inducing second degree Wallerian degeneration of the axon. Within 24 hours, the axon regenerates down the endoneurial fascicle, which is unaffected by cold, along the original path of the nerve at 1–2 mm per day towards the motor endplates. Muscle contraction will resume over time as the nerve assumes normal function. Research carried out to date has indicated that the overall appearance of dynamic forehead lines are reduced for up to 16 weeks following treatment. Pre-clinical studies examined the
safety and effectiveness of both single and multiple iovera° treatments on the motor nerves in rat hindlimb model. All treatment groups showed a weakening of hind limb function followed by normal recovery, which demonstrated that the treated nerve underwent axonal degeneration followed by normal regeneration and re-innervation of the target muscle groups. The weakening and recovery of hindlimb function were consistent after each successive treatment and long-term observations have shown that normal function is assumed. This highlights that there is no cumulative change to the function of the treated nerve tissue. Histological analysis also confirms the recovery of normal tissue structures following both single and multiple applications of low temperatures to the motor nerves to reduce physiological function. iovera° treatment uses electrical
stimulation to accurately identify the targeted nerves. The precision-controlled treatment also includes integral dermis protection, which minimises damage to the surrounding tissue. The iovera° system is compact, making it easy and convenient for physicians to use,
while its contemporary, stylish and high-tech appearance engages patient interest.
The results Over 125 subjects have taken part in a series of clinical trials to test the effectiveness and safety of iovera° in the treatment of dynamic forehead wrinkles. Patients were assessed using the 5-point Wrinkle Scale (5WS) and the Global Improvement Scale (GIS), and the results showed that the appearance of forehead wrinkles was temporarily, yet effectively, reduced following iovera° treatment. The most common side-effects experienced were tenderness, redness, bruising and swelling at the needle insertion site. Dr Kai-Uwe Schlaudraff, Plastic
Surgeon at the Concept Clinic in Geneva, comments: ‘iovera° is a great addition to the range of wrinkle treatments that I can offer to my patients, especially those seeking instant,
results — without the use of neurotoxins;
natural looking it is the biggest
innovation in aesthetic treatments in years.’
myoscience support for you myoscience
provides
comprehensive and ongoing training and support, which begins with access to the iovera° inner circle. This is a centralised, interactive online portal for you to find the latest information about iovera°, communicate with the iovera° team and share experience with other physicians. You can also download marketing materials and complete online training modules. Additional expert physician-led training and field representative support
prime-journal.com | March 2013
will ensure you have the skills and confidence to make iovera° an integral part of your practice. Eye-catching and impactful patient
information and marketing materials are designed to help you promote iovera° in your clinic and drive patient demand.
Social
media and traditional press campaigns will also support you in raising consumer awareness about iovera° and generate ongoing interest.
E Further information
www.iovera.com
E Myoscience will also be hosting a symposium and live demonstration at the AMWC on Saturday 6 April 12.00–13.00, Room Ravel
E AMWC stand number N3
❚
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