Superior direct antimicrobial effect The use of organic acids such as formic, acetic, propionic, lactic, citric, or other organic acids has become common practice as a tool to support feed hygiene and digestion in young animals. Research has proven however that esterification of fatty acids to monoglycerides significantly increases the antibacterial activity, bio-effectivity, and molecular stability of SCFA & MCFA’s, making monoglycerides the next generation choice to reduces antibiotics and increase production performances (Table 1). The in vitro antimicrobial effectiveness of capric (C10) and lauric (C12) acid typically increases up to 30 times by esterification of a fatty acid to a monoglyceride. The glycerol moiety renders the fatty acids significantly more antibacterial active thanks to its emulsifying, detergent-like, properties and effect. The typical amphiphilic nature of monoglycerides -meaning that it has a hydrophilic or water-loving head, preferably positioned towards a water- environment, and a lipophilic or lipid-loving tail, preferably positioned towards a lipid-environment- causes disintegration of the bacterial membrane. Another advantage of the monoglyceride form is the pH-independency of the antimicrobial activity. A monoglyceride molecule stays lipid- active in a broad pH range, whereas free acids typically require a low pH to be optimally antibacterial.
Enhance the immunocompetence Improving gut health is not limited to reducing the intestinal microbial load entering the animal through feeding. Mono- (and tri) glycerides of butyric acid are thoroughly investigated over the last years and are seen as the most effective tool to improve gut health by naturally stimulating mucosal maturation. The mucosal barrier is further fortified by MCFA monoglycerides which are positively modulating the immunity i.e., boosting animals’ defence mechanisms and avoiding unnecessary -energy costly- gut inflammation.
Strategic use to promote animal health As 60% to 80% of antibiotic usage is estimated to be related to gut health issues, it is crucial for the industry to increase gut health from the very first days. Supplementing monoglycerides from the start offers a multi-targeted approach with many benefits and no disadvantages. It provides a superior direct and selective antibacterial effect, an indirect pathogens defence effect and an optimised gut health and resilience effect, thereby optimising performance and preventing diseases. The scientifically proven and cost- effective added value of esterification makes monoglycerides the right and popular choice to reduce antibiotics and optimise animal health.
Table1 – Key benefits of monoglycerides in the fight against antimicrobial resistance. Antibiotics
Monoglycerides Molecular origin Antimicrobial inhibitory spectrum Positive effect in the animal Chance to develop antimicrobial resistance
Synthetic biology Broad range
Collateral damage of beneficial bacteria Necessity to recover after antibiotic treatment Non-selective bacterial suppression
High
Esterification technology High selectivity
Positive impact on the microbiome Microbiome resilience
Microbiome balancing effect •Gut development, maturation, and protection •Mucosal immunity training Neglectable
▶ ANTIBIOTIC REDUCTION | DECEMBER 2021 91
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