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Highly Reproducible Flow Chemistry Scale-up of Polymerisation Reactions
Uniqsis reports researchers at the Helmholtz-Zentrum Institute of Membrane Research are using a FlowLab Plus flow chemistry system with glass static mixer reactor blocks to synthesise well defined polymers.
Synthesising well defined polymers, with a narrow Molecular Weight distribution, has traditionally been achieved by using anionic polymerisation methodologies. However, precise control of Molecular Weight achieved in this way is accompanied by very high sensitivity to impurities, temperature changes and fast polymerisation rates, which leads to high demands on the process control along with challenging laboratory work. More recently radical polymerisation methods such as the Reversible Addition- Fragmentation chain Transfer (RAFT) polymerisation technique have been the focus of polymer research as alternative methods to synthesise well-defined polymers from a variety of monomers.
In a new paper, published by the Helmholtz Institute, a model-assisted approach to develop and optimise a flow chemistry reaction system for the RAFT polymerisation of MMA is presented. A reaction kinetics and a heat-transfer model were used together with in-line NMR spectroscopy to gain insight into the polymerisation process in order to develop strategies for the process optimisation. A screening method was used to investigate a broad range of different residence times in a single experiment. Adjustments were made to the composition of the reaction mixture, the temperature and the flow chemistry reactor setup.
Download the technical paper 67 to find out how to synthesise well-defined polymers:
Designed by chemists for chemists - FlowLab Plus™ is a versatile modular flow chemistry system built around the Uniqsis Binary Pump™ dual channel reagent delivery system. The system is configured to run both manual and automated flow chemistry reactions. The system may be configured with any combination of up to 4 individual reactor modules. A wide variety of configurations are possible.
To achieve highly reproducible flow chemistry scale-up the control of mixing and temperature is essential, particularly for polymerisation reactions. Precision machined from inert borosilicate glass to withstand a wide temperature range - Glass Static Mixer (GSM) chip reactor blocks from Uniqsis are proven to produce a highly efficient, turbulent mixed reagent stream.
More information online:
ilmt.co/PL/GElG 54977pr@reply-direct.com
Four New Models Extends Adjustable Tip Spacing Pipette Portfolio Four additional variants have been added to Eppendorf’s line-up of Move It®
pipettes. With adjustable cone distances, Move It® plus Move It®
adjustable tip spacing pipettes allow scientists to accelerate and simplify
their workflow when pipetting between different vessel formats such as from tubes to plates. The new electronic Eppendorf Xplorer®
models feature 8 or 12 channels and volume
ranges of 1–20 µL or 5–100 µL respectively. With a minimum tip distance of 4.5 mm they are perfectly suited for the 384-well plate format.
Their unique, tubeless design results in fewer moving fragile parts which improves precision and durability. The pipettes are also autoclavable - increasing user and sample safety. With a 360° rotatable pipette head and an ideal hand balance, Move It® reduce operating stress in the lab.
pipettes are highly ergonomic and
Launched in 2020, the Move It® Choice Awards®
Along with the new Move It®
line-up has already been acknowledged with a Wiley Analytical Science Award 2021 and one of the esteemed Scientists’ 2021 for Best New General Lab Product of 2020. It now covers all dominant volume variants needed for different applications.
variants, Eppendorf have ramped up their production capacities for epT.I.P.S.®
for 384-well pipetting and also available as filter tip. Move It®
pipette). epT.I.P.S.® 384 pipette tips, which are the perfect choice
is available now with 4, 6, 8, and 12 channels, as mechanical or electronic pipette (12-channel variants currently only available as electronic 384 and ep Dualfilter T.I.P.S.®
384 are back in stock.
Learn about Eppendorf 384-well plate pipetting solutions. More information online:
ilmt.co/PL/Ok6y and
ilmt.co/PL/Lg69
54957pr@reply-direct.com
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