This page contains a Flash digital edition of a book.
| COMBINATIONAL AESTHETIC APPROACHES | PEER-REVIEW


convincing results. Thread lifting and injection lipolysis also represent promising minimally invasive procedures, although additional study data and optimisation of protocols and material/agents may be needed before giving final recommendations. Particularly with the latter procedures, recommendations on potential useful combinations and chronical orders are mostly based on individual indications, personal experience, patient desires, and costs. The author tends to begin with BoNTA procedures relatively early and — after a certain age — combines these with non- or ablative fractional procedures (depending on quality of the skin surface) for skin tightening and further improvement of fine wrinkles. After improvements of skin texture, the author administers filling materials (depending on skin quality, preference of patients; however, HA is most frequently used) and usually starts restoring the malar contour first, followed by the orbital-malar groove and — if needed — nasolabial and marionette folds. In cases of excess fatty tissue or significant skin laxity in the lower face, injection lipolysis or thread lifting may be employed if patients do not want surgical procedures.


Conclusion Improved understanding of the complex anatomic alterations of the ageing face has shifted the focus from treating individual wrinkles to a rather holistic paradigm. A combination of the here described options tailored to the individual needs of patients will help create natural- appearing results and, therefore, a high level of patient satisfaction. With all the options available to date, a detailed facial


analysis and documentation is necessary. In depth discussion of available alternatives, their indications, safety aspects, costs, and duration of results prior to any therapy are warranted to maximize patient satisfaction and minimize side-effect profile. In depth understanding of the complex anatomy of the human face is mandatory


Key points Anti-ageing treatment


to date frequently asks for a multidimensional approach in order to target the complex age-related alterations in facial skin, musculature, fatty tissues, and bone


A combination of


different approaches may optimize and maximize aesthetic outcomes and patient satisfaction


With all the options


available to date, a detailed facial analysis and in depth discussion of available alternatives, their indications, as well as safety aspects is necessary


Solid knowledge of


anatomy, techniques, materials, and associated indications are crucial


A ‘less is more’


approach and scheduled touch-up sessions may prevent most adverse events and will help maximize patient satisfaction


not only for treatment with fillers and BoNTA but also for other approaches such as thread lifting and injection lipolysis. Only careful patient selection and counselling will lead to expected outcomes and will prevent side-effects such as skin dimpling, temporary numbness, and extruded or visible cones such as those observed after thread lifting. These complications depend more on technique and less on products. While combination of the herein described options tailored to the individual needs of the patient will often lead to more natural- appearing results it should not be underestimated that some combinations may increase the risk of additional unpredictable side-effects. Potential interaction between certain filling materials


or lasers, which have not yet been studied in detail, should lead to careful handling. Even though signed informed consent of the patient may protect the responsible clinician legally, side–effects, even transient and mild ones, represent time lost from work and will decrease patient trust if not clearly communicated beforehand. From the author’s experience, solid knowledge of


anatomy, techniques, materials, and associated indications are crucial. Furthermore, careful explanation of side effects and expected outcomes prior to the procedure, as well as a ‘less is more’ approach and scheduled touch-up sessions will prevent most adverse events and will help maximize patient satisfaction.


Declaration of interest None Figures 1–5 © Gerd G. Gauglitz


cutaneous remodeling using microscopic patterns of thermal injury. Lasers Surg Med 2004; 34: 426-438


32. Laubach HJ, Tannous Z, Anderson RR, Manstein D. Skin responses to fractional photothermolysis. Lasers Surg Med 2006; 38: 142-149


33. Krueger N, Sadick NS. New-generation radiofrequency technology. Cutis 2013; 91: 39-46


34. Lolis MS, Goldberg DJ. Radiofrequency in cosmetic dermatology: a review. Dermatologic surgery : official publication for American Society for Dermatologic Surgery 2012; 38: 1765-1776


35. Atiyeh BS, Dibo SA. Nonsurgical nonablative treatment of aging skin: radiofrequency technologies between aggressive marketing and evidence- based efficacy. Aesthetic plastic surgery 2009; 33: 283-294


36. Zelickson BD, Kist D, Bernstein E, et al. Histological and ultrastructural evaluation of the effects of a radiofrequency-based nonablative dermal remodeling device: a pilot study. Archives of dermatology 2004; 140: 204-209


37. Kennedy JE, Ter Haar GR, Cranston D. High intensity focused ultrasound: surgery of the future? The British journal of radiology 2003; 76: 590-599


38. Gliklich RE, White WM, Slayton MH, Barthe PG, Makin IR. Clinical pilot study of intense ultrasound therapy to deep dermal facial skin and subcutaneous tissues. Archives of facial plastic surgery 2007; 9: 88-95


39. Alam M, White LE, Martin N, Witherspoon J, Yoo S, West DP. Ultrasound tightening of facial and neck skin: a rater-blinded prospective cohort study. Journal of the American Academy of Dermatology 2010; 62: 262-269


40. Suh DH, Oh YJ, Lee SJ, et al. A intense-focused ultrasound tightening for the treatment of infraorbital laxity. Journal of cosmetic and laser therapy: official publication of the European Society for Laser Dermatology 2012; 14: 290-295


41. Chan NP, Shek SY, Yu CS, Ho SG, Yeung CK, Chan HH. Safety study of transcutaneous focused ultrasound for non-invasive skin tightening in Asians. Lasers in surgery and medicine 2011; 43: 366-375


42. Garg S, Baveja S. Combination therapy in the management of atrophic acne scars. Journal of cutaneous and aesthetic surgery 2014; 7: 18-23


