Why is the use of monoglycerides so popular?
The direct supplementation of high purity monoglycerides to feed and/or water is a popular and emerging nutritional practice. Its popularity may be down to it having many benefits and no disadvantages.
DR JULIE FEYAERTS, PRODUCT DEVELOPMENT MANAGER, PROVIRON T
he direct supplementation of high-purity monoglycerides to feed and/or water is a popular and emerging nutritional practice. Monoglycerides of short chain and medium chain fatty acids (SCFA &
MCFA’s) have a well-documented direct in vitro antimicrobial activity and are known to enhance the immunocompetence of animals. Monoglycerides improve animal gut health and reduce the risk of disease transmission in the post-antibiotic era.
Proviron monoglyceride technology
Monoglycerides are formed out of one glycerol molecule and one fatty acid molecule. In the high-tech Proviron esterification process, glycerol and free fatty acids (from C3 to C12) are covalently bound to form heat and processing stable, non-smelling, pH-independent and superior antimicrobial active α-monoglycerides.
α-Monoglyceride -OH -COO H
The fight against pathogens Antibiotics are defined as medicines that destroy micro- organisms or inhibit their growth. Globally, antibiotics are used in livestock production for two main reasons: to treat diseases (short time, high dosage) and to promote the growth of animals (in-feed, low dosage). The curative use is intended to cure animals that typically suffer from a bacterial infection. The “antibiotic growth promoter” (AGP) use is intended to boost growth and feed efficiency in an intensified animal husbandry industry. Since the antibiotic ban in 2006 in Europe -related to the global health threat of antimicrobial resistance- alternative (nutritional) strategies have been developed and successfully implemented to promote animal gut health and to optimise production performances. Adopting a higher level of biosecurity and implementing higher value feed formulations are the new standard to replace or reduce AGPs. The effect of adding monoglycerides to feed formulations or drinking water systems has been intensively studied and tested. It is proven to be a very effective tool to help reduce the antibiotics usage by stimulating gut development, gut maturation and gut protection, and by improving the immunocompetence of animals.
Glycerol Covalent bond Lauric acid
Glycerol monolaurate Monolaurin
90 water
Monoglycerides are inspired by nature Monoglycerides are naturally present in mothers’ milk with the aim to be biologically active along the entire intestinal tract. They are highly valued as bio-functional molecules to stimulate mucosal immunity maturation and gut development in the offspring. The antimicrobial activity of the monoglycerides of f.e. caprylic (C8), capric (C10) and lauric (C12) acid covers a wide range of pathogens, such as Gram-positive and Gram-negative bacteria, lipid-enveloped viruses, algae, fungi and protozoa. Monoglycerides are known to have a strong bacteriostatic (inhibiting) and bactericidal (killing) effect. A major benefit of monoglycerides compared to antibiotics is the fact that monoglycerides have a high selectivity of pathogen elimination, whereas antibiotics have a broad range antibacterial activity thereby also destroying beneficial gut microbiome bacteria. Different monoglycerides or combinations of monoglycerides can therefore target and suppress specific pathogen problems in a farm and boost rather than destroy beneficial bacteria.
▶ ANTIBIOTIC REDUCTION | DECEMBER 2021
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