49 Biotechnology & Immunology New Omicron Reactive Antibodies
Most of us are aware that the Omicron variant of the SARS-CoV-2 virus possesses multiple mutations in the Spike protein. However, this variant also has mutations in the nucleocapsid protein (N) as well.
This is critically important since current antigen tests detect the nucleocapsid by immunoassay. The antibodies employed in these tests must recognise the mutated N antigen otherwise a false negative test will result.
Leading infectious disease antigens and antibodies manufacturer, ViroStat, has validated their 4 best monoclonal antibody pairs (products #3865- #3868) for reactivity with the nucleocapsid of the Omicron variant. These high affinity antibody pairs are used successfully in lateral flow and ELISA applications for antigen detection of the other variants as well.
Download the updated data sheet for these antibodies. More information online:
ilmt.co/PL/2p1y
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Joint Research Project to Examine Regulatory T Cell Dysfunction in Autoimmunity and Infl ammaging
A German independent research institute, BioMed X, announces today the start of its new research project ‘Regulatory T Cell Dysfunction in Autoimmunity and Inflammaging’ (TDA) in collaboration with Merck KGaA, Darmstadt, Germany. The main objective of the research group TDA is to understand the molecular mechanisms governing immune senescence and metabolic dysfunction in regulatory T cells and other T cell subsets that are shared in autoimmunity and aging.
Group Leader of team TDA, Dr Gorjana Rackov, explained: “Regulatory T cells (Tregs) are crucial for maintaining self-tolerance and preventing autoimmune disease. During aging, cellular senescence of Tregs and their dysfunctional state may contribute to age-related diseases fuelled by chronic inflammation in the elderly - also called ‘inflammaging’.
Our goal is to improve patient outcomes by delivering new targets and novel therapeutic approaches for autoimmune disease treatment and for balancing immune responses in the elderly”, added Rackov, who holds a PhD in molecular biology. Before joining the BioMed X Institute in Heidelberg, Rackov worked as a postdoctoral researcher at the National Centre for Biotechnology (CNB) in Madrid, which forms part of the Spanish National Research Council (CSIC).
The start of team TDA underlines the ongoing successful collaboration of the partners since the inception of the BioMed X Institute in Heidelberg, Germany, in 2013. With four research projects already successfully completed, team TDA will join the three ongoing research groups sponsored by Merck KGaA, Darmstadt, Germany: two in oncology (RNA Splicing in Cancer, Synthetic Lethality in DNA Repair) and one in immunology (Intestinal Epithelial Barrier in Autoimmune Diseases).
Christian Tidona, Founder and Managing Director of the BioMed X Institute: “The next big frontier in immunology research is understanding human disease biology in the context of human tissue microenvironment and at the level of single cells. This new project allows us to further deepen our expertise in immunology research and to lay the groundwork for new therapeutic concepts for the treatment of chronic inflammation in autoimmune patients and the elderly.”
More information online:
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ADVERTORIAL Single Channel Pipetting Module Automates Tedious Repetitive Tasks
Integra Biosciences has created the D-ONE single channel pipetting module for hands-free transfers from individual tubes or wells using the ASSIST PLUS pipetting robot. This system effectively automates tedious tasks such as serial dilutions, sample normalisation, hit picking or pipetting of complex plate layouts, increasing productivity and reproducibility in the lab while reducing hands-on time, processing errors and physical strain.
The D-ONE is available in two volume ranges - from 0.5 to 300 µl and 5 to 1250 µl - to ensure optimal pipetting performance across a wide volume range. Each D-ONE module has two separate pipetting channels, using 12.5 and 300 µl or 125 and 1250 µl GripTips for high and low volumes respectively. The D-ONE pipetting module senses the liquid level immediately before aspiration, and is compatible with all Integra GripTips used for benchtop pipetting devices. This avoids the need for special tips, and saves time during program set-up. Combined with a specially designed D-ONE tip deck that can accommodate two tip racks, this allows the ASSIST PLUS to automatically switch between the different GripTips without tedious manual intervention, offering longer walk-away times.
The combination of the D-ONE and ASSIST PLUS ensures accurate and reproducible results every time by successfully automating dilution calculations for normalisations, hit picking without any transcription errors