PEER-REVIEW | HAIR RESTORATION |
Figure 15 Density and diameter variation at 12 months regarding sex
50 40 30 20 10 0
-10 -20
F cases over 12 months post-treatment with PRP. They
observed an improvement of 19.7% for the density variation at 3 months that reached 38% at 12 months. The aspect of the curve suggests that new follicles were not being produced, and the authors believe that PRP treatment stimulates many live follicles that are not strong enough to provide hair. Therefore, ‘new’ hair is observed, but not new follicles.
The goal was to get the best result for the patient and the authors are
evaluating other studies with different protocols and will soon be able to quantify the result and improve the protocol.
Globally, concerning the diameter, no significant
changes, except for advancing age (60–80 years) and women in stage 3, were observed. It would be useful to consolidate these results with
other evaluations of the same type, provided by other teams and gradually define the best protocols for the best results.
Declaration of interest None Figures 1-17 © Gilbert Amgar and Pierre Bouhanna
Figure 14 (A) Before and (B) 12 months after two PRP sessions
Key points This article intended to
retrospectively evaluate a cohort of 70 patients with progressive androgenic alopecia
These patients
underwent a combination therapy with injection of platelet extracts (without any activation) and a rotary single-use multipuncture instrument. Digital measurements (tattoo mark, hair density, calibre, and ratio) and standard photographs were taken from each participant
An improvement of
19.7% for the density variation at 3 months, reaching 38% at 12 months was observed
Concerning the caliber, no significant changes, except for advancing age (60–80 years) and women in stage 3 were observed
References
1. Rosenthal A, Harbury C, Egbert P, Rubenstein E. Use of a platelet- fibrinogen-thrombin mixture as a corneal adhesive: experiments with sutureless lamellar keratoplasty in the rabbit. Invest Ophthalmol 1975;14(11): 872-5
2. Bouhanna P. Different methods of evaluation--object assessment of hair loss and alopecia. Praxis, 1997; 86(23): 1000-1003
3. Hoffmann R, Happle R. Current understanding of androgenetic alopecia. Part II: clinical aspects and treatment. Eur J Dermatol 2000; 10(5): 410–7
4. Takakura N, Yoshida H, Kunisada T, Nishikawa S, Nishikawa S.. Involvement of Platelet Derived Growth Factor Receptor-alpha in Hair Canal Formation. J Invest Dermatol 1996 ; 107(5): 770-777
34 ❚
5. Yano K, Brown L, Detmar M. Control of hair growth and follicle size by VEGF-mediated angiogenesis. J Clin Invest 2001, 107(4): 409-417
6. Rinaldi F, Sorbellini E, Bezzola P. The role of up-stimulation of growth factors in hair transplantation: improve the revascularization of transplanted hair growth mediated by angiogenesis. Forum 2007; 2
7. Sharov A, Tobin DJ, Sharova TJ, et al. Changes in different melanocyte populations during hair follicle involution. J Invest Dermatol, 2005; 125: 1259-1267
8. Li M, Marubayashi A, Nakaya Y, et al. Minoxidil-induced hair growth is mediated by adenosine in cultured dermal papilla cells: possible involvement
of sulfonylurea receptor 2B as a target of Minoxidil. J Invest Dermatol 2001; 117(6): 1594-1600
9. Mak KK, Chan SY. Epidermal growth factor as a biologie switch in hair growth cycle. J Biol Chem 2003; 278(28): 26120-6
10. Rosenquist TA, Martin GR. Fibroblast growth factor signalling in the hair growth cycle: expression of the fibroblast-growth factor receptor and ligand genes in the murine hair follicle. Dev Din 1996; 205(4): 379-386
11. Weger N, Schlake T. IGF-I signalling controls the hair growth cycle and the differentiation of hair shafts. J Invest Dermatol 2005; 125(5): 873-882
12. Mak KK. A transgenic mouse model to study the role of epidermal growth factor (EGF) in hair and skin
development. University of Hong Kong, 2002. Available at:
http://dx.doi. org/10.5353/th_b4257678 [last accessed February 4 2015]
13. Peters EMJ, Paus R, Klapp BF, Arck PC. L6 neuroimmunological hair growth control is stress-sensitive: an old paradigm revisited. Conference abstracts. Zurich: European Hair Research Society, 2005. Available at:
http://www.ehrs.org/ conferenceabstracts/2005zurich/ guestlectures/
L6-peters.htm [last accessed February 4 2015]
14. Sorbellini E, Trink A, Rinaldi F. Experimental clinical assessment of the use of platelet-rich plasma in dermatology and rationale for its use in the treatment of non-scarring alopecia. La Medicina Estetica 2011; 35 (4)
15. Takikawa M, Nakamura S, Nakamura S, et al. Enhanced Effect of Platelet-Rich Plasma Containing a New Carrier on Hair Growth. Dermatol Surg 2011; 37(12): 1721-9
16. J Greco, R Brandt. The effects of autologus platelet rich plasma and various growth factors on non- transplanted miniaturized hair. Hair Transplant Forum International 2009; 19(2): 49-50
17. Sciavone G, Raskovic D, Greco J, Abeni D. Platelet-Rich Plasma for androgenic alopecia: a pilot study. Dermatol Surg 2014; 40(9): 1010-9
18. Li ZJ1, Choi HI, Choi DK. Autologus platelet rich plasma: A potential Therapeutic Tool for Promoting Hair Growth. Dermatol Surg 2012; 38(7 Pt 1): 1040-6
Density var Caliber var
44.53 3.43
M
31.37 -7.57
Figure 16 Density and diameter variation at 12 months regarding age
80 60 40 20 0
-20 20–39
Density var Caliber var
25.05 -8.19
40–59 32.91 0.17
60–80 74.39 5.42
Figure 17 Density and diameter variation at 12 months regarding stage for women
140 120 100 80 60 40 20 0
-20 -40
Density var Caliber var
1
15.35 -14.49
2
28.78 -1.43
3
129.39 36.30
Mean 44.53
3.43
Mean 37.95
-2.07
March 2015 |
prime-journal.com
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