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Ion Exchange HPLC Columns for Protein Charge Variant and AAV Separation Analysis
Thermo Fisher Scientific has introduced a new series of ion exchange columns that offer enhanced reproducibility, sensitivity, and durability to biopharmaceutical research labs. These columns are designed for charge-based analysis of therapeutic proteins and for separating full and empty adeno-associated virus (AAV) capsids utilised in gene therapy.
The ProPac 3R HPLC column portfolio from Thermo Scientific utilises advanced monodisperse particle technology to provide exceptional reproducibility and consistent outcomes over the lifecycle of a drug - from R&D to commercialisation. With a new 3 µm particle size, it offers superior separation capabilities, including ultra-high resolution of charge variants, faster run times, and improved peak resolution.
The collection includes robust strong anion-exchange (SAX) and strong cation-exchange (SCX) column chemistries, available in two column lengths (50mm and 100mm) and two inner diameters (2mm and 4mm).
The new line of ion exchange columns from Thermo Fisher Scientific is built to be compatible with the mobile phases and organic solvents utilised in biopharmaceutical applications. These columns are made from bio-inert materials to reduce secondary interactions. Furthermore, they offer an improved peak-to-valley resolution of charge variants to increase certainty when quantifying critical quality attributes. The columns also provide confidence in detecting and identifying new acidic or basic variants during late-stage development. They have a high sample-loading capacity and analytical flexibility that allows for excellent sensitivity and performance under a broad range of pH, temperature, and mobile phase compositions, as well as MS capabilities.
More information online:
ilmt.co/PL/OV3q 60114pr@reply-direct.com
Seamless Integration of Microplate Evaporators and Liquid Handling Robots Porvair Sciences’ Ultravap®
Mistral microplate evaporators are globally renowned for their ability to remove solvent
evaporation bottlenecks in laboratories worldwide, catering to 12- to 384-well microplates and glass vials of up to 15 cm height.
The new generation of Ultravap® Mistral evaporators have been updated with a flat front profile and platform shuttle
for seamless interfacing with liquid-handling robots, offering increased automation efficiency. Proprietary advances in gas injection technology ensure reproducible sample throughput by delivering heated gas directly and consistently to each well and tube. The Ultravap®
RS232 control over every parameter and easy integration with liquid handling robots for full automation of microplate dry-down.
Porvair’s latest addition to their evaporator line, the Ultravap® Mistral XT-150, offers significant throughput advantages
to laboratories handling frequent sample preparation tasks. With its advanced evaporator head technology and innovative manifold design, the XT-150 achieves faster sample throughput than centrifugal evaporation for single plates and tube racks. The evaporator’s heated nitrogen injection system, which delivers temperatures up to 80ºC directly to each well of the microplate simultaneously, further enhances its efficiency.
Porvair Sciences has developed the Ultravap® software allows multiple Ultravap®
Mistral core software that allows control of multiple operating units at once. This advanced Mistral evaporators to be connected in series using the latest CAN interface technology. This means that
a method selected on a primary unit will be automatically distributed over the CAN Bus to all downstream units, allowing the program to run simultaneously.
More information online:
ilmt.co/PL/z1jz and
ilmt.co/PL/p1kw 60264pr@reply-direct.com
Mistral’s open-access design, combined with powerful operating software, allows full
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