Chromatography 9
Ultra-Fast GC can Help Make Testing Labs More Profi table and Sustainable
Analytical Testing Laboratories are seeing ever growing numbers of sample. A highly competitive marketplace means end users are demanding faster turn- around times and lower analysis costs. This means companies need to look at the latest techniques and technology available to ensure they can offer the best service at a competitive price, whilst still achieving good profi tability and operating a sustainable business.
One technique that can greatly increase sample throughput is Ultra-Fast GC. The Term has been banded around recently with some manufacturers even claiming a conventional GC with 2 channels is Ultra-Fast, So what really is an Ultra-Fast GC? A True Ultra-Fast GC directly heats the analytical column rather than using a conventional air blown oven. This offers several distinct advantages a conventional air blown GC cannot. The column can be heated at much faster ramp rates, this can help sharpen peaks and decrease analysis time. As only the column is being heated rather than an entire oven the cool down time is greatly decreased, this means that the injection-to-injection cycle time can be a fraction of that of a conventional GC. Directly heating the column rather than an entire oven also mean signifi cantly less energy is consumed per sample, helping companies further reduce their Carbon Footprint and meet their sustainability goals.
Ellutia has been a pioneer in Ultra-Fast GC technology for over 20 Years. The latest 500 Series GC is an innovative new design that can switch between operating as a conventional air-blown GC with regular fused silica column to an Ultra-Fast GC that directly resistively heats a metal column. The 500 Series GC features a compact footprint that means several GC’s can fi t under a single autosampler further increasing the sample throughput of a system.
More information online:
ilmt.co/PL/9DZy 56514pr@reply-direct.com
Robust and Reproducible Sample Preparation for LC/MS Porvair Sciences has published an in-depth application report demonstrating how their Microlute®
CP
Reverse Phase Solid Phase Extraction (SPE) microplates provide a robust and highly reproducible SPE LC-MS sample preparation methodology for a range of neutral, acidic, and basic analytes.
As a sample preparation method, Solid Phase Extraction is widely acknowledged as a ‘go to’ tool for the clean-up of samples before analysis by hyphenated techniques such as LC/MS or GC/ MS. Solid Phase Extraction offers several advantages to the analyst, including less system downtime and troubleshooting, cleaner chromatograms with a reduction of contaminating compounds, and greater reproducible analyte recoveries. Unfortunately, traditional SPE methods rely upon loose-fi lled resins which often create problems such as voids in the sorbent beds leading to channelling and inconsistent fl ow-through of solutions. These undesirable effects lead to reduced interactions between analytes and the active resin resulting in inconsistent results and poor analyte recovery.
Designed to overcome these shortfalls, Microlute® CP SPE microplates from Porvair Sciences, incorporate a unique, polymer
structure made up of an interconnected network of evenly distributed pores combined with retentive media. This hybrid technology ensures even liquid fl ow rates throughout the SPE process, which leads to suffi cient time for Van der Waals forces of interaction to take place between the solid phase sorbent and the analytes resulting in a highly reproducible SPE method.
Experimental data is provided in the application report to show how Microlute® CP RP 96 well microplates selectively retain and
elute a wide range of neutral, basic and acidic compounds. The data demonstrate how percentage relative standard deviation values from the Microlute®
offer signifi cant benefi ts for the recovery of hydrophobic basic analytes. Read the application report in full:
ilmt.co/PL/9pKn More information online:
ilmt.co/PL/6pw3
CP are on average signifi cantly lower than using other commercial SPE plates, thereby producing more
reproducible results. In addition, the application notedemonstrates that no analyte is lost in the load step of the SPE process leading to high recovery values for all types of compounds. The Microlute®
CP RP 96 well-plate for solid phase extractions is also shown to
57154pr@reply-direct.com
F-DGSi- SMART SOLUTIONS WITH “GEN SECURE”
SECURE Continuous Monitoring of HPLC Pump Performance
Testa Analytical Solutions eK reports how a leading European manufacturer of Chromatography Instrumentation is using its Liquid Chromatography Flowmeter to further improve performance of their top notch HPLC Systems.
Flow rate is a critical parameter in HPLC systems, it determines retention time or volume and therefore has a major infl uence on reproducibility. The Testa Analytical Liquid Chromatography Flowmeter has set a new standard for non-invasive measurement of fl ow rate in HPLC, GPC/SEC and Ion chromatography systems.
Jeannette Ziemba of Testa Analytical commented: “All this begun with a simple inquiry from the client, interested in a high-performance device to obtain accurate values of fl ow rate in real time. They found the possibility to continuously monitor extremely low fl ow rates in combination with the ease of use of our fl owmeter software app to be attractive. They ordered as soon as they got the technical specifi cations. Feedback from the customer is that they are very happy with the reliability, ease of use and performance of the liquid chromatography fl owmeter. In fact, so much so, that they are investigating the possibility of integrating our fl owmeter technology into future HPLC systems to provide real-time monitoring of fl ow.”
Conveniently powered via a USB connection, the compact Testa Analytical liquid chromatography fl owmeter uses a thermal sensor that provides extremely accurate, sensitive, and high-resolution measurement of fl ow in real time. As the sensor is non-invasive it can operate over a wide dynamic range and has been demonstrated to be the perfect real-time fl ow monitoring tool for a growing range of liquid chromatography applications.
More information online:
ilmt.co/PL/MBa0 57443pr@reply-direct.com MODULAR ADVANCED REMOTE CONTROL TRUSTED N2 COSMOS GAS GENERATORS FOR GC
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