38 SCALP CARE


Figure 1: Coffee, coffee cherry and cascara. The coffee cherry consists of an inner bean and an outer shell, known as cascara. During coffee processing, the bean is separated for coffee production, while cascara remains as a byproduct. As a phytochemically rich plant material with cosmetic potential, cascara represents an attractive upcycled botanical resource


Cascara Caffeine Extract Cascara Extract + Caffeine


vs.


Cascara Caffeine Extract has superior content of... Green Coffee Extract


Caffeine


150 100 50 0


100 100


150 100 50 0


Cascara Caffeine Extract


Green Coffee


Roasted Coffee


Cascara Pure Caffeine Polyphenols


150 100 50 0


100 109 89 80


150 100 50 0


Cascara Caffeine Extract


Green Coffee


Roasted Coffee


Cascara Pure Caffeine Antioxidative Power


150 100 50 0


100 111 88 95 100 89 100 100 75 50


Cascara Caffeine Extract


Green Coffee


Roasted Coffee


Tannis 150


98 Cascara Pure Caffeine Roasted Coffee Extract Cascara Extract Pure Caffeine Through caffeine enrichment, it also delivers


enhanced stimulating activity associated with scalp vitality. Compared with pure caffeine, the cascara caffeine extract offers a broader phytochemical profile and additional protective botanical constituents. Compared with conventional coffee-based


Trigonelline


extracts, it provides more stimulating activity through its enriched caffeine content. In this way, the cascara caffeine extract combines the phytochemical richness of cascara with the well-established activity of caffeine, resulting in a higher-performance concept for scalp and hair care (Figure 3).


A protective shield for hair follicle cells The objective of this study was to determine whether the cascara caffeine extract can protect primary human hair follicle cells from intracellular free radicals and thereby support follicle longevity. To assess this, an in vitro LUCS (Light-Up Cell System) assay was performed.13


This live-


Cascara Caffeine Extract


Green Coffee


Roasted Coffee


Cascara Pure Caffeine Flavonoids


1. Cascara Caffeine Extract 2. Green Coffee Extract 3. Roasted Coffee Extract 4. Cascara Extract 5. Pure Caffeine


Cascara Caffeine Extract


Green Coffee


Roasted Coffee


Cascara Pure Caffeine


cell method measures intracellular free radical formation in cultured primary hair follicle cells by means of a light-activated, photo-responsive biosensor, allowing antioxidant effects to be quantified by fluorescence. Primary human hair follicle dermal papilla


cells (HFDPC) from Caucasian female donors were cultivated and exposed to serial dilutions of the cascara caffeine extract. After preincubation for one hour, the cells were subjected to light- induced oxidative stress, and intracellular free radical formation was monitored over repeated LED excitation cycles. The cascara caffeine extract showed


Figure 2: Comparative phytochemical profile of the cascara caffeine extract, pure caffeine and coffee- based botanical extracts. Reference extracts were prepared in propanediol/water and extracted for 48 hours. A caffeine reference solution was prepared at 1.5% in propanediol/water. Caffeine and trigonelline were quantified by HPLC, total polyphenols by the Folin-Ciocalteu assay, tannins by FeCl3 colorimetry, flavonoids by HPTLC and antioxidant activity by the DPPH radical-scavenging assay


PERSONAL CARE MAGAZINE June 2026


strong antioxidant protection, even at low concentrations. The calculated effective concentrations demonstrated that the extract reduced intracellular free radicals by 90% at 1% and by 50% at 0.37% (Figure 4). These findings indicate that the cascara


caffeine extract effectively protects hair follicle cells against oxidative stress, a key factor in follicle aging and senescence. By significantly reducing intracellular free radicals, the extract may help


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Concentration (%)


Concentration (%)


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