volumetric result, but also biologically stimulate the CD44 receptors of mesenchymal stem cells, boosting the adipogenesis, so new adipose tissues are produced. Tests confirm that adipose tissues increase by 10–15%. There are several formulations of
Biorivolumetria products, which depend on the type of correction required, the degree of de- structuring and the areas to be treated. Regenyal Idea Bio- Expander, very soft and elastic, is especially
suitable for the
superficial hypoderm and is recommended for areas such as cheeks, forehead, barcode, temporal, and perioral areas. Injected into the most superficial part
of the dermal connection,
hypoderm, this
at . the product
interacts with the CD44 receptors of the fibroblasts improving the reticular dermis and the skin14,15 Regenyal Super Idea and
Regenyal Idea are ideal for injections into deeper layers, where a more significant volumetric action is necessary: cheekbones, nasolabial fold, and mouth angles.
Effects created by the treatments
Sometimes it is useful to combine deep-action products with the ones injectable into superficial layers, like in the clinical case in Figure 2. Here you can see that the volume in the malar area was restored at deeper levels with Super Idea, while treatments at the superficial hypodermal layer in the malar area were performed with Bio-Expander. As shown in the post-treatment not
picture, only is the volume
restored in a natural way, but the skin itself appears improved. In fact both, the patient and the physician,
notice a natural volumization and improvement in the skin texture, elasticity and firmness. The skin improves progressively
with each treatment; the patient will not return to their initial conditions. The chart (Figure 3) clearly shows the concept of Biorivolumetria. While going down, the curve that indicates the volumetric action crosses the curve representing the regeneration: as the volume decreases, there is an increase in the regenerative effect. This means that even after the product is absorbed, there is still a volume related to the regenerative effect.
Conclusion All this is a big step ahead in the evolution of aesthetic medicine, that leaves behind the important but simple experience of the so called ‘Filler’, where a long-lasting correction was often the target with the risk of compromising the aesthetic result. Biorivolumetria creates natural while
results preventing and
treating skin ageing; this has been observed in thousands of patients treated.
References
1. Montagna W, Carlisle K. Structural changes in ageing skin. Br. J. Dermatol 1990; 122: 61
2. Meyer LJ, Stern R. Age-dependent changes of hyaluronan in human skin. J. Invest. Dermatol 1994; 102: 358
3. Alessandrini A. Face Anatomy. Ed: ItaliaMedica & Acta Medica, 2015
4. Alessandrini A. Destrutturazioni ipovolumetriche del viso (ID). L’ambulatorio medico 2012; 35: 17-19
5. Alessandrini A. Biorivolumetria: la quarta dimensione in medicina estetica, L’ambulatorio medico 2012; 36: 9-11
6. Alessandrini A. Bio-rivolumetria. Dossier Medicina focus 2012; 16: 14-15
7. Presti D, Scott JE. Hyaluronan-mediated protective effect against cell damage caused by enzymatically produced hydroxyl (OH )
radicals is dependent on hyaluronan molecular mass. Cell Biochem. Funct 1994; 12: 281
8. Fraser JRE, Laurent TC, Laurent UBG. Hyaluronan: Its nature, distribution, functions and turnover. J. Intern. Med 1997; 242: 27
9. Tammi R, Agren U, Tuhkanen M, Tammi M. Hyaluronan metabolism in skin. Prog. Histochem. Cytochem 1994; 29: 1
10. Zuk PA, Zhu M, Ashjian P, De Ugarte DA, Huang JI, Mizuno H, Alfonso ZC, Fraser JK, Benhaim P, Hedrick MH. Human Adipose Tissue is a Source of Multipotent Stem Cells. Molecular Biology of the Cell 2002; 13: 4279-4295
11. Lesley J, Hascall VC, Tammi M, Hyman R. Hyaluronan Binding by Cell Surface. The Journal of Biological Chemistry 2000; CD44,
275(35): 26967-26975
12. Flynn L, Prestwich GD, Semple JL, Woodhouse KA. Adipose tissue engineering with naturally derived scaffolds and adipose-derived stem cells. Biomaterials. 2007; 28(26): 3834-42
13. Von Heimburg D, Zachariah S, Low A, Pallua N. Influence of Different Biodegradable Carriers on the in Vivo Behavior of Human Adipose Precursor Cells
14. Doillon CJ, Wassermann AJ, Berg RA, Silver FH. Behaviour of fibroblasts and epidermal cells cultivated on analogues of extracellular matrix. Biomaterials 1988; 9: 91
15. Yoneda M, Yamagata M, Suzuki S, Kimata K. Hyaluronic acid modulates proliferation of mouse dermal fibroblasts in culture. J. Cell Sci 1988; 90: 265
prime-journal.com | March 2015 ❚
Figure 2 Restoration of volume in the malar area and cheeks. (A) Before treatment, and (B) after treatment
100% 90% 80% 70% 60% 50% 40% 30% 20% 10% 0%
VOLUME REGENERATION
0 1
2
3
4
5
6 Month
Figure 3 Biorivolumetria effect over time. When the volume decreases the regeneration of tissues grows
7
8
9 10
11
12
79
Biorivolumetria effect %
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