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Mass Spectrometry & Spectroscopy 29


Any ambiguity regarding their accurate identification and clear discrimination is easily overcome with XTR spectral processing. Although very similar in their chemical composition and structure, the implementation of XTR spectral processing reveals a Raman peak positioned within the 600–800 cm-1 range in Figure 7 (top) that is unique to acetyl fentanyl.


Summary


MIRA XTR DS is the evolution of handheld Raman spectroscopy. It overcomes the longstanding limitation of fluorescence interference and integrates this capability into one of the most affordable and compact instruments available on the market. Now users can proceed with enhanced confidence in both data quality and the ability to make informed decisions in the field.


References


1. Cadusch, P. J.; Hlaing, M. M.; Wade, S. A.; et al. Fluorescence Background Subtraction from Raman Spectra. J. Raman Spectrosc. 2013, 44 (11), 1587–1595. https://doi.org/10.1002/jrs.4371


2. Wei, D.; Chen, S.; Liu, Q. Review of Fluorescence Suppression Techniques in Raman Spectroscopy. Appl. Spectrosc. Rev. 2015, 50 (5), 387–406. https://doi.org/10.1080/05704928.2014.999936


3. Rojalin, T.; Kurki, L.; Laaksonen, T.; et al. Fluorescence- Suppressed Time-Resolved Raman Spectroscopy of Pharmaceuticals Using Complementary Metal-Oxide Semiconductor (CMOS) Single-Photon Avalanche Diode (SPAD) Detector. Anal. Bioanal. Chem. 2016, 408 (3), 761–774. https://doi.org/10.1007/s00216-015-9156-6


4. Sequentially Shifted Excitation Raman Spectroscopy https://www.spectroscopyonline.com/view/sequentially-shifted- excitation-raman-spectroscopy (accessed 2021-09-08)


5. Conti, C.; Botteon, A.; Bertasa, M.; et al. Portable Sequentially Shifted Excitation Raman Spectroscopy as an Innovative Tool for in Situ Chemical Interrogation of Painted Surfaces. Analyst 2016, 41 (15), 4599–4607. https://doi.org/10.1039/C6AN00753H


6. Albrecht, A. C. On the Theory of Raman Intensities. J. Chem. Phys. 1961, 34 (5), 1476–1484. https://doi.org/10.1063/1.1701032


7. Wilson, E. B.; Decius, J. C.; Cross, P. C.; et al. Molecular Vibrations: The Theory of Infrared and Raman Vibrational Spectra. J. Electrochem. Soc. 1955, 102 (9), 235Ca. https://doi.org/10.1149/1.2430134


8. Li Vigni, M.; Durante, C.; Michelini, S.; et al. Preliminary Assessment of Parmigiano Reggiano Authenticity by Handheld Raman Spectroscopy. Foods Basel Switz. 2020, 9 (11), E1563. https://doi.org/10.3390/foods9111563


9. Metrohm AG. Identification of structurally very similar sugars using a portable Raman spectrometer, Metrohm AG: Herisau, Switzerland, 2015. AN-RS-002


10. Logan, B. G.; Hopkins, D. L.; Schmidtke, L. M.; et al. Authenticating Common Australian Beef Production Systems Using Raman Spectroscopy. Food Control 2021, 121, 107652. https://doi.org/10.1016/j.foodcont.2020.107652


11. Armenian, P.; Vo, K. T.; Barr-Walker, J.; et al. Fentanyl, Fentanyl Analogs and Novel Synthetic Opioids: A Comprehensive Review. Neuropharmacology 2018, 134 (Pt A), 121–132. https://doi.org/10.1016/j.neuropharm.2017.10.016


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