PEER-REVIEW | COSMECEUTICALS |
Table 7 Overview of clinical studies with erythema-reducing agents
Polypodium leucotomos
Polypodium leucotomos
Polypodium leucotomos
2% Sage extract
10% Witch hazel
Carotenoid mix
mix
Resveratrol, green tea,
21 10 9
+ Photo- – Photo-
damage damage
Oral/
– Erythema Oral decrease
topical Oral
24 hour Significant
4 months Significant 24 hour
40 + Erythema Topical 48 hour decrease
36 + Erythema Oral decrease
48% Lycopene 36 – Erythema Oral decrease
16 caffeine mix – Facial redness
12 weeks 12 weeks
Topical 12 weeks
Significant Significant
40 + Erythema Topical 24-72 hour Significant decrease
Significant Significant Significant
reduction
photoisomerization of transurocanic acid, a common photoreceptor located in the stratum corneum50
witch hazel, carotenoids, lycopene, and grape seed extracts have also shown protection against erythema50
.
Discussion Laboratory and clinical data suggest that the use of
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of erythema . Sage,
78/LOE-II 79/LOE-III 80/LOE-III 81/LOE-I 82/LOE-I 83/LOE-I 84/LOE-II 85/LOE-III
cosmeceuticals is a very promising field, and their potential applications in various disease and aesthetic conditions is bountiful. However, review of the current scientific literature pertaining to peptide, growth factor, stem cells, antioxidant and pigment/ erythema reducing agents as having anti-ageing and rejuvenation effects produced a limited number of evidence
low-level studies.
Furthermore, since the majority of studies were conducted by
the
manufacturer of each cosmeceutical, the evident conflict of interest raises questions regarding the objective design and interpretation of the results. Cosmeceutical products
claim to affect the structure and function of skin, thus they are beholden to higher standards of scientific substantiation than cosmetic products. These standards should include at minimum being able to substantiate the three major questions proposed by Dr. Albert Kligman: a clear understanding that the ingredient penetrates into skin, a defined mechanism of action, and that it has specific clinical effects with continued topical use.
Therapies targeting optimal rejuvenation should be invariably geared toward addressing the intrinsic and
March 2015 |
prime-journal.com
Erythema- reducing agents
Patients
Placebo controlled Study
endpoints
Route of administration Treatment
Results/ improvement
Reference/ level of evidence
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