Mass Spectrometry & Spectroscopy 23 New Series of Stand-Alone and PC Controlled Spectrophotometers
GE Healthcare’s new Ultrospec™ series of dual beam, UV-visible spectrophotometers provides research scientists with a choice of smart instruments with diverse capabilities to deliver reproducible results, precision and ease of use to match a variety of user requirements. The series includes Ultrospec 7000/7000PC for day-to-day laboratory activities, Ultrospec 8000/8000PC, and the top of the range 9000/9000PC system for demanding assays. Each version is available as either a stand-alone or PC controlled system.
The Ultrospec range benefits from the following features: dual beam instrument (with a variety of bandwidths); Ultrospec 7000/7000PC offers a 2nm bandwidth; Ultrospec 8000/8000PC offers a 1nm bandwidth; Ultrospec 9000/9000PC offers variable bandwidth optics – for difficult samples; colour touchscreen (for stand-alone product); USB data and PC connectivity; European Pharmacopoeia research compatibility (8000/9000 models); Datrys Standard (option to upgrade to Datrys Life Science or Datrys CFR); Equation Editor software – enabling custom calculations on measured data; and an extended range of accessories available such as thermostatting, Bluetooth™ and Datrys software option.
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Co-Market Agreement Aims to Advance Glycobiology by Dramatically Speeding Glycan Characterisation Thermo Fisher Scientific, Inc and PREMIER Biosoft, recently announced an agreement to co-market PREMIER Biosoft’s SimGlycan®
software. The
agreement aims to advance glycobiology by dramatically speeding the characterisation of complex glycans through automated interpretation of the rich data produced by Thermo Scientific mass spectrometer systems. Glycans - oligosaccharide or polysaccharide molecules found attached to proteins and lipids in virtually all multicellular organisms - serve essential roles in biological processes as diverse as protein folding, immune function, and energy storage. Because glycans have the potential to serve as markers for disease, and because changes to glycans in a biologically based drug can affect the drug’s function, bioinformatics tools that simplify and expedite structural elucidation of glycans are of intense interest to the scientific community and the pharmaceutical industry.
Due to the sensitivity of mass spectrometers and their ability to analyse complex glycan mixtures, mass spectrometry has emerged as a powerful tool for glycan structural elucidation. However, MS-based approaches generate large volumes of data that, until the introduction of SimGlycan software, required hours or days of tedious manual interpretation. SimGlycan software automatically matches experimentally acquired mass spectra against a comprehensive database and generates a list of candidate glycan structures scored to reflect match quality. Additional, relevant biological information about the proposed glycan structure such as glycan class and biological pathway are made immediately available via interactive links. Unlike other software, SimGlycan can process the multi-stage/sequential mass spectrometry (MSn) data produced by Thermo Scientific mass spectrometers. This unique capability aids in discriminating between glycans that have similar fragment ions at the MS/MS level, and resolves their carbohydrate distribution and branching patterns. Up to six or seven levels of fragmentation are typically needed to differentiate between glycan structural isomers. SimGlycan software is designed for use with Thermo Scientific Orbitrap and ion trap mass spectrometers, including the Thermo Scientific LTQ, LTQ Velos and Velos Pro linear ion trap systems and the LTQ Orbitrap XL, Orbitrap Velos, Orbitrap Velos Pro, Orbitrap Elite and MALDI Orbitrap hybrid systems.
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High-Sensitivity Spectrometer Ideal for Low Light Level, UV-Sensitive Applications
Ocean Optics has added triggering functions to its Maya2000 Pro back-thinned CCD miniature spectrometer to provide accurate timing and synchronisation between the spectrometer and other devices. Three low-jitter trigger and normal operating modes are now possible. Applications include pulsing a light source to occur when acquiring a spectra and synchronising spectral acquisition to coordinate with samples moving through a process stream or sensors reaching a certain temperature level.
In addition to triggering, Ocean Optics has enhanced Maya2000 Pro performance with support for RS-232 communications and improved optoelectronics that increase dynamic range (to 15000:1), lower trigger jitter (to 100 ns) and decrease dark noise (to 6 RMS counts).
Triggering provides precise timing between devices. The Maya2000 Pro can be triggered so that sending the spectrometer a pulse causes it to do something such as turn off or on a light, activate a pulse in a pulsed light source or start or end spectral acquisition in the spectrometer.
For example, in the External Triggering mode, an event outside the sampling system (such as a button push, lever activation or laser) electronically pulses the spectrometer’s trigger pin and starts acquisition of the spectra with microsecond accuracy.
The Maya2000 Pro has a 30-pin connector and 10 user-programmable digital I/Os. Its enhanced onboard programmable high-speed FPGA controller enables triggering and provides other performance advantages.
Available operating modes are Normal (spectrometer continuously acquires spectra) and the three trigger modes: External Hardware Level Trigger; External Synchronous Trigger; and External Hardware Edge Trigger.
The Maya2000 Pro is a back-thinned 2D FFT-CCD spectrometer with high sensitivity, 75% peak quantum efficiency and excellent UV response. Maya2000 Series spectrometers are ideal for low light-level applications such as fluorescence, DNA sequencing and measurement of certain biological samples. The spectrometer can be used in the VUV (to ~150 nm) with the addition of a nitrogen purgebox to help lessen the absorption of water and oxygen in the VU.
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My SPECORD® Time for new demands!
Double-beam spectrophotometer SPECORD® The premium allrounder for all applications
Comprehensive method collection Intuitive multilingual software navigation Modular software concept No warm-up phase, plug and play Extensive range of accessories
Visit us at analytica 2012, Munich/Germany 17-20/04/2012 in hall A1, booth 211/310
PLUS
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INTERNATIONAL LABMATE - JANUARY/FEBRUARY 2012
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