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Cover Story JANUARY/FEBRUARY 2012 - VOLUME 37 ISSUE 1


If you are performing routine analyses or developing methods, or just prefer the flexibility of multi-solvent capabilities in a quaternary- based system, the only choice has been HPLC, until now.


ACQUITY UPLC H-CLASS SYSTEM Only one system can transfer methods seamlessly from HPLC to UPLC®


® . And it’s only from Waters. See the difference at waters.com/hclass


©2012 Waters Corporation. Waters, UPLC and ACQUITY UPLC are registered trademarks of Waters Corporation. The Science of What’s Possible is a trademark of Waters Corporation.


Circle no. 1


The ACQUITY UPLC H-Class delivers high resolution, sensitivity and improved throughput, while maintaining the robustness and reliability that ACQUITY systems are known for. Choosing the ACQUITY UPLC H-Class enables you to continue running existing HPLC methods on a forward-looking LC platform that allows you to confidently and seamlessly transition to UPLC separations, when you’re ready, using integrated system tools and reliable column kits for method transfer and method development that simplify migration.


Circle no. 1


In this Issue Chromatography


Chromatographic Characterisation and Purification Techniques for BioPharm Focusing on Monoclonal Antibody Derived Drugs


Dr.Chris Bevan


Automated Analysis of Canister Air and Gas – A Cryogen-free Solution


Dr Nicola Watson 6 Mass Spectrometry & Spectroscopy


Geoffrey Rule, Daniel Eikel, Jason Vega, Chris Alpha and Jack Henion


16-23


Automated Liquid Extraction Surface Analysis (LESA) from a Dried Blood Spot Card Holder via Chip-Based Nanoelectrospray


16 INTERNATIONAL LABMATE


Head Office - International Labmate Ltd Oak Court, Sandridge Park, St AIbans, Hertfordshire AL3 6PH, United Kingdom. Tel: +44 (0)1727 855574 • Fax: +44 (0)1727 841694 Email: info@intlabmate.com • sales@intlabmate.com ISSN 0143-5140


Total Average Net Circulation 30,723


Oct–Dec 2010


Publishers of: International Labmate, Labmate UK & Ireland, Lab Asia, Chromatography Today, International Environmental Technology, Asian Environmental Technology, Pollution Solutions, Petro Industry News and Measurement Analysis China


35 Years in the International Market Tamsyn Cox


Publisher Michael H. Pattison


Director of Publications Marcus Pattison


michael@intlabmate.com marcus@intlabmate.com


North American Area Manager Carol Hardy


Director, Asia Pacific Marie Izzard


carol@intlabmate.com mizzard@optusnet.com.au


Sales & Marketing Manager Chris Jarvis


Area Managers John Hobbs-Morris Carly Hider


Classified Sales Silvi Sutherland


Online Manager Rob Parker


Online Account Manager Jay Domoney


Guide Manager Sam Jackson


Guide Assistant Joanna Hemmings


Reader Services Manager Sue Petts


chris@intlabmate.com


john@intlabmate.com carly@intlabmate.com


silvi@intlabmate.com rob@intlabmate.com jay@intlabmate.com sam@intlabmate.com joanna@intlabmate.com sue@intlabmate.com Editor Gwyneth Astles


Features Editor Tamsyn Cox


Contributing Editor Heather Hobbs


gwyneth@intlabmate.com tamsyn@intlabmate.com heather@intlabmate.com


Contributing Editor - Separation Science Bernie Monaghan


bernie@intlabmate.com


Print Production & Procurement Manager Gary Durham


Production Manager Robert Battell


Production Team Heather Vincent Jill Mitchell Caroline Belt


Finance Controller Chris Brown


Accounts Manager Jacky Page


Accounts Assistants Nikki Kaloczi


Maureen Woodhouse


Credit Control Patricia Rogers


Market Research Printed by Warners Midlands Plc, Covers printed by Colt Press Ltd, Published by International Labmate Ltd


Published: January, February, April, May Buyers Guide, July, August, October International Labmate is distributed to scientists, technologists, laboratory technicians and environmentalists throughout the Europe and Middle East, free of charge. The publication has the support of leading suppliers of equipment in the region and is displayed at the major exhibitions and conferences in these markets to attract additional readership.


Subscriptions: FOR ONE YEAR; Outside Europe or the Middle East - $100. Cheques made payable to International Labmate Ltd Alternatively fill in the Buying Now/User card and tick the subscription box


In order to obtain information on any of the products included in this journal, please fill in the appropriate numbers on the Reader Reply card and post or fax it to us. Alternatively contact the company directly by email, phone or via the website.


Buying Now Scientific Instruments Survey: Should you use or be planning to buy scientific apparatus and would like to receive the latest available information, please return the appropriate card.


North American Office: Carol Hardy - International Labmate Ltd 6635 West Happy Valley Road, Suite 104, #505, Glendale, AZ 85310, United States Tel: +(1) 623-869-0184 Fax: +(1) 623-321-9200 E-mail: carol@intlabmate.com


Asian Office: Marie Izzard - International Labmate Ltd Peninsula Business Centre, Ground Floor, Suite 1, 20 Bungan Street, Mona Vale, NSW, 2103, Australia Tel: +61 (0)2 9979-6886 Fax: +61 (0)2 9979-9181 E-mail: mizzard@optusnet.com.au


Japan: Mr Koichi Ogawa - OTO Research Corporation Takeuchi Building 1 -34-12 Takatanobaba, Shinjuku-Ku, Tokyo 169, Japan Tel: (03) 3208 7821 Fax: (03) 3200 2889


Korea: Dong-Shik Chai, Dong-Myung Communications Inc 191-1. Pyungchang-Dong, Chongno-Ku , Seoul, 110-012 Korea Tel: 82 2 391 4254 Fax: 82 2 391 4255


Microscopy News Heather Hobbs


82 Special Features


Sample Preparation & Processing Tamsyn Cox


28


International Labmate is published six times per annum in tabloid format. In addition a most comprehensive "Guide to Laboratory and Environmental Equipment" printed in A4 format. It incorporates companies, products and dealers, mailed in May/June.


Although every effort is made to ensure the accuracy of material published, International Labmate and its offices cannot accept responsibility for claims made by contributors, manufacturers or advertisers.


© All rights reserved by International Labmate Ltd. Reproduction in part or whole without written permission is strictly prohibited. Please look after the environment by recycling this magazine


Pumps Valves & Liquid Handling Tamsyn Cox


We wish to apologise for an error in the October edition of International Labmate in which Dr Hélène Javot, a scientific researcher in the Laboratory of Developmental Plant Biology at the Institute of Environmental Biology and Biotechnology (IBEB, France), was incorrectly cited as an employee of Olympus Europa Holding GmbH (page 64). Dr Javot has no commercial affiliations with the company.


66


Food & Beverage Analysis Tamsyn Cox


50 80 gary@intlabmate.com robert@intlabmate.com


heatherv@intlabmate.com jill@intlabmate.com


caroline@intlabmate.com chris@labmate.net jacky@labmate.net


nikkik@labmate.net maureen@labmate.net


patricia@labmate.net Marstonbury Ltd


Microscopy & Microtechnology


Thermal Imaging Cameras Confirm Effectiveness of Local Anaesthetics


Loic Premartin European Microscopy Congress 2012 78 78-84


Business Opportunities Asia Heather Hobbs


74 SHOW PREVIEWS


PITTCON - Page 36 ARABLAB - Page 56


Industry Viewpoint Heather Hobbs


48 36 26


News & Views Heather Hobbs


24 Laboratory Products


Research & Events News Heather Hobbs


2 2-88 4


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COVER STORY


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