www.aahanet.org / JOURNAL OF THE AMERICAN ANIMAL HOSPITAL ASSOCIATION
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SOFT T ISSUE SURGERY
Peritoneopericardial Diaphragmatic Hernia: A Retrospective Study of
31 Cats and Eight Dogs AC Banz, SD Gottfried
RETROSPECTIVE STUDY The records of 31 cats and eight dogs undergoing sur- gical correction of peritoneopericardial diaphragmatic hernia (PPDH) from 2000 through 2007 were reviewed. Weimaraners and long-haired cats of varying breeds, particularly Maine Coon cats, appear to be at higher risk of PPDH. Presenting complaints were most commonly related to the respiratory and gastrointestinal tracts in both dogs and cats, although respiratory signs were more prevalent in cats, and gastrointestinal signs were more common in dogs. The most common herniated organs were liver, gallbladder, and small intestine. Mor- tality associated with surgical repair of PPDH in cats and dogs was low in the first 2 weeks postoperatively, and prognosis for return to normal function was excellent. Peri- and postoperative complications were typically minor and self-limiting.
INFECTIOUS DI SEAS E S
Clinical Presentation of 26 Anaplasma phagocytophilum- Seropositive Dogs Residing
in an Endemic Area AW Mazepa, LB Kidd, KM Young, LA Trepanier
RETROSPECTIVE STUDY Anaplasma (A.) phagocytophilum, the etiological agent of canine granulocytic anaplasmosis, is capable of inciting moderate to severe clinical disease in a variety of mam- mals and is endemic in the upper midwest. The purpose of this study was fourfold: to describe the range of clini- cal signs in dogs seropositive to A. phagocytophilum; to examine the prevalence of immune-mediated hemolytic anemia (IMHA) in this population; to evaluate whether specific clinical signs were associated with coexposure to Borrelia (B.) burgdorferi in actively infected dogs; and to determine whether clinical response to doxycycline was complete in treated dogs. Medical records of dogs seropositive for A. phagocytophilum were reviewed ret- rospectively. Peripheral blood smears were also reviewed retrospectively for granulocytic Anaplasma morulae. Lethargy (81%), inappetence (58%), and lameness (50%) were the most common clinical signs, followed by fever (46%). Thrombocytopenia was the most common labora- tory abnormality, and IMHA was diagnosed in three dogs. Dogs that were thrombocytopenic and had antibodies to both A. phagocytophilum and B. burgdorferi had a median platelet count of 51,000/µL (range 20,000 to 171,000/µL), which was significantly lower than the count in dogs with antibodies only to A. phagocytophilum (P=0.04).
Trends magazine, November/December 2010
ONCOLOGY
Treatment of Feline Gastrointestinal Small-Cell Lymphoma With Chlorambucil
and Glucocorticoids TJ Stein, M Pellin, H Steinberg, R Chun
RETROSPECTIVE STUDY Gastrointestinal (GI) lymphoma is the most frequently diagnosed form of lymphoma in the cat and is catego- rized into two distinct forms based on the size of neo- plastic lymphocytes. Treatments for both large- and small-cell GI lymphoma have been described previously; however, multiple chemotherapy protocols were used, a minimal amount of histopathological characteriza- tion was provided, and, in most studies, the majority of diagnoses were obtained via endoscopic pinch biop- sies. Twenty-eight cats (24 with full-thickness intestinal biopsies) were diagnosed with small-cell GI lymphoma and treated with a combination of chlorambucil and glu- cocorticoids. The majority of cases were strongly CD3+, and many displayed epitheliotropism. The overall clinical response rate was 96%, with a median clinical remission duration of 786 days. Follow-up identified seven cats with relapsed disease—all of which were treated with a rescue protocol of cyclophosphamide and glucocorti- coids; the response rate was 100%, and four of the 28 cats were diagnosed with a second malignancy.
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