Chromatography 15 New SPE Filter for Faster Sample Loading


GL Sciences has introduced a new SPE filter, the EZ Cartridge RP-1. Using this filter, the sample loading time is much faster compared to conventional cartridges. Using a combination of PTFE fibres and our RP-1 polymer (methacrylate-divinylbenzene), a 0.5mm thick layer is created. Due to this thin layer, sample loading times are 5 times faster. The particle diameter is only 10µm, creating a large surface area for the analyte to interact with. While having a very thin layer, the small particle size results in the analyte to not break through the SPE layer.


EZ Cartridge RP-1 can best be used in the analysis of pesticides in water. the flow rate of a sample through a typical SPE cartridge is 10-20 mL/min, whereas the EZ cartridge can be used with speeds of 100 mL/min. It will show sufficient recovery of the compounds of interest.


EZ Cartridge RP-1 is a hydrophobic SPE cartridge, in functionality comparable with the well-known HLB cartridges. It is ideal for working with watery samples, whether small or large quantities are available. For more information and the pesticide application, please visit the website.


More information online: ilmt.co/PL/a9V5 57435pr@reply-direct.com


GC Range Available at Affordable Monthly Payments


Ellutia Chromatography Solutions can now offer a range of monthly payment options for UK customers looking to purchase a GC. Leasing or Hire Purchase means companies do not need to make a large capital outlay and could further benefit from potential tax savings. The already low entry price of the 200 series Gas Chromatograph combined with a range of funding options makes GC Analysis affordable to more laboratories without sacrificing analytical performance. Systems can be configured for manual injection or a range of autosampler options can be added.


The 200 Series Gas Chromatograph from Ellutia is a compact high-performance GC at an affordable price making gas chromatography accessible to every lab. Originally designed for use in education, the 200 Series GC is simple to operate with rugged construction making it the ideal first GC for scientists looking to start Gas Chromatography. The analytical performance however matches much larger costlier instruments from other manufacturers meaning it is just at home in a commercial lab as it is in the classroom.


More information online: ilmt.co/PL/Lq4w 56515pr@reply-direct.com


ADVERTORIAL


Advanced Chromatography Modelling and Optimisation Software S-Matrix Corporation, the developer of the Fusion QbD®


Software Platform, announces new automated peak tracking features and capabilities to support Forced


Degradation Studies. S-Matrix was the first company to develop closed-loop experiment automation for Chromatography Data Software (CDS) with integrated Design of Experiments (DoE) methodology for LC method development and validation. S-Matrix was also the first company to integrate true Monte Carlo robustness simulation into chromatographic method development and optimisation software.


S-Matrix has now coupled its powerful PeakTracker™ technology for automated UV and MS spectra based peak tracking with a fully automated workflow for Forced Degradation Studies (FDS) within Fusion QbD. To engage the FDS feature you simply set up your method development experiment as usual, and then enter the degradation paths which yielded peaks in the simple setup window pictured in Figure 1. Note that in this example only the Oxidation path yielded degradant peaks. As also shown in Figure 1, Fusion QbD will automatically replicate each experiment run to accommodate the compound mix sample (the sample containing all expected peaks) and the additional degradation path sample(s). It will then automatically assign a separate autosampler vial position to each replicate injection when exporting the design to the CDS.


Once the experiment is run in the CDS, Fusion QbD will automatically import the results for each peak in each replicate injection for each experiment run. PeakTracker will then track all peaks in all replicate chromatograms for each run. Once the peaks are tracked, PeakTracker will generate a composite chromatogram for each run containing all unique peaks from the sample compound mix injection and from the replicate degradant path injections, as pictured in Figure 2. All peak results data for each included peak are automatically aggregated into the peak data set for the composite chromatogram generated for each experiment run, and this data set is then used for the rest of the experiment workflow, including data modelling, robust method optimisation, Method Operable Design Region (MODR) visualisation, and chromatogram simulation.


®


Figure 1. Fusion QbD will automatically replicate each experiment run to accommodate the compound mix sample and the additional degradation path sample(s).


Fusion QbD Software Platform Analytical Quality by Design / Analytical Procedure Lifecycle Management Suite


• Flexible Design of Experiments (DoE)


• CDS Experiment Automation


• Forced Degradation Study Automation


• Automated Peak Tracking


• Chromatography Modeling — All Critical Performance Characteristics


Figure 2. PeakTracker will generate a composite chromatogram for each run containing all unique peaks from the sample compound mix injection and from the replicate degradant path injections.


More information online: ilmt.co/PL/RWWO and ilmt.co/PL/Yggp


57465pr@reply-direct.com Visit us in Hall A3, Booth 123


• Robustness Simulation Covering the Full Experimental Region


• Full Characterization of the Method Operable Design Region


• Full Support for 21 CFR 11 Compliance


• Full Cross-Platform Data Integrity


• Supports All Separation Modes:


RPC, NPC, Chiral, HILIC, IEX, SEC, SFC, …


• Supports Non-LC Method Development:


Sample Prep, GC, CE, Dissolution, …


• Replication Strategy Optimization


• Automated Validation and Transfer Studies


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