Drug Discovery & Pharmaceuticals
Pipetting Solutions Accelerate Neurodegeneration Research
Integra’s VIAFLO 384 handheld electronic pipettes are aiding scientists at Rejuveron Vascular Therapeutics AG, a company specialising in the development of therapies to tackle neurodegeneration, to accelerate their research. Combining this convenient benchtop system with endothelial cells cultured in Corning® HTS Transwell® 96 well plates allows the team to investigate the ability of drugs to penetrate the blood brain barrier (BBB). Vasco Ledebur de Antas de Campos, Head of Discovery Biology at Rejuveron Vascular Therapeutics, explained: “We deposit cells in the Transwells, and incubate them to form a monolayer on the filter membrane in each well. Once we have obtained high confluency - which simulates the BBB - we administer the drug candidates.”
“We use a VIAFLO 384 - with a 96 channel head and 125 µl Sterile Filter GripTips - to both deliver the drugs to the apical side and take samples from the basolateral side of the Transwells. This allows us to check the amount of each drug that was able to permeate the barrier. This approach would be difficult to perform with a standard multichannel pipette, as we are often screening large libraries. In contrast, it’s a simple task for the VIAFLO 384, since you can easily program the system to aspirate from any part of the well.”
“I love working with the VIAFLO 384. The system is easy to set up and optimise and, in addition, it is very flexible. For example, you do not need to load the whole deck, but can use just a single column or row, which means that we can use the system to set up and study dose responses,” Vasco concluded.
More information online:
ilmt.co/PL/Ppn0 57497pr@reply-direct.com
Accelerating Academic Drug Discovery with Evaporator Technology
The renowned Chemistry Research Laboratories (CRL) at Oxford University are using several Smart Evaporator C1 units from BioChromato Inc to support their drug discovery activities in therapeutic areas, including oncology and regenerative medicine.
The Smart Evaporator C1 units, ably supported by local agent, Asynt, have found wide ranging use by the medicinal chemistry team. Critical to the BioChromato evaporator selection was their ability to effectively remove trace solvents with researchers needing, daily, to remove solvents from target compounds prior to submitting them to their biology colleagues for screening. In addition, CRL researchers commonly employ their Smart Evaporators for isolating synthetic intermediates, and recovering NMR samples from solution, including those containing high boiling solvents such as DMSO.
An Oxford University spokesperson commented: “The Smart Evaporators not only help with our workflow, but importantly are quick and easy to use, require little or no maintenance, and occupy only a small footprint within a fume hood.”
Designed to be highly reliable and easy to use, the Smart Evaporator C1 is an affordably priced benchtop system proven to safely and efficiently concentrate or dry single samples directly from both tube and vials. Drawing upon patented Spiral Plug™ evaporation technology, the compact, benchtop Smart Evaporator C1 offers fast and effective evaporation in tubes or vials without solvent bumping thereby eliminating risk of sample loss, cross contamination and saving researcher’s time. The Smart Evaporator C1 is optimised to handle solvent volumes up to 40 mL which can be extremely useful for concentrating compounds after organic synthesis or drying analytical samples at relatively high speeds. The versatile C1 can also take small tubes and vials where solvent volumes can be as little as 0.1ml.
More information online:
ilmt.co/PL/PpmJ 57160pr@reply-direct.com
Stackable Microplates for Space Optimisation
Low profile microplates from Porvair Sciences offer the highly efficient use of stacking space that is essential to achieving efficient automation workflows.
Designed to deliver a sample volume of 0.5ml/well in a plate height of just 27mm, these low-profile 96-well microplates are ideal for a wide range of pharmaceutical, biotechnology and healthcare storage applications. Precisely manufactured to comply with ANSI/SLAS dimensions these high-quality plates are fully compatible with all manual and robotic sample handling systems.
Requiring 30% less space than standard 96-well deep well microplates, Porvair low profile microplates optimise storage space, thereby also lowering the unit cost of cryogenically storing samples.
Available sterile or non-sterile, Porvair low profile 96-well deep well microplates are manufactured from RNase/DNase-free, low leachables polypropylene that undergoes extensive quality testing to ensure a product of the highest quality.
Offering high chemical and temperature resistance (-196°C to +121°C) the design of these autoclavable low profile microplates includes a U-bottom to enable maximum liquid uptake, alphanumeric well coding for easy sample tracking and raised well rims to enable easy, high integrity sealing.
More information online:
ilmt.co/PL/mggk 57470pr@reply-direct.com
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