drug.
Another benefit of the H96 approach is a reduction in the required number of homogenisation cycles/passes to achieve the desired particle size and/or size distribution.
At pilot and production scale, this could bring about significant cost-savings, as a result of reduced processing and labour time, reduced wear rates and machine downtime, all of which improve the overall commercial viability of the process/project.
Biopharma Group supply high pressure homogenisers across the UK & Ireland, as well as the market-leading SP Scientific freeze dryers - all fully supported by their Technical Service Team
Biopharma Group’s experience has been established with more than 3000 projects developed for APIs, biopharmaceuticals, therapeutic delivery systems, PCR reagents, whole organisms, vaccines, blood components, food and nutraceuticals ensuring success in many industrial processes, globally. More information online:
ilmt.co/PL/2XPL
54418pr@reply-direct.com New Ultra Pure Water System Launched
Evoqua Water Technologies has launched a new range of Lab Water systems, equipped with the new electronic dispenser. The new Ultra Clear™ TP ED series consists of ten models, all of which feature the new electronic dispenser allowing precise and easy volume-controlled dispensing of ultra-pure water. The systems supply the highest producible water quality for all laboratory needs, critical test and research environments.
The new and improved software is intuitive and makes dispensing easy without any delay. The polisher models require deionised water with a conductivity of < 20 µS/cm. With 18,2 MΩ-cm (0,055 µS/cm) and a TOC level > 3 ppb, the ultra-pure water exceeds common quality standards.
The Ultra Clear TWF and TWF EDI models can be connected directly to the drinking water network.
With 30l and 60l tank options, the produced ultra-pure water is precisely taken from the electronic dispenser. The highest purity is achieved with the TWF EDI models which feature the IONPURE®
electrodeionization cell.
All models feature the high-resolution, 7” multi-colour touch display whereby all parameters and change intervals can be viewed. A new printer and Modbus interface integrates the data transfer into your existing system.
A high degree of user-friendliness is ensured during installation. The system is delivered ready for operation, it contains all connection hoses, as well as the first module and filter set.
The Ultra Clear TP ED series builds on the best features of the Ultra Clear TP Series, which will no longer be available from January 2022. More information online:
ilmt.co/PL/qzL9
55297pr@reply-direct.com
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