table 1. Mycobactericidal Effects of Aldehyde-Based Products Against GTA-Susceptible and GTA-Resistant Mycobacterium Isolates in Suspension Testsa
Product Tested
Mmas CIP108297 (GTAS)
Cidex (1.5% GTA), 25°C 0 min 5 min
8.20
10 min 15 min 30 min 0 min
45 min
5.27±0.08 0 0 0
nd nd
Aldahol (1.8% GTA), 20°C 0 min 5 min
10 min 15 min 30 min
7.25 0 0 0 0
Aldahol (1.8% GTA), 25°C 0 min 5 min
10 min 15 min 30 min
7.25 0 0 0 0
15% Isopropanol, 25°C 0 min 5 min
8.31 8.36±0.07
10 min 8.53±0.15 15 min 8.43±0.03 30 min 8.32±0.05
Cidex OPA (0.3% OPA), 25°C 0 min 5 min
10 min 15 min 30 min
12 min 30 min
7.25 0 0 0 0
Cidex OPA (0.3% OPA), 20°C 0 min
nd nd nd
Mmas CRM-0270 (GTAS)
8.29 0 0 0 0
nd nd
8.29 0 0 0 0
8.29 0 0 0 0
nd nd nd nd nd
8.29 0 0 0 0
5.13 0 0
Mmas CRM-0019 (GTAR)
7.79
7.47±0.04 7.48±0.13 7.48±0.05 7.23±0.03 7.39
6.76±0.02 6.69
4.54±0.13 3.36±0.01 2.49±0.71 0
6.69 0 0 0 0
8.23
9.02±0.03 8.86±0.08 8.87±0.00 8.88±0.10
7.32 0 0 0 0
7.64 0 0
Mch ATCC 35752 (GTAS)
7.11 0 0 0 0
nd nd
7.11 0 0 0 0
7.11 0 0 0 0
nd nd nd nd nd
7.11 0 0 0 0
7.69 0 0
Mch 9917 (GTAR)
7.06 7.49
Mch Harefield (GTAR)
7.60
Mch Epping (GTAR)
7.65
7.55±0.05 7.96±0.00 8.02±0.11 7.87±0.06 7.95±0.02
6.95±0.21 7.70±0.05 7.91±0.04 7.23±0.03 7.50±0.09 7.73±0.04 8.83
8.33 7.60 8.38
5.63±0.38 6.85±0.15 7.20±0.01 7.06
7.65
7.39±0.09 7.78±0.00 7.45±0.04 7.64±0.01 7.15±0.17 7.44±0.08 6.97±0.04 7.17±0.03 6.65±0.00
7.27 6.97 6.13
8.13 0 0 0 0
nd nd nd nd nd
8.13 0 0 0 0
8.27 0 0
7.60
7.30±0.02 4.70±00 0 6.92±0.25 6.58±0.17 5.98±0.17
7.65 0
0 0
nd nd nd nd nd
7.63
3.92±0.21 0 0 0
7.65 0 0
nd nd nd nd nd
7.65 0 0 0 0
7.80 0 0
6.29 0
0 0
nd nd nd nd nd
6.29 0 0 0 0
nd nd nd
NOTE. GTA, glutaraldehyde; OPA, ortho-phthalaldehyde; CFU, colony-forming units; GTAR, GTA-resistant; GTAS, GTA-susceptible. nd,
not determined. aThe mean log10 CFU counts and standard deviations of duplicate tests for each strain and test product are shown. The 0-minute time point (enumeration of CFU in the bacterial suspension prior to disinfectant exposure) is the result of a single serial dilution plating. Control suspension tests using the GTA-susceptible isolate, M. massiliense CIP 108297, confirmed the neutralizing efficacy of the neutralizing broth with each disinfectant product. The detection limit of the suspension tests is 1 CFU/mL.
M. bovis BCG (Pasteur) (GTAS)
6.29
4.33±0.26 3.30±2.55 0 0
nd nd
6.29 0 0 0 0
M. avium 104 (GTAS)
8.04 nd
5.97±0.03 5.10±0.35 0
nd nd
8.16 0 0 0 0
8.32 0
0 0
nd nd nd nd nd
8.32 0 0 0 0
nd nd nd
M. terrae ATCC 15755 (GTAS)
7.97
4.70±0.18 3.81±0.14 3.18±0.21 0
nd nd
7.97 0 0 0 0
7.97 0 0 0 0
nd nd nd nd nd
7.97 0 0 0 0
nd nd nd
disinfectant susceptibility of mycobacteria 787
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