FUNCTIONAL INGREDIENTS
yeast that produces a >95% pure glycolipid that is easily recovered from the fermentation. With manufacturing flexibility in mind, we intentionally developed our processes for efficient technology transfer and scale up. Where possible, we simplified unit operations
and opted for readily available equipment and well-proven manufacturing technologies. Robust but straightforward process conditions are employed and easily maintained, keeping product quality as our key focal point. This approach provides optionality and flexibility in manufacturing and reduces costs. Our technology has easily transferred
to manufacturing, with simple downstream processing, allowing us to manufacture in any geography as sugar feedstock is available everywhere. Our goal is to manufacture as close to our customers as possible, reducing our carbon footprint and improving overall sustainability. Fortunately, both sugar and sugar-waste are available anywhere, enabling global production. In line with our commitment to sustainability,
we have integrated the principles of Green Chemistry into our process design. For example, the feedstock for fermentation is renewable sugar. In fact, a wide range of sugars from various sources may be used, including sugar derived from waste streams. Throughout the process we have kept energy
consumption low by avoiding extreme processing conditions. We have also worked to find alternatives and limit the use of solvents in our derivatization processes for the functionalized ingredients. After manufacturing, our spent biomass can
easily be repurposed in other industries and our process has shown great ability to recycle and reuse water. These approaches not only align with our company’s values of offering environmentally responsible products, but they also contribute to cost control and supply chain security, enabling broad market potential.
Conclusion Ruby Bio is focused on continuing our efforts to provide the world with high-performance bio- based, bio-derived surfactants, free from palm and toxic contaminants. We have launched two high-performing surfactants, with many more on the horizon. The yeast naturally creates molecules up and
1% FRAGRANCE IN WATER 5
4.5 4
3.5 3
2.5 2
1.5 1
0.5 0
Rosemary 4 3 2.5 2 1.5 1 1 1.7 1 1.75 1 2.4 2.5 2.5 4.25 4.5 CMC COMPARISON WITH OTHER SURFACTANTS
45 40 35 30 25 20 15 10 5 0
SPAN APG Sophorolipid NOVEL 30 RubyGL-EM1
Figure 7: CMC comparison of surfactants showing RubyGL-EM1’s superior performance when paired with SLS as compared to other surfactants
down the HLB scale, so our job is to harness these molecules and offer them as useful building blocks for consumer products. We want to see the world shift to natural and nature-based ingredients, and our platform was designed to support this change. In the face of elevated levels of geopolitical
chatter, consumers need to know their choices are doing good and less harm. At the same time, consumers deserve the best performance, sustainably. Consumers are demanding transparency so they can understand when they are making good choices. The desire for increased transparency and
awareness of ingredient origins drives complexity only when an ingredient is complex. Bio-based and bio-derived ingredients offer consumers a simple understanding of a formulation’s composition and origins, reducing this complexity and improving consumer confidence. In our case, this origin is just sugar, and therefore transparency is easy to offer. This simplicity of sustainability around
biobased ingredients can help demystify the complexity that has been created for consumers around issues like 1,4-dioxane, feedstock origins, and calculating sustainability measures. Leveraging a sugar-only feedstock has benefits
beyond easy tracing. Ruby’s yeast variant is agnostic to sugar source, which unlocks a future for sugar-waste as a feedstock. This upcycling potential for waste-sugar drives our surfactants - the building blocks of any formulation - toward a circular economy and the next generation of bio-surfactants.
Rhamnolipid ■ PEG-40 Hydrogenated Castor Oil ■ Ethoxylate (Tween 80) ■ RubyGL-SF1 ■
References 1. ICI Americas Inc. The HLB System: A Timesaving Guide to Emulsifier Selection. 1992; page 1-4. Publisher: ICI Americas Inc., Wilmington, DE
2. Ritchie H. Palm Oil. https://ourworldindata. org/palm-oil. ‘Palm oil - Production (tonnes)’. Data source: Food and Agriculture Organization of the United Nations (2023)
3. Ritchie H, Rosado P. ‘Data Page: Rapeseed production’, part of: ‘Agricultural Production’. Data adapted from Food and Agriculture Organization of the United Nations (2023).
https://ourworldindata.org/grapher/rapeseed- production
4. Ritchie H. Palm Oil. https://ourworldindata. org/palm-oil. ‘Oil of sesame seed - Production (Tonnes)’ [dataset]. Data source: Food and Agriculture Organization of the United Nations (2023).
5. Ritchie H. Palm Oil. https://ourworldindata. org/palm-oil. ‘Coconut oil’ [dataset]. Data source: Food and Agriculture Organization of the United Nations (2023).
6. Ritchie H. Palm Oil. https://ourworldindata. org/palm-oil. ‘Coconut oil’ [dataset]. Data source: Food and Agriculture Organization of the United Nations (2023).
7. Agency for Toxic Substance Registry. Public Health Statement for 1,4 Dioxane. 2015.
https://wwwn.cdc.gov/TSP/PHS/PHS. aspx?phsid=953&toxid=199
PC
8. New York State, Department of Environmental Conservation. 1,4-Dioxane Limits For Household Cleansing, Personal Care, And Cosmetic Products. 2020. https://dec.
ny.gov/environmental-protection/help-for- businesses/household-personal-cosmetic- dioxane-limits
9.
California.gov. 1,4-Dioxane. 2024. https://
www.p65warnings.ca.gov/fact-sheets/14- dioxane
10. European Chemical Agency. Registry of restriction intentions until outcome. 2024.
https://echa.europa.eu/registry-of-restriction- intentions
Red Rose + Grapefruit Garden Fresh Bamboo mint
Figure 8: Fragrance oil solubilization in water by various surfactants, normalized to RubyGL-SF1’s performance, to demonstrate superior performance as a fragrance solubilizer compared to other known solubilizers
www.personalcaremagazine.com
11. Stearn C. New law regarding 1,4-dioxane levels confusing for cosmetics and personal care product manufacturers. Cosmetics Design USA. 20 February 2023. https://www.
cosmeticsdesign.com/Article/2023/02/20/ aci-responds-to-ny-law-limiting-solvent-in- personal-care-products
July 2024 PERSONAL CARE
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Relative solubilizer loading
Relative CMCmix
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