New Imaging Technique Holds Light for Osteoporosis Therapies


A research team from the College of Medicine at the University of Saskatchewan has developed a new approach to imaging that could help to improve outcomes for osteoporosis sufferers, said to number more than 2.3 million people in Canada. The technique, which detects changes in bone tissue far more quickly than the bone densitometry scans currently used in health care, could lead to improved drug treatment for the condition.


Using the BMIT beamline of the Canadian Light Source at the University of Saskatchewan, Dr. David Cooper and colleagues were able to see the incredibly tiny pores inside cortical bone, the dense outer surface of bone that accounts for the majority of bone mass. These pores change over time, showing how bone tissue is continuously removed and replaced.


The researchers stimulated this bone turnover using parathyroid hormone, then tracked the changes in the pores of the cortical bone in as little as 14 days.


“In humans, the pores we were looking at are about the width of a few hairs – a quarter of a millimetre – and in rabbits they’re about


half that size,” said Cooper, whose latest breakthrough builds on a decade’s worth of work in this area. “Using micro-computed tomography (micro-CT) we were, for the fi rst time, able to see the shapes of these pores and actually track them over time.”


Study lead Dr. Kim Harrison said this research would not have been possible using conventional X-ray techniques. “This uses refractive qualities between soft and hard tissues which highlights these pores within the bone and makes it easier to image and track the changes,” she said.


“This really is the establishment of a fundamentally new way of looking at bone turnover,” said Cooper. “Nobody has ever been able to do this before in terms of tracking the pores.”


Current osteoporosis diagnostic testing, done by bone density scans, is “a very blunt instrument,” Cooper added. “It might take years for changes to be detectable. We’re detecting these things over weeks in animals. It could have a rapid impact on how current drugs used in the treatment of osteoporosis are deployed.”


More information online: ilmt.co/PL/p13B


Dr David Cooper (Credit: Canadian Light Source)


Dr Kim Harrison (Credit: Canadian Light Source) 59624pr@reply-direct.com


mmc2023 Bounces Back


Microscopy in Microbial Imaging and Public Health: 4th July, Manchester


As one of the biggest events of its kind in Europe the Microscience Microscopy Congress (mmc2023) incorporating EMAG 2023, celebrates its return this year, bringing the very best in microscopy, imaging and cytometry from across the globe.


With six parallel conference sessions, a world-class exhibition, workshops, satellite meetings, an international Imaging Competition and more, it’s simply the place to be for anyone who uses a microscope for work, study or pleasure.


Back at the superb Manchester Central conference centre for the fi rst time since 2019, the event will be taking place fully in person, providing the perfect opportunity for the scientifi c community to come together, make connections and share their research.


As always, many of the leading companies in microscopy and imaging will be on hand to demonstrate the very latest equipment and technology at the exhibition.


With oral presentation submissions approaching the Feb 9 cut-off date, entries for the popular RMS scientifi c imaging competition will be open until May 2, while the deadline for new and emerging concepts in microscopy poster abstracts is May 5.


More information online: ilmt.co/PL/0VLn 59621pr@reply-direct.com


The RMS has partnered with Microbiology Society to offer its members the opportunity to attend the sessions on Microbial Imaging & Public Health at the mmc2023 conference.


The cross-society meeting will help promote further interdisciplinary links by bringing a wide audience of imaging scientists and microbiologists together


collaboration across the fi elds.


Microbiology Society delegates are invited to register and attend the scheduled sessions on ‘Public Health: The Impact of Microscopy’ and ‘Microbial Imaging’ on Tuesday 4th July 2023 at Manchester Central, 09:00-18:30.


These sessions have been organised as part of the mmc2023 programme and will feature invited and accepted abstracts from those working at the interface of microbiology and the measurement & imaging sciences.


The RMS looks forward to welcoming microbiology colleagues by providing access to the trade show and exhibition, attendance at the morning plenary talk, attendance specifi cally for the Public Health and Microbial Imaging sessions and the evening poster sessions on the 4th July 2023.


More information online: ilmt.co/PL/1aOE 59622pr@reply-direct.com


to promote knowledge exchange and


Botanical Microscopy Meeting 2023, 2-6th April, Norwich UK


The 12th Botanical Microscopy Meeting, being held on 2-6 April at the John Innes Centre, Norwich, is the latest in a long running series of RMS sponsored meetings, dating back to the 1960s, encompassing all aspects of bioimaging relating to modern plant cell biology. Topics covered will include a mix of state-of-the art microscopy combined with the latest developments in plant cell biology, including morphogenesis, plant membranes, organelle dynamics, plant-microbe interactions as well as quantitative imaging and image analysis.


Keynote Speaker: Enrico Coen, John Innes Centre Invited Speakers include: Keith Duncan, The Donald Danforth Plant Science Cente, Mark Fricker, University of Oxford Laila Moubayidin, John Innes Centre Marisa Otegui, Center for Quantitative Cell Imaging Thomas Ott, University of Freiburg Nick Talbot, The Sainsbury Laboratory Dolf Weijers, Wageningen University


More information online: ilmt.co/PL/56kP 59618pr@reply-direct.com


Groundbreaking Microscope Claims Win at R&D 100 Awards Ceremony


WITec Co-founder and Managing Director Dr. Joachim Koenen was presented with a 2022 R&D 100 Award as a winner in the analytical/ test category for the company’s cryoRaman very low temperature molecular imaging system, during a gala dinner recently held in Coronado, California,


Created in cooperation with technology partner attocube systems AG, this instrument was said to be one of the year’s most innovative commercial product introductions, with potential to benefi t leading areas of research including investigations of phase transitions and novel 2D materials.


“We’re very proud of cryoRaman, it’s an innovation in the truest sense. The capability it provides to the researcher simply didn’t exist before,” said Dr. Koenen. “We’re very grateful to our development team for their hard work, our partners at attocube for their exceptional cooperation


and to R&D World for this great distinction.”


cryoRaman integrates a Raman microscope with a cryogenic sample chamber to enable high-resolution chemical characterisation extremely low temperatures and in strong magnetic fi elds.


at


The R&D 100 Awards, organised by R&D World magazine is a program that celebrates new devices and materials for their technological signifi cance. A panel of expert judges reviews submissions from across the industry and the Analytical/Test category recognises laboratory advancements specifi cally.


More information online: ilmt.co/PL/x1Ln 59625pr@reply-direct.com


WITec Managing Director Dr. Joachim Koenen at the 2022 R&D 100 Awards ceremony


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