performance at a similar or greater level when compared with dietary antibiotics (chlortetracycline + tiamulin). An experiment in broilers has shown a similar result, indeed, broiler chickens fed a corn-based diet supplemented with 1% of L-glutamine exhibited higher performance than chickens treated with bacitracin both in challenged and unchallenged conditions. It is worth noticing that in the addition to benefits in terms of performance, glutamine supplementation was consistently associated with an improvement of gut morphology, an increase in circulating immunoglobulins and a reduction of inflammation markers.
Synergistic amino acid solutions Studies show there is little doubt concerning the efficiency of L-glutamine supplementation to improve gut health. However, all experiments tested glutamine at high doses (from 0.2 to 2%) preventing this strategy to be implemented on the field. Synergistic solutions combining glutamine with other functional amino acids are promising and has been shown to (i) increase the efficiency of the solution (ii) decrease the dose of efficiency (iii) increase the reproducibility of the results. For example, we have shown in two different commercial experiments that the supplementation of 0.1% of an amino acid-based solution containing L-glutamine, L-cystine and L-arginine can significantly reduce by one third the use of individual antibiotic treatments in post-weaning piglets. In addition, in a recent study, we observed that the supplementation of a similar solution (Inneus piglets for gut health) during the prestarter phase could reduce diarrhoea score and improve growth of the piglets. In broiler chickens, we demonstrated that the supplementation of 0.1% of an amino acid-based solution containing L-glutamine, L-threonine and L-arginine (Inneus chickens for gut health) could improve the performance of chickens challenged with coccidiosis at the same level as chickens treated with an anticoccidial drug (Figure 2). Similar effects could be
Effect of anticox treatment or Inneus supplementation on performance of coccidiosis-challenged chickens
75 73 71 69 67 65 63 61 59
b a b
1.45 1.40
1.30 1.35
1.25 1.20 1.15 1.10 1.05 1.00
Infected
Infected + Anticox
Infected + Inneus chickens
observed in necrotic enteritis challenged chickens (Figure 2).
Complementary approaches for success Reducing antibiotic use down to zero is a long and complex journey. The growing portfolio of feed-grade amino acids now allows, on one hand, to decrease dietary crude protein level efficiently and reduce the excess of undigested protein and, on the other hand, to supplement the adequate nutrients to boost particular physiological functions such as gut health. We believe these complementary nutritional strategies should be combined and are efficient tools in a context of antibiotics use reduction.
References are available on request. Figure 2 - Inneus supplementation is efficient to promote performance of challenged broilers.
Effect of amoxicillin treatment or Inneus supplementation on performance of necrotic enteritis-challenged chickens
75 73 71 69 67 65 63 61 59
1.45 1.40
1.30 1.35
b b a
1.25 1.20 1.15 1.10 1.05 1.00
Infected
Infected + Amoxicillin
Infected + Inneus chickens
▶ ANTIBIOTIC REDUCTION | DECEMBER 2021
73
Body weight gain (g/d)
Body weight gain (g/d)
PHOTO: STEPHEN AUSMUS
Feed conversion ratio (g/g)
Feed conversion ratio (g/g)
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