Pooled plasma Animal based proteins are valuable feed ingredients. Especially SDPP has an outstanding record of improving performance in young piglets. The mentioned studies show that weaned piglets have the same performance when zinc or antibiotics are replaced by SDPP. The beneficial effects relate to the high digestibility and palatability of the plasma proteins, but more importantly to the immune-active peptides in the plasma. Especially the immunoglobulins which have a local protective effect at the gut wall. The immunoglobulins prevent that ingested pathogens can colonise, infect the animals or disturb the gut microbiota. The SDPP on the market is a product of pooling, bringing all possible antibodies together. Consequently, the plasma pool is effective against many endemic viruses and bacteria circulating in the pig population, giving protection against any common pathogens that pose a risk for young animals. It is interesting to note that in numerous virus safety studies undertaken by the blood product producers, the mechanisms constituting the beneficial effect of SDPP becomes tangible. Neutralising antibodies present in pooled plasma prevents the infection of studied viruses in cell culture assays and in piglet bioassays, for example for circo-virus (PCV2), parvovirus and corona viruses. Because of the antibodies in SDPP fed to piglets, bacteria and viruses will neither infect the cell, nor colonise the gut. In this way infection is prevented and unbalancing of the


microbial ecosystem will be less likely. Besides the local gut effect, studies suggest that there are also systemic health effects. One of the things observed is that SDPP fed piglets had a stronger protection after vaccination against respiratory diseases compared to non- SDPP fed piglets. In the body the different lymphoid tissues in different parts of the body (gut, lung, skin etc.) are inter- connected. The SDPP will first affect the gut associated lymphoid tissue and therefore there is also an effect on the lymphoid tissues in other parts of the body. Critical or transition periods in juvenile life are also seen in poultry and aqua culture. The number of studies in these animal species is increasing. And also, in these species antibiotics are applied to overcome the challenges at the critical transitional stages of live. Young chicks grow faster and less mortality is seen in shrimp with feeds that contain SDPP.


Conclusion To increase the sustainability of animal production it is necessary to reduce the reservoir and selection of resistant bacteria. Using plasma as a feed ingredient shows to improve the health of young animals. Therefore, spray-dried plasma can be a part of the solution in reducing the need for antimicrobial treatments.


References available on request. ▶ ANTIBIOTIC REDUCTION | DECEMBER 2021 19


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