11 New Method for EPO
Impurity Analysis Phenomenex, Inc announces the publication of a new method for the analysis of aggregates of EPO (Erythropoietin), a widely manufactured recombinant biosimilar protein therapeutic. As patent protection expires for the original EPO drugs, many companies are working to produce generic versions, resulting in a skyrocketing need for method development and validation.
The new gel filtration chromatography (GFC) method developed by Phenomenex quantifies aggregates in these recombinant therapeutics using a BioSep-SEC-s2000 series column, which provides a superior separation window for low-molecular-weight proteins.
“Our published data shows a clear advantage in using this BioSep column and our GFC method, over the columns used in the past,” explained Michael McGinley, HPLC Product Manager for Phenomenex. “This rugged yet simple method effectively analyses the amount of aggregate and dimer in these low- molecular-weight samples.”
A technical note on the new Phenomenex EPO method has just been published and can be accessed online.
Circle no. 326 iPad Application at HPLC
Waters Corporation unveiled a suite of capabilities within one Apple iPad application that ensures customers can quickly and easily choose the most appropriate Waters®
ACQUITY UPLC® sample plates, vials and filters in a matter of seconds.
“We are very excited to leverage the mobile communication technology that is becoming more important in today’s laboratory environment,” said Dr Mark Baynham, Director, Channel Canagement at Waters. “Many of our customers are extending the use of mobile devices into their professional lives, including laboratory management. For those customers, we have approached the development of our iPad app with the same level of understanding and commitment to innovation that Waters brings to all product development. The initial app has been designed specifically for the iPad platform and sets the stage for future innovative tools designed for lab scientists.”
Simply walk through the steps and each of the capabilities within this Waters application will make recommendations tailored to users needs, along with alternative options. Plate Selector - enter basic information on sample volume and sample quantity, and the selector will identify the best ACQUITY UPLC plate for the user application, along with alternative options. Vials Selector - the Waters vial selector offers vial options matching the criteria the user has entered, such as the system they are using, sample volume, detection method and light sensitivity of analytes.
Filter Selector - determine the most appropriate filter for individual analysis in three easy steps. By entering the particle size, sample volume and sample type into the filter selector, it will identify the most suitable filter.
Developed with an architecture that allows for future expansion and updates, without needing to install a new version of the app from the app store, Waters’ suite of iPad capabilities is designed to take advantage of the iPad functionality combined with Waters’ understanding of customers’ needs to enable customers to make effective decisions. Development of the app was a direct result of the technical collaboration between Waters and Roundarch, a leader in digital design and development for the world’s largest organisations.
Circle no. 325
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Circle no. 327
LAB ASIA - JULY/AUGUST - CHROMATOGRAPHY
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