Pumps, Valves & Liquid Handing
Syringe Pumps for Micro-fl uidic and Lab-on-a-Chip Systems
The term lab-on-a-chip refers to a system that accommodates the entire functionality of a macroscopic laboratory on a chip. The micro-fluidic chip with the size of a credit card is usually made of plastic or glass, in which channels for the transport of liquids, analytes or reactants are embedded. Biological, chemical or physical processes can take place that would otherwise only be possible in large reactors with the advantage of small volumes and low consumption of valuable chemicals and a high speed of analysis or reaction. Once a module has been designed, such chips can be produced in large numbers at a low price as a disposable product, e.g. in medical diagnostics.
The functionality of lab-on-a-chip systems is ensured by active components such as microvalves and pumps, and the pumps are needed in order to control the flow rate of liquid constantly, reproducibly and pulsation-free.
Syringe pumps are often applied if low flow rates are needed, but for long-term applications, the syringes previously had to be refilled manually. Spetec GmbH has developed a double-syringe pump in which the first syringe is emptied when the second is filled.
The photo shows the motor unit of Spetec GmbH Symax syringe pump. On the upper carrier plate, the two heads of the syringe holders with the spindle slot underneath can be seen. A quick-release device facilitates a quick replacement of both syringes.
The syringes with 5, 20 and 50 mL (made of polypropylene - PP) can be changed quickly and easily. The flow rates can be varied over a range of 6 orders of magnitude from 30 pL/s to 760 μL/s and several modules can be controlled individually. The control software enables the operation of up to 6 pumps in automatic continuous operation at the same time.
More information online:
ilmt.co/PL/xxx6 58822pr@reply-direct.com Pipetting Solutions Streamline Drug Discovery for Infl ammatory Diseases
Integra Biosciences’ electronic pipetting solutions are helping to improve the efficiency and accuracy of drug discovery at Pharmaxis Ltd. The Australian pharmaceutical company has been using Integra’s ASSIST PLUS pipetting robot, as well as the company’s VIAFLO 96 and VIAFLO 384 electronic handheld pipettes to streamline its development and evaluation of novel drug candidates for the treatment of inflammatory and fibrotic diseases.
Pharmaxis operates a highly productive drug discovery engine, starting from the synthesis and screening of potential targets right through to Phase II clinical trials, so it is important that its labs are equipped with flexible instruments for each stage of the workflow. Ross Hamilton, Research Scientist at Pharmaxis, explained: “We were looking for an all-round liquid handling solution when we came across the ASSIST PLUS pipetting robot from Integra. In combination with 12 channel VIAFLO electronic pipettes, this system has been incredibly useful for all of our pipetting tasks, from compound dilution to preparing microplate reader assays. We use this set-up across almost every stage of the workflow, along with the company’s VIAFLO 96 and VIAFLO 384 handheld electronic pipettes - which we have with various pipetting heads ranging in volume sizes of 50 to 1250 µl - for whole plate filling and transfers.
“The accuracy of these instruments is really good, and pipetting multiple channels in parallel helps to eliminate the risk of human error. We also like the company’s GRIPTIP pipette tips, as we never have to worry about them leaking or falling off, which could potentially disrupt our concentration and hinder accuracy. We’ve been using all three instruments for over two years now, and we operate them every single day - they’ve become the dependable workhorses of the lab.”
More information online:
ilmt.co/PL/E2rG Software Assists Precise Flow Monitoring
Testa Analytical has introduced version 1.4 of its fl owmeter software for continuous monitoring of liquid fl ow from an analytical or preparative HPLC system, peristaltic pump, fl ow chemistry system or mass spectrometer.
Operating in conjunction with the Testa Liquid Chromatography fl owmeter the easy-to-use PC software app enables fast, simple experimental set-up and provides full control of device settings including integration time and calibration factor.
The software app will also report average and minimum / maximum values of the measured fl ow. All fl ow data is automatically stored in fi les that can be processed later using almost any commercial data analysis package.
Conveniently powered via a USB connection, the compact Testa Liquid Chromatography fl owmeter uses a thermal sensor that provides extremely accurate, sensitive, and high-resolution measurement of fl ow in real time. As the sensor is non-invasive it can operate over a wide dynamic range and has been demonstrated to be the perfect real-time fl ow monitoring tool for a growing range of liquid applications.
More information online:
ilmt.co/PL/j6Zv Liquid Cooling Solutions Supporting Automated Applications
Leading provider of reaction control solutions, Inheco, has developed a new portfolio of liquid cooled devices designed to support enclosed systems. Nextgen liquid handling systems are fully enclosed due to regulations and to protect the chemistry from contamination. They provide many benefi ts by eradicating the risk of excess heat and air movement on your automated deck.
Liquid cooling devices have little to no detrimental effect on the deck temperature as the waste heat is transported off-deck by the liquid loop and dissipated via the external heat exchanger. The removal of fans negates the risk of moving air further distributing contaminants in the enclosure. As an extended temperature range is delivered users can keep enzymes at lower temperatures - even sub-zero.
The compact devices deliver space saving in the laboratory, therefore the lower profi le reduces risk of the device impeding movement around the deck. Liquid cooled devices reduce overall noise in the working environment due to the silent operation. The Easy modular installation allows devices to be serially connected. One liquid loop is required for multiple devices with no performance drop.
Contact Inheco to learn more about the CPLC - Heater/Cooler and the Thermoshake AC-LC - an AutoClamping Heater/Cooler/shaker (available Q3). Find the best liquid cooling solution for your laboratory. More information online:
ilmt.co/PL/R2DQ
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