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PROMOTION


PROFHILO®: A ‘NEW HA’ FOR BIOREMODELING SKIN LAXITY


Prof. Chiara Schiraldi describes the new patented technology and its advantages, while Dr. Annalisa Beatini shares a new technique, the protocol and results of the first multicenter evaluation behind this innovative new product PROFHILO®


PROFESSOR CHIARA SCHIRALDI, Second University of Naples, BIOTEKNET - Biotechnology, Medical Histology and Molecular Biology Contact: chiara.schiraldi@ unina2.it


P


DR ANNALISA BEATINI, currently practices Aesthetic Medicine, Dermatologic Surgery and Laser Therapy in Liguria, Italy


Contact: annalisabeatini@ libero.it


ROFHILO® IS THE NEW product presented by IBSA, a pharmaceutical company and leader in the production of hyaluronic acid (HA),


owing to its complete control of the entire HA life cycle from the production of the raw material to the finished product. IBSA, through its extensive scientific knowledge regarding HA, has developed a new patented technology of stabilized hybrid complexes, making available a concentration of 64mg of hyaluronic acid in one pre-filled syringe. Hyaluronic acid is a molecule that has been studied and used for a long time, the characteristics and benefits of which are universally recognized. So, what can be added to everything that is already known about this formidable substance?


PROFHILO®: technology and innovation with complete safety In particular, the production of unique,


stable


2ml), while maintaining complete manageability, has been unimaginable until now in this new product called PROFHILO®. PROFHILO® generates a new method of intervention which, through a single infiltration solution, allows the levels of endogenous HA to be integrated with equal concentrations of high and low weight HA hybrids. The combined action of the


hybrids associates the regenerating trophic effect of the L-HA on the epidermis (HYDRO effect), and the plastic modeling effect of the dermis (LIFT effect) carried out by the H-HA; Hydrolift® Action. The PROFHILO® technology, in addition to supporting Hydrolift® Action by integrating the levels of endogenous hyaluronic acid, is able to optimize the Hydrolift® Action thanks to the presence of the stabilized hybrid complexes. In fact, PROFHILO® offers: ■A prolonged action1


: PROFHILO® molecular hybrids


proven feasible through a specific procedure involving a thermal treatment. Thanks to this new patented technology, the combination


32mg of high 80 ❚


molecular weight HA between 1100– 1400kDa (H-HA) and 32mg of low molecular weight HA between 80– 100 kDa (L-HA) has been made possible. Concentrations of hyaluronan in one syringe (64mg in


March 2015 | prime-journal.com


hybrid complex has been proven to protect the high molecular weight HA (>1000kDa) present in the complex, reducing the degradation by eight times that of H-HA alone


■A high concentration of hyaluronic acid (32mg/1ml) with maximum manageability1


viscosity obtained in PROFHILO®, with respect to HA alone, permits the use of a 29G needle with a superior homogeneous spreading in the dermis


: The lower dynamic ■Reduced inflammation1 : The low


molecular weight is slowly released from the hybrid network and therefore, the first inflammatory cytokines (TGF-β) are not upregulated, lowering the overall inflammatory cascade, or limiting the first ‘inflammation’ phase to a positive light shock to ‘sleeping/tired’ cells. Highly biocompatible: PROFHILO®


is in fact, a highly purified natural hyaluronic acid which does not contain chemicals (cross-linking agents) to modify the structure, therefore reducing the risk of adverse reactions.


Bioremodeling Thanks to its unique characteristics, PROFHILO® provides a new tool to combat facial skin ageing: bioremodeling, or the ability to act on skin laxity. Bioremodeling differs from


traditional biorejuvenation for three main reasons: ■Reduced number of injection points


■The time necessary for each treatment session


■Immediate results sustained longer over time.


The BAP (Bio Aesthetic Points) technique The BAP technique was studied in IBSA’s laboratories and was further developed by a team of trusted physicians and surgeons, resources essential to understand the overall


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