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CHROMATOGRAPHY
Case Study Documents Cost-Saving API Residual Analysis
Phenomenex, Inc announces the publication of a case study, written by scientists at Pfizer, that demonstrates the results of a new method for residual API (active pharmaceutical ingredient) analysis. This new solution replaces 16 older methods for individual key ingredients, and has delivered cost savings of £320,000 (more than $516,000) per year. The method requires just one UHPLC instrument, using Phenomenex Kinetex®
1.7-micron core-shell columns, to resolve all 16 ingredients in just six minutes. reduces waste disposal costs and frees up lab analysts.
“High-volume laboratories, such as those in pharmaceutical QC, have an acute need to reduce operating costs and free up resources,” explained Jeremy Bierman, Brand Manager for HPLC products. “The Kinetex core-shell technology allows the development of faster and more efficient analytical methods to deliver significant cost and time savings.”
The Kinetex 1.7-micron column is the first and only sub-2-micron core-shell UHPLC column on the market and typically delivers efficiency gains of 15 to 20% over traditional fully porous sub-2-micron columns. Circle no. 329 In addition to instrument and time-savings, the method uses less solvent,
Routine Quantitative LC-MS Software
Thermo Fisher Scientific, Inc introduced Thermo Scientific TraceFinder 1.1, its latest software for clinical research, forensic toxicology, food safety and environmental testing laboratories performing routine, high-throughput quantitation by LC-MS. The software retains all of the capabilities of its predecessor and has been expanded to include complete integration with the Thermo Scientific Transcend system.
It is also compatible with all Thermo Scientific quantitative mass spectrometry platforms, including the Thermo Scientific Exactive and LTQ family of systems. “Our customers asked for easy-to-use software for routine LC-MS quantitation that integrates seamlessly with their front- end system of choice - the Transcend System - and all of the Thermo Scientific quantitative LC-MS systems, including the LTQ series and the Exactive,” said Ian Jardine, Vice President of global R&D, Thermo Fisher Scientific.
“We enhanced TraceFinder 1.1 specifically to meet these needs, and now customers have one software solution for method development, data acquisition, data processing and report generation that they can use with our Thermo Scientific TSQ Series triple stage quadrupole system, the Exactive, Orbitrap or one of our ion trap systems. This will enable them to significantly improve laboratory productivity.”
The TraceFinder™ software is designed to make routine LC-MS quantitation and targeted analysis simple, fast and productive. The software offers a four-step, workflow-driven method setup and fully automated data acquisition, data processing and reporting. It includes an extensive choice of preconfigured methods and more than 50 report templates, as well as compound data stores for selected reaction monitoring (SRM) experiments in environmental testing, food safety residue analysis, clinical research and forensic toxicology applications. Data review is easy with the ability to specify and report multiple flags. To protect the integrity of analytical data, the software includes a rights-based secure user login system.
The Transcend™ system combines the power of automated online sample preparation and multiplexing to increase throughput without compromising data quality or sensitivity.
The unique multiplexing technology of the Transcend system brings the productivity of up to four separate, parallel LC systems to a single mass spectrometer, enabling clinical research, forensic toxicology, food testing and environmental laboratories to achieve a four-fold increase in sample throughput. Thermo Scientific TurboFlow Technology automates sample preparation and can reduce the time spent on this task by up to 95%.
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Highest Performing UPLC Ever Engineered
Waters Corporation introduced the new Waters®
ACQUITY UPLC® highest performing UPLC®
I-Class System, the system ever
engineered taking UltraPerformance LC® separations technology to the next level. For scientists challenged by the most difficult separations, the ACQUITY UPLC I-Class features the lowest system dispersion and lowest carryover in the industry today. Low dispersion maximises peak capacity thereby advancing chromatographic separations and optimising the performance of any mass spectrometer.
Keeping pace with today's most advanced laboratories, the ACQUITY UPLC I-Class System excels when analysing complex, sample-limited compounds. Sample-limited compounds include high potency medications, trace levels of food or water contamination, and (advanced) sophisticated biotherapeutics. These samples can represent complex separation challenges requiring an LC system that can maximise the benefits of sub-two-micron for faster throughput and optimised MS performance.
While there are many innovations built into the new ACQUITY UPLC I-Class, minimal system volume is a new key feature. Reduced system volume significantly decreases dispersion rates for reproducibly higher resolution and superior peak capacity. Reduced dispersion and small peak volumes extend the sensitivity of any mass spectrometer. Additionally, low dispersion footprint allows users to reduce their separation cycle times without impact to the separation as resolution is maintained even for ballistic gradients lasting less than one minute. Also importantly, new design and materials dramatically reduce sample carryover effects, thus increasing user confidence in results.
The ACQUITY UPLC I-Class also features class leading flexibility and precise sampling capabilities. Depending on application needs, users can choose either the highest precision and lowest dispersion fixed-loop Sample Manager, or the world's first low dispersion variable volume Sample Manager with a flow-through needle design, which delivers high-precision injections, excellent sample recovery, and lowest sample carryover optimising the performance for even the most sensitive mass detectors.
Circle no. 332
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Circle no. 331
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