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Excitation Wavelength Selection with a Flick of the Thumb
With the most recent introduction of a new multi-wavelength excitation-laser coupling unit WITec has further advanced the ease-of-use of its microscope series. It is now possible to switch between up to three laser sources by the simple rotation of a filter wheel.
Calibration and alignment of the laser beam path is guaranteed at all positions assuring accurate and variable Raman Imaging. Each excitation wavelength features a high quality and wavelength optimised filter set, enabling the highest throughput and greatly contributes to the exceptional speed and sensitivity of WITec’s systems. Experiments specifically requiring a variety of lasers, for example, to eliminate fluorescence can benefit from such a multi-laser setup, making the alpha300 and alpha500 series even more versatile and applicable to a wide range of applications.
Circle no. 377
LABORATORY PRODUCTS
The Four Aces of Temperature Control
Ireland’s First Fragment- Based Screening Programme Thermo Fisher Scientific,
Inc recently announced that the University of Dublin has purchased the Maybridge Ro3 Diversity Fragment library for use in a new drug discovery program. As an institution known for its world-class biomedical research, the University is the first organisation in the Republic of Ireland to undertake a fragment-based screening programme. With possible applications in the fight against viral replication, bacterial infections and Alzheimer’s disease, this research has the potential to provide significant therapeutic advances.
Dr Neil Ferguson’s team – the UCD Biomolecular Interactions Group – combines state-of-the-art biophysical and structural biology methodologies to unravel the molecular structures and forces that cause human diseases. By incorporating the Maybridge Ro3 library into his existing multi-disciplinary approach, Dr Ferguson adds a new dimension to his team’s research and their ability to identify potential drug compounds. The Ro3 library will enable the team to pursue challenging targets, neglected diseases and, in many cases, new targets emerging from his basic research programmes.
Pre-register before 1 Nov 2011 Held in conjunction with :
“Combining the power of fragment-based drug discovery with our high-end instrumentation, we can effectively tackle our ever-expanding portfolio of therapeutic targets,” said Dr Ferguson. “Our aim is to identify novel leads that can develop into next-generation therapeutics. I gave long and serious consideration to the fragment library that we would use for this new initiative. Among the key criteria were the chemical diversity, validated solubility profiles and a proven track record in hit identification. The ready availability of its components in bulk format and their superior stability also makes the Maybridge Ro3 library an excellent choice for further development of the downstream medicinal chemistry.” Dr Ferguson concluded: “We feel that our current skill set, therapeutic targets, biophysical infrastructure and the Maybridge Ro3 library all place us well to make a serious fragment-based drug discovery effort within the academic sphere – watch this space!” The Maybridge Ro3 Diversity Fragment library is a resource of more than 1500, hand-selected, compound fragments and small molecule pharmacophores. This highly diverse fragment library is available as three 500-compound sets; each compound in the library is pre-solubilised as a 1mL, 10mM solution, providing 10 µMol of 95% purity material dissolved in analytical grade DMSO.
Circle no. 379 Organiser : Worldwide Associate :
Huber offer temperature control systems to match the demands of almost any application requirement. Ranging from the Unistat Hybrid, which can be intergrated into centralised systems for large volume reactors, to small chillers, immersion and circulation thermostarts for a range of applications. Despite their size, these units are real all-rounders, offering incredible power with small foot prints and environmentally friendly refrigeration - making them truly product aces.
The Petite Fleur, the baby tango is the smallest Unistat temperature control system. With a footprint of just 260 x 450 x 504 the petite fleur offers a temperature range of -120 to +200°C with cooling capacity of 480 Watts at 20°C. The Petite Fleur is ideal for the control of reactors and an externally open version is now available.
Huber Ministats are the smallest cooling thermostats in the world. Despite their size they have enough power to thermoregulate photometers, refractometers, viscosimeters, distillation apparatus, reactor vessels and mini plants. Their compact form allows them to be placed in areas where space is at a premium, for example laboratory extraction hoods. Ministats are available in three models with a temperature range from -45 to +200°C and cooling capacities of 600 watts. They can be used to control externally closed applications or alternatively objects can be thermoregulated directly within the bath.
The compact Minichiller is designed as a space saving tower and with a footprint of just 225 x 360mm it takes up less bench space than many laptops. With a temperature range of -20 to +40°C and cooling capacity of 300 watts at 15°C, Minichillers are ideal for cooling reaction blocks, vapour traps, vacuum pump condensers, rotary evaporators or heat exchangers, supplying predictable and correct pressure, flow and temperature to applications resulting in tangible process efficiencies. Because the Minichiller's internal volume is only 2 litres, it eliminates the risk of flooding in the laboratory. This allows the process to be run unattended further increasing efficiency.
The MPC range of low cost heating and cooling immersion circulators have now been improved, featuring a 4 digit temperature display with a resolution of 0.1°C. The mechanical over temperature setting has been replaced by a digital LED Display. In addition the option to select the temperature control mode (internal/process) has been added. All models are available as an ‘Advanced Version’ with an RS232 interface and external Pt100 sensor connection. MPC’s reach a stability of +-0.05°C, they are fitted with over temperature and low level protection, meeting safety class III/FL (DIN 12876).
Circle no. 380
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Circle no. 378 LAB ASIA - JULY/AUGUST - LABORATORY PRODUCTS
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