Lysophospholipid supplementation for gut health


Dietary supply of lysophospholipids (LPL), which naturally occur in cell membranes at 0.5-6%, has been shown to improve nutrient absorption in the small intestine, improve gut health, support intestinal development including tight junctions and reduce free/excess nitrogen.


BY PHILIP VERNON, NUTRITIONIST AND AREA MANAGER (NORTHERN EUROPE) OF PATHWAY INTERMEDIATES LIMITED


F


Treatment PC


PC + 0.025% LU PC + 0.05% LU PC + 0.075% LU NC


NC + 0.025% LU NC + 0.05% LU NC + 0.075% LU


ollowing the ban on antibiotic growth promoters (AGPs) plus the move to reduce the use of other anti- biotic products, the feed industry has continued to research alternatives coupled with other strategies,


including higher welfare standards, to optimise livestock per- formance. There has been a year-on-year reduction in the amount of antibiotics used. This reduction has been accom- panied by a multi-pronged approach including reviews of farm management and feed strategies, for example. The ini- tial alternatives included organic acids, pre and probiotics


Table 1- LPL supplementation shows positive correlation to feed conversion and mitigating dietary energy losses. LU refers to LPL content.


BWG (g) 2,337.63BC 2,379.38AB 2,392.42AB 2,500.03A 2,195.17D 2,343.31BC 2,220.40CD 2,188.92D


FI (g)


4,074.66B 4,030.31BC 3,961.52BCD 4,346.46A 3,847.76CD 4,066.68B 3,794.39D 3,837.50CD


A-D Within a column with different superscripts are significantly different (p<0.05). 82 ▶ ANTIBIOTIC REDUCTION | DECEMBER 2021


FCR 1.74 1.69 1.66 1.74 1.75 1.74 1.71 1.75


and Medium Chain Fatty Acids (MCFA’s), which gave an excel- lent base to where we are today. The target for additional re- ductions by 2024, however, will require further investigations.


Research on lysophospholipids Pathway Intermediates R&D team have been researching the use of lysophospholipids in animal feed, publishing 18 articles focussing on broilers alone. One recent study into dietary supplementation up to 0.075% LPL has been shown to improve a wide range of gut health parameters. For example, an increase in small intestine nutrient absorption: this included a 5% increase in nitrogen uptake (Crude Protein CP and Amino Acid AA) leading to a reduced nitrogen output. This improved absorption was confirmed from the positive changes in the intestinal wall structure: improved villi height and crypt depth. The thinning of the mucosal layer also adds to the improved absorption plus is an indicator of a positive impact on gut health: a change in microbial levels and/or populations. A recent study at the University of Georgia, USA, investigated Pathway Intermediates lysophospholipid product. The investi- gation used lysophospholipid dietary levels of control (0%), 0.025%, 0.05% and 0.075% LPL supplementation. The assess- ment was carried out with 960 Cobb 500 male birds: day-old to 41 days of age. This study is an example of our routine R&D programme. The investigation was a 2×4 factorial design, with two energy levels positive control (industry guidelines (PC)) and negative control (lower energy -100kcals (NC)) plus four concentrations of LPLs. The data covered bird performance, carcass yield, tight junction proteins, bone ash and Intestinal histology.


Overall performance The feeding of a reduced energy diet might be expected to result in a higher feed intake and slower growth rate from day old through to slaughter. A positive correlation, however, be- tween energy level and LPL supplementation was observed on body weight gain (p<0.0378) and feed intake (p<0.0058) over the trial period (Table 1).


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