43. Aust MC, Fernandes D, Kolokythas P, Kaplan HM, Vogt PM. Percutaneous collagen induction therapy: an alternative


treatment for scars, wrinkles, and skin laxity. Plastic and reconstructive surgery 2008; 121: 1421-1429


44. Khunger N. Standard guidelines of care for chemical peels. Indian journal of dermatology, venereology and leprology 2008; 74 Suppl:S5-12


45. Nguyen T. Dermatology procedures: microdermabrasion and chemical peels. FP essentials 2014; 426: 16-23


46. Park TH, Seo SW, Whang KW. Facial rejuvenation with fine-barbed threads: the simple Miz lift. Aesthetic plastic surgery 2014; 38: 69-74


47. Garvey PB, Ricciardelli EJ, Gampper T. Outcomes in threadlift for facial rejuvenation. Annals of plastic surgery 2009; 62: 482-485


48. Abraham RF, DeFatta RJ, Williams EF, 3rd. Thread-lift for facial rejuvenation: assessment of long-term results. Archives of facial plastic surgery 2009; 11: 178-183


49. Atiyeh BS, Dibo SA, Costagliola M, Hayek SN. Barbed sutures ‘lunch time’ lifting: evidence-based efficacy. Journal of cosmetic dermatology 2010; 9: 132-141


50. Schuller-Petrovic S, Wolkart G, Hofler G, Neuhold N, Freisinger F, Brunner F. Tissue-toxic effects of phosphatidylcholine/deoxycholate after subcutaneous injection for fat dissolution in rats and a human volunteer.


Dermatologic surgery 2008; 34: 529-542; discussion 542-523


51. Rotunda AM, Suzuki H, Moy RL, Kolodney MS. Detergent effects of sodium deoxycholate are a major feature of an injectable phosphatidylcholine formulation used for localized fat dissolution. Dermatologic surgery: official publication for American Society for Dermatologic Surgery 2004; 30: 1001-1008


52. Bechara FG, Mannherz HG, Jacob M, et al. Induction of fat cell necrosis in human fat tissue after treatment with phosphatidylcholine and deoxycholate. Journal of the European Academy of Dermatology and Venereology: JEADV 2012; 26: 180-185


53. Salti G, Rauso R. Comments on ‘Injection lipolysis with phosphatidylcholine and deoxycholate’. Aesthetic surgery journal / the American Society for Aesthetic Plastic surgery 2014; 34: 639-640


54. Duncan DI, Hasengschwandtner F. Lipodissolve for subcutaneous fat reduction and skin retraction. Aesthetic surgery journal / the American Society for Aesthetic Plastic surgery 2005; 25: 530-543


55. Tanner B, Barabas T, Crook D, Link C. A future for injection lipolysis? Aesthetic


prime-journal.com | March 2015 ❚


surgery journal / the American Society for Aesthetic Plastic surgery 2013; 33: 456-457


56. Rzany B, Griffiths T, Walker P, Lippert S, McDiarmid J, Havlickova B. Reduction of unwanted submental fat with ATX-101 (deoxycholic acid), an adipocytolytic injectable treatment: results from a phase III, randomized, placebo-controlled study. The British journal of dermatology 2014; 170: 445-453


57. Ascher B, Hoffmann K, Walker P, Lippert S, Wollina U, Havlickova B. Efficacy, patient-reported outcomes and safety profile of ATX-101 (deoxycholic acid), an injectable drug for the reduction of unwanted submental fat: results from a phase III, randomized, placebo-controlled study. Journal of the European Academy of Dermatology and Venereology: JEADV. 2014; 28: 1707-1715


58. McDiarmid J, Ruiz JB, Lee D, Lippert S, Hartisch C, Havlickova B. Results from a pooled analysis of two European, randomized, placebo-controlled, phase 3 studies of ATX-101 for the pharmacologic reduction of excess submental fat. Aesthetic plastic surgery 2014; 38: 849-860


53


Page 1  |  Page 2  |  Page 3  |  Page 4  |  Page 5  |  Page 6  |  Page 7  |  Page 8  |  Page 9  |  Page 10  |  Page 11  |  Page 12  |  Page 13  |  Page 14  |  Page 15  |  Page 16  |  Page 17  |  Page 18  |  Page 19  |  Page 20  |  Page 21  |  Page 22  |  Page 23  |  Page 24  |  Page 25  |  Page 26  |  Page 27  |  Page 28  |  Page 29  |  Page 30  |  Page 31  |  Page 32  |  Page 33  |  Page 34  |  Page 35  |  Page 36  |  Page 37  |  Page 38  |  Page 39  |  Page 40  |  Page 41  |  Page 42  |  Page 43  |  Page 44  |  Page 45  |  Page 46  |  Page 47  |  Page 48  |  Page 49  |  Page 50  |  Page 51  |  Page 52  |  Page 53  |  Page 54  |  Page 55  |  Page 56  |  Page 57  |  Page 58  |  Page 59  |  Page 60  |  Page 61  |  Page 62  |  Page 63  |  Page 64  |  Page 65  |  Page 66  |  Page 67  |  Page 68  |  Page 69  |  Page 70  |  Page 71  |  Page 72  |  Page 73  |  Page 74  |  Page 75  |  Page 76  |  Page 77  |  Page 78  |  Page 79  |  Page 80  |  Page 81  |  Page 82  |  Page 83  |  Page 84  |  Page 85  |  Page 86  |  Page 87  |  Page 88  |  Page 89  |  Page 90  |  Page 91  |  Page 92  |  Page 93  |  Page 94  |  Page 95  |  Page 96