Chromatography 11 High Resolution Microfl owmeter Ensures Reliability of Quantitative LC/MS
Testa Analytical Solutions eK announces the AB-40004 microfl owmeter (µFlowmeter), a non-invasive device designed to provide continuous high precision measurement of low volume liquid fl ows.
Optimised to operate over the fl ow range 0.001 to 80 µL/minute, with an unmatched high resolution of 1nl/minute, the µFlowmeter is the perfect tool for precise measurement of low fl ow rates ensuring the reliability of quantitative HPLC/Mass Spectrometry (LC/MS) measurements.
Compact in size, and conveniently powered via a USB connection, the µFlowmeter is fully compatible with all organic and aqueous chromatography solvents. The affordably price device includes an easy-to-use PC based app which allows continuous recording and storage of the measured fl ow rates. The current fl ow rate is also displayed on the µFlowmeter’s integral high-resolution OLED Display, allowing easy control of current fl ow value. The software app will also report average and minimum/maximum values of the measured fl ow. All fl ow data is automatically stored in fi les that can be processed later using almost any commercial data analysis package.
The µFlowmeter uses a thermal fl ow sensor that is extremely accurate, sensitive, and high-resolution, as well as non-invasive. As the sensor does not interfere with the measurement it can operate over a wide dynamic range and has been demonstrated to be the perfect real-time fl ow monitoring tool for a growing range of liquid chromatography applications.
More information online:
ilmt.co/PL/9x96 59205pr@reply-direct.com
Technical Note: Strategies to Improve Your HIC Analysis
Discover the Future Safety Solution for HPLC Waste
Discover the liquid safety solution of the future, and turn your waste container into a closed safety system! The modular Safety Waste Cap ‘LISA’ blocks chemical vapours with its 3-layered exhaust air fi lter. It connects safely to your HPLC waste lines, and provides safe disposal of chemicals like solvents, acids and alkalis. It comes with multiple connectors for many tubing sizes, and is available for different containers and thread types.
The Safety Waste Cap is made of chemically resistant materials (PTFE and PE-HD) for use with all common chemicals used in analytical labs. The modular system is extendable with accessory ‘Satellites’ for additional connections and applications.
In order to block hazardous vapours and avoid overpressure inside the container, the Safety Waste Cap LISA works perfectly with the original 3-layered SCAT exhaust air fi lters. The fi lters contain 3 types of activated carbon, optimised for catching vapours of solvents, acids and alkalis.
The screw cap is freely rotatable and prevents your HPLC tubing from twisting when changing the container. Due to the variety of included connectors for different tubing sizes, LISA fi ts every HPLC / UHPLC system. To keep the system safely closed, it comes with blind plugs for every connection port.
For use in explosion-protected zones, electrically conductive versions are available. They provide a grounding connection for antistatic protection, and are designed for use with electroconductive containers.
More information online:
ilmt.co/PL/kqEj and
ilmt.co/PL/kqEj
Hydrophobic interaction chromatography (HIC) is a separation mode used for the analysis of biomolecules such as antibody-drug- conjugates (ADCs), monoclonal antibodies (mAbs) or proteins in general. Analytes are separated based on the differences in their surface hydrophobicity similar to reversed phase (RP) chromatography. However, a big plus is that analytes maintain their original structure and therefore functionality, making HIC a useful separation mode for intact protein analysis or protein purifi cation.
HIC utilises reversible interactions that occur between the analyte and hydrophobic stationary phase ligands attached to the particle surface by applying an inverse salt gradient. A high salt concentration in the beginning of the gradient enhances the hydrophobic interactions between the target molecules and the stationary phase resulting in their retention. By decreasing the salt concentration, the strength of the interaction weakens and the analytes elute.
In this new Technical Note from YMC you will learn insights about: How to increase the retention by using elevated temperature and high initial salt concentrations; The infl uence of salt concentration on sample precipitation; Improving hydrophobic interactions by selecting the right pH; How shallower gradients provide higher resolution; The infl uence of organic modifi ers on peak shape and retention.
If you want to know more about the resolving power of non-porous HIC columns for intact proteins, check out this Technical Note.
More information online:
ilmt.co/PL/6l2Q and
ilmt.co/PL/L293
58796pr@reply-direct.com Send your Press Releases to:
pr@intlabmate.com
58792pr@reply-direct.com
Fast & Efficient Sample Dry Down Take control of your sample preparation with an Ultrvap®
nitrogen blowdown
evaporator. This range of benchtop friendly instruments are designed to remove the ‘bottlekneck’ step of sample evaporation in analytical workflows.
• Reproducible Evaporation • High Sample Throughput • Flexible Programming • Automation Friendly
Get in touch to find which Ultravap® instrument is best for your workflow. email:
hello@porvairsciences.com website:
www.microplates.com
WWW.LABMATE-ONLINE.COM
Page 1 |
Page 2 |
Page 3 |
Page 4 |
Page 5 |
Page 6 |
Page 7 |
Page 8 |
Page 9 |
Page 10 |
Page 11 |
Page 12 |
Page 13 |
Page 14 |
Page 15 |
Page 16 |
Page 17 |
Page 18 |
Page 19 |
Page 20 |
Page 21 |
Page 22 |
Page 23 |
Page 24 |
Page 25 |
Page 26 |
Page 27 |
Page 28 |
Page 29 |
Page 30 |
Page 31 |
Page 32 |
Page 33 |
Page 34 |
Page 35 |
Page 36 |
Page 37 |
Page 38 |
Page 39 |
Page 40 |
Page 41 |
Page 42 |
Page 43 |
Page 44 |
Page 45 |
Page 46 |
Page 47 |
Page 48 |
Page 49 |
Page 50 |
Page 51 |
Page 52 |
Page 53 |
Page 54 |
Page 55 |
Page 56 |
Page 57 |
Page 58 |
Page 59 |
Page 60 |
Page 61 |
Page 62 |
Page 63 |
Page 64 |
Page 65 |
Page 66 |
Page 67 |
Page 68 |
Page 69 |
Page 70 |
Page 71 |
Page 72 |
Page 73 |
Page 74 |
Page 75 |
Page 76 |
Page 77 |
Page 78 |
Page 79 |
Page 80
