Tight junctions Tight junctions are usually ignored outside of the first 12 hours of life, perhaps except for issues with leaky gut syn- drome. Their strength is often taken as an indicator of ideal intestinal wall structure and gut health. An assessment of tight junctions was carried out on day 7 and 21. Claudin-3 protein is a universal tight junction protein and is considered a marker for determining tight junction in- tegrity. The LPL supplementation at 0.05% and 0.075% signif- icantly (p<0.05) increased claudin-3 protein expression in the duodenum compared with the other treatments at both en- ergy levels. This positive effect at both energy levels is en- couraging if birds are under nutritional intestinal stress.
Intestinal morphology Changes in villi height and crypt depth are common factors used in determining the effectiveness of a product on diet di- gestibility and absorption. Stunting of villi in the early stages of growth have been reported to decrease overall perfor- mance through reduced absorption. An assessment on day seven indicated that supplementation with LPL at 0.05% and 0.075% significantly increased (p<0.05) villi height compared with the other treatments, at both energy levels. An increased villus to crypt ratio is
correlated with an improvement in the level of digestion and absorption of nutrients. This combined with increased intestinal strength and health provide a positive step in animal health.
Improved absorption In conclusion, the supplementation with LPL, has been shown to support a healthy digestive system statistically at both 0.05% and 0.075% dietary inclusion. The positive change in digestion and gut health was a combination of different effects across both energy levels. The increase in villi height would offer an insight into improved absorption. In addition, the changes to the intestinal walls would further improve digestion and absorption. Furthermore, the increase in claudin-3 protein levels would be an indicator of a more stable gut integrity, even at reduced dietary energy levels. The improved absorption and intestinal structure/integrity led to the expected improvements in performance: body weight gain and a comparable feed conversion ratio. Pathway Intermediates R&D is continuing to confirm that supplementation of broiler diets with lysophospholipids is a valuable addition to maintain performance and gut health within the increasing requirement to find ideal cost-effective alternatives to antibiotics.
▶ ANTIBIOTIC REDUCTION | DECEMBER 2021 83
Lysophospholipid supplementa- tion can help maintain perfor- mance and gut health in broilers.
PHOTO: EASY BIO
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