Antibiotic resistance: Breaking the cycle
Antibiotic resistance could become one of the greatest problems of our generation, given the increasing rise in bacterial strains that are less sensitive to existing treatments. While abuse of antibiotics in humans is probably the major contributor, policymakers have turned the spotlight on agricultural use as a way to control the problem.
BY DR RICHARD MURPHY, ALLTECH E
Chromosomal DNA
RESISTANT BACTERIA Pilus attaches to non-resistant strain
ach year, the ECDC and EFSA produce a summary report on antimicrobial resistance in zoonotic and indicator bacteria from humans, animals and food. Such data reveals some interesting insights and
highlights the occurrence of resistance to commonly used antimicrobials in veterinary medicine in carcasses of food- producing animals. The report for 2018/2019 indicates that among Salmonella spp. recovered from broiler carcasses, resistance to the
Figure 1 - MRF reduces spread of antimicrobial resistance. How Antibiotic Resistance Spreads
Plasmid DNA with resistance genes
Pilus How MRF Reduces the Spread of Antibiotic Resistance
Chromosomal DNA
Plasmid DNA with resistance genes
Pilus
fluoroquinolone antimicrobial agents ciprofloxacin and nalidixic acid was reported at high to extremely high levels in many member states in the EU, with overall resistance at 51.4% and 48.8%, respectively. Information concerning the antimicrobials ampicillin, sulfamethoxazole and tetracycline is equally noteworthy. As high-priority, ‘critically important antimicrobials’ (CIAs) and ‘highly important antimicrobials,’ it is of concern that overall resistance to them remained very high among Salmonella spp. recovered from poultry carcasses in the most recent report
NON-RESISTANT BACTERIA
RESISTANT BACTERIA MRF introduced
NON-RESISTANT BACTERIA
RESISTANT BACTERIA
NON-RESISTANT BACTERIA
Copy of resistance genes transfers to non-resistant strain
RESISTANT BACTERIA
MRF
MRF prevents Pilus attaching MRF
NON-RESISTANT BACTERIA
RESISTANT BACTERIA
NON-RESISTANT BACTERIA Both strains now resistant
RESISTANT BACTERIA
NON-RESISTANT BACTERIA SPREAD OF RESISTANCE IS PREVENTED
RESISTANT BACTERIA
RESISTANT BACTERIA
RESISTANT BACTERIA
NON-RESISTANT BACTERIA
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▶ ANTIBIOTIC REDUCTION | DECEMBER 2021
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