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| DERMAL REJUVENATION | ARTICLE Key points ■ CO2 therapy, thanks to


the properties of this gas, can be considered one of the most effective and most studied treatments for the imperfections of the lower limbs


■ It is better to infiltrate


small amounts of CO2 along specific vectors rather than large amount of gas


Figure 6 Detachment lines for stretch marks treatment


areas. This is achieved through the vasodilation induced by CO2


therapy, as well as changes in blood flow


and vasomotion, which have been demonstrated by capillaroscopy, Doppler, and laser Doppler flow 6,7,8,12


. Furthermore, it has been shown that CO2 therapy


increased oxygenation of peripheral tissues, owing to the artificial Bohr effect and the lipolytic action on adipose tissue, without damaging the connective tissue or reducing the adipose tissue thickness 8–10,16,17


. Figure 1 shows landmarks used to divide the different


gluteal, trochanteric, and thigh regions. It is not necessary to infiltrate large volumes of CO2


to each area; rather,


small amounts in the direction of the vectors shown in Figure 2 can be used. Furthermore, it is important to treat with small intradermal CO2


points on the great saphenous vein path. Figure 4 and Figure 5 show the reduction of the thighÕs circumference and skin quality in a young patient at the end of a complete treatment.


Treatment of stretch marks Stretch marks (striae atrophic, atrophy dermoÐ epidermal striae) are injuries caused by the shredding of the dermis and epidermis. They appear like linear scars and their origin are related to breakage of the collagen fibres, which occurs when the tissue is not sufficiently elastic, and to ischaemic damage owing to distension of the dermal capillaries. Their occurrence is likely related to both mechanic (i.e.


weight loss) and hormonal factors (i.e. steroid therapy), while the existence of a genetic predisposition is not clearly demonstrated. The positive effects of CO2


therapy on the blood flow


and oxygenation of peripheral tissue contributes to reduce the hypoxic damage, which is related to the aetiology of stretch marks. Histological examinations performed after treatment with CO2


showed that it


modified, treatment by treatment, the structure of the dermis, inducing an increase in thickness and a more widespread distribution of collagen fibres 8


. Figure 6 shows the insufflation technique and Figure 7


shows the result obtained. The technique provides small infiltrations along the course of the stretch mark as shown in Figure 6, at the end of eight treatment sessions an improvement of skin quality can be noted (Figure 7).


infiltrations along some key


Figure 7 Stretch marks in a 44-year-old patient (A). Results after eight treatments (B)


Conclusions Data in the literature makes it possible to conclude that CO2


of vascular diseases and skin affections.  Declaration of interest None declared  Figure images Matteo Campana


■ It is mandatory to use safe and certified device for CO2


administration


therapy is a safe and useful treatment for a number


References


1. Vacher. Ulceration croniques de membres inferieurs:interet des jets alternes de gaz thermale de Royat e d’oxygene-rev de medicine Clermont Ferrand 5–1987.


2. Charrier. La cure de Royat et sa Place dans le traitement de l’arterite de membres inferieurs-revue de med. de Tours 1975


3. Re A. La cura termale delle malattie dei cuori e dei vasi. Minerva Medica 1964


4. Varlaro V, Parassoni L, Bartoletti CA. La carbossiterapia nella pefs e nell’adiposita’localizzata. Riv. La Medicina Estetica, Anno 19 numero 1 Gennaio/marzo, Roma: 1995. Editrice Salus Internazionale.


5. Savin E, Bailliart O, Bonnin P et al. Vasomotor effects of transcutaneous CO2 stage II periphearal occlusive arterial disease. Angiology 1995; 46: 785


6. Hartmann BR, Bassenge E, Hartmann M. Effects of serialpercutaneous application of carbon dioxide in intermittentclaudication: Results of a controlled trial. Angiology


1997; 48: 957


7. Hartmann BR, Bassenge E, Pittler M. Effect of carbondioxide- enriched water and fresh water on the cutaneous microcirculation and oxygen tension in the skin of the foot. Angiology 1997; 48: 337


8. Brandi C, D’Aniello C, Grimaldi L et al. Carbon dioxide therapy in the treatment of localized adiposities: clinical study and histopathological correlations. Aesthetic Plast Surg, 2001; 25 (3): 170–4


9. Brandi C, D’Aniello C, Grimaldi L, Caiazzo E, Stanghellini E. Carbon dioxide therapy: effects on skin irregularity and its use as a complement to liposuction. Aesthetic Plast Surg 2004; 28 (4): 222–5


10. Lee GS. Carbon dioxide therapy in the treatment of cellulite: an audit of clinical practice. Aesthet Plast Surg 2010; 34 (2): 239–43


11. D’Aniello C, Brandi C, Lattarulo P, Bosi B, Grimaldi L. Il ruolo della carbossiterapia nella strategia terapeutica della Lipomatosi multipla simmetrica Rivista italiana di chirurgia plastica 1999; 31: 265–69


12. Brandi C, Grimaldi L, Nisi G et al. The role of carbon dioxide therapy in the treatment of chronic wounds. In Vivo 2010; 24 (2): 223–6


13. Jaltel. Royat, station termale de l’arterite- Imprimerie nouvelle Royat: les acrosyndromes 1995- Ed societe’ medicale de Royat


14. Campana M, Vaccaro M et al. Il ruolo della carbossiterapia nel trattamento sintomatico delle acrosindromi vascolari. Riv Ita Chir Plast 2009; 41 (3–4): 165–70


15. Balik O, Yilmaz M, Bagriyanik A. Does carbon dioxide therapy really diminish localized adiposities? Experimental study with rats. Aesthetic Plast Surg 2011; 35 (4): 470–4. Epub 2010 Dec 30


16. Brandi C, Campana M, Russo F et al. Carbon dioxide: maybe not the only one but an efficient and secure gas for treating local adiposities. Aesthetic Plast Surg 2012; 36 (1): 218–9


17. Sakai Y, Miwa M, Oe K, Ueha T, Koh A et al. A Novel System for Transcutaneous Application of Carbon Dioxide Causing an ‘Artificial Bohr Effect’ in the Human Body. PLoS ONE 2009; 6 (9): e24137


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