18 Why a Reference with a Calibration Certifi cate is not Necessarily a CRM


Instrument qualifi cation using CRMs from an appropriately accredited supplier is the fi rst step towards data integrity. Indeed, the choice of CRM supplier is as important as the choice of CRM. A supplier’s Schedule of Accreditation should be checked to confi rm that it includes the reference material to be purchased - it may not,


Furthermore, it is now recommended that instrument qualifi cation measurements are conducted over the operational range required for the analysis. A laboratory performing measurements over a wide wavelength or photometric range will likely require several different CRMs to cover each instrument parameter.


According to ISO, a fully accredited CRM supplier should be accredited to both ISO 17034:2016 and ISO/IEC 17025:2017 Standards.


In 2001, Starna Scientifi c became the fi rst company worldwide to achieve ISO/IEC 17025 accreditation for the calibration of liquid and glass CRMs for UV-visible spectrophotometry, and in 2006, the company became the fi rst and only supplier of spectrophotometry references accredited to both standards.


All Starna’s CRMs are supplied with a certifi cate showing the traceability of the certifi ed value to Standard Reference Materials (SRM) and a statement of the measurement uncertainty, as required by the ISO defi nition of a CRM.


Starna Scientifi c are committed to the process of continuous improvement demanded by those standards and look forward to another 20 years as the preferred supplier to many of the leading pharmaceutical companies, instrument manufacturers and accredited laboratories worldwide.


More information online: ilmt.co/PL/LVEw 55371pr@reply-direct.com


New Quadrupole Analysers for Vacuum Process Analysis


Hiden Analytical introduce the HPR-30 Series quadrupole analysers for vacuum process analysis. The Hiden HPR-30 Series are bolt on vacuum process analysers designed for fast response, high sensitivity analysis of gas and vapour species. Equipped with Hiden’s multi-level software package, offering simple control of mass spectrometer parameters and complex manipulation of data and control of external devices. Applications include leak detection, contamination monitoring, process trend analysis and analysis of high mass species and precursors used in ALD and MOCVD.


Standard mass range is 200 amu, versions up to 1000 amu are offered.


Optional upgrades include the innovative Hiden 3F series triple fi lter quadrupole system providing enhanced abundance sensitivity, part-per-billion (ppb) detection levels and high contamination resistance, particularly suited to the analysis of aggressive gases in CVD and RIE applications. Standard mass range is 200 amu, versions up to 1000 amu are offered.


Multiple sampling confi gurations are offered to suit a full range of process pressure and vacuum system geometry requirements. Versions are offered with single, or multiple sampling inlets, either unheated or heated to allow sampling of volatile species.


Systems are offered cart mounted, and with height adjustment for maximum compatibility between tools. For pulsed deposition processes, time resolved measurements are offered to 50 ns time resolution.


The HPR-30 Series are designed to offer a fully featured, fl exible and powerful solution for the monitoring of parameters in all aspects of process gas analysis such as leak detection, vacuum quality and precursor monitoring.


More information online: ilmt.co/PL/Xke0 56988pr@reply-direct.com


Quantitative Benchtop NMR Optimises Battery Electrolytes


NMR spectroscopy characterises the chemical structure of battery electrolyte solvents and additives. Importantly, quantitative broadband benchtop NMR additionally determines the precise concentrations of solvents, trace impurities, additives, and decomposition products. In a new application note, Oxford Instruments highlight the relevant quantitative NMR (qNMR) experiments and their importance for optimising next generation battery performance, raw materials checking and improving quality control.


For non-destructive investigations of the chemical nature of materials in the liquid state, NMR spectroscopy is an extremely versatile method employed extensively in research and development. NMR provides information about individual atoms within the compounds, including not only their chemical environment and molecular structure, but also on their quantity. This makes the technique an ideal tool for rapid reaction monitoring and quality control. In an NMR spectrum, the areas under peaks are directly proportional to the number of the atom(s) they are generated from. Quantitative NMR (qNMR) determines the ratios or absolute concentrations of species in a sample.


Visit the Oxford Instruments website to read the full application note. More information online: ilmt.co/PL/1DMW


56346pr@reply-direct.com


New Mass Spec Portfolio Accelerates Quantitative Analysis


The Thermo Scientifi c TSQ Plus triple quadrupole mass spectrometer (MS) portfolio increases workfl ow throughput through superior data acquisition and polarity switching speeds. The improved low-mass product ion transmission effi ciency enhances sensitivity for key target applications. The new portfolio, which consists of the TSQ Altis Plus, TSQ Quantis Plus and TSQ Fortis Plus MS, can be used across a range of applications, from targeted quantitation to cutting-edge research. Intuitive mass calibration routines and method optimisation, in combination with market-leading chromatography and data processing software solutions, offers improved ease of use to address future analytical challenges.


“Laboratories performing routine quantitative experiments continue to need to identify new compounds of interest across industries, such as pharma, food and environmental, resulting in rapidly changing regulations and lower detection limits,” said August Specht, Vice President, Research and Development, Chromatography and Mass Spectrometry, Thermo Fisher. “In order to protect consumer and environmental health, laboratories need to provide comprehensive workfl ows to address evolving requirements, and the TSQ Plus triple quadrupole MS portfolio has been designed to deliver.”


Professor Julijana Ivanisevic, University of Lausanne, said: “The TSQ Altis Plus platform is a step forward toward omics-scale, quantitative MS-based methodology for in-depth investigation of metabolism. The unprecedented acquisition speed of the TSQ Altis Plus allows us to maximise the metabolome coverage and signifi cantly enhances the peak defi nition, essential for accurate quantifi cation. The TSQ Altis Plus mass spectrometer allows for robust quantifi cation of low abundant species, thus complementing the comprehensiveness of measured metabolite signature. This increase in productivity, along with the quantitative aspect, is crucial for metabolic phenotyping of human populations - a prerequisite for the transfer to clinical settings.”


Users of the TSQ Plus triple quadrupole MS portfolio will benefi t from: increased system uptime due to enhanced quadrupole mass stability; direct instrument method transfers from the existing Thermo Scientifi c TSQ MS portfolio to the TSQ Plus MS portfolio, enabling simplifi ed transfers; integration with mzCloud database to provide Selective Reaction monitoring (SRM) transition information with predicted collision energy; integration with industry-leading liquid- and ion-chromatography systems and software, delivering powerful quantitative application solutions.


More information online: ilmt.co/PL/z2ly 56202pr@reply-direct.com


INTERNATIONAL LABMATE - APRIL 2022


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