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Pipetting Solutions Aid Allergy Prevention Research
Researchers at Uppsala University in Sweden are using Integra Biosciences’ PIPETBOY pro pipette controllers with integrated LED lighting to study the physiological function of mast cells and their role in allergic reactions. Their ultimate aim is to develop novel vaccines and therapies to prevent and treat common allergies.
The incidence of atopic allergies – such as hay fever and asthma – has dramatically increased in the past 50 years, with up to 30% of people in some western countries experiencing severe symptoms requiring medical intervention. Mast cells have been found to induce strong inflammatory reactions in response to immunoglobulin E, prompting a team at the university’s Department of Cell and Molecular Biology to research the part they play in triggering the allergic response.
Dr Srinivas Akula, Postdoctoral Researcher in the department, said: “We use PIPETBOY pro pipette controllers for purifying and culturing mast cells. They are vital tools for all of our multiple workflows. We have used PIPETBOYs for over a decade now, and we’re extremely happy with their performance and reliability. They continually dispense highly accurate volumes, which is very important for robust and reliable experiments.”
Srinivas concluded: “We would like to extend our portfolio of Integra products in the future with the EVOLVE multichannel manual pipettes and ECO Rack GripTip pipette tips. This would further speed up our workflow and increase our capacity for mast cell culture, taking us even closer to an effective treatment for the potentially debilitating allergies suffered by millions worldwide.”
More information online:
ilmt.co/PL/k1EO Mercury Analysis in Food Samples – A Case Study
Are you analysing for total mercury content and have a large number of samples to process? In a recent case study, Milestone spoke to Aquagro®
Aquagro® , a seafood exporter who invested in a Milestone DMA-80
mercury analyser in 2019. Due to rapid growth in the business they recently invested in a second instrument and now they analyse approximately 6,500 samples per month - over 200 samples a day.
say: “For our business at Aquagro, controlling mercury concentrations is critical. Milestone has proven
to be a reliable partner in our decision-making process, which highlights its commitment and professionalism to its customers. We are completely satisfied with the stability and reliability of the results with our two DMA-80 systems; we would certainly recommend this instrument and Milestone as a trusted partner.”
Mercury analysis can be a cumbersome process with multiple sample preparation steps required. Furthermore, instrumentation can require extensive and frequent calibration, as often as twice a day.
The Milestone DMA-80 Direct Mercury Analyser from Analytix overcomes these common problems as a calibration can last up to six months and is matrix independent. Samples require no sample preparation and are simply weighted into sample boats and loaded into the instrument. Measurements take as little as six minutes and total mercury results are generated at the end of analysis.
Given the ease of use and cost effectiveness, the system is also ideal for use out in the field or off-shore. Systems can be calibrated in the lab/on-shore prior to shipment, also meaning that hazardous mercury does not need to be shipped with the system. Maintenance is simple, with support often performed remotely, ideal when up-time is crucial.
Contact Analytix for a copy of the Aquagro case study. More information online:
ilmt.co/PL/X15k
Investment in Lyobeads – A Massive Step Forward for Lyo R&D
Biopharma Group has taken its extensive experience within the freeze-drying industry to help increase lyophilisation productivity, reduce costs and reduce cycle times by increasing lyobead production capabilities. Biopharma Group’s lyobead generation line can create millions of lyobeads a month.
‘Lyobeads’ (lyophilised spheres) are a huge step forward in the lyophilisation field and Biopharma Group has been at the forefront of its evolution. Lyobeads provide significant benefits in addition to those of conventional ‘lyocakes’. Lyobeads are more adaptable to product container changes, which can reduce time for R&D investment. They are suitable for high throughput, giving the possibility to load more into your dryer. From a quality product perspective, a larger surface area means reconstitution time is typically very good. Finally, storage and handling is simplified, since lyobeads can be stored in bulk prior to packaging, making storing and shipping far easier and safer for product viability.
Biopharma Group has invested heavily in lyobead technology and increased its production capabilities accordingly, which has proved to be of great value to R&D customers looking for fast delivery to market. With this move, millions of lyobeads can now be produced each month. Biopharma Group is proud to have designed and developed a ‘lyobeads generator’ which has the capacity to produce lyobeads based on the customer requirements.
Another benefit to of this investment is that, in addition to its R&D services, Biopharma Group can offer a complete end-to-end lyobead production line, consisting of: procurement and purchasing of reagents; preparation and compounding; generation of frozen beads; freeze drying; quality control; picking- and-Placing; packaging.
This increases productivity, reduces costs in the areas of transportation and storage, increases product stability and offers fast reconstitution.
In addition to processing and production, Biopharma Group’s in-house team of scientists can support the design and development of both bespoke formulations and lyo processes. The goal is to create robust lyobeads, easy to reconstitute, that would also preserve the reagent activity. Learn more about the contract R&D and manufacturing services Biopharma Group offers, or contact us with your requirements today. More information online:
ilmt.co/PL/7Nz0 and
ilmt.co/PL/jx4o
60454pr@reply-direct.com
59916pr@reply-direct.com
59949pr@reply-direct.com
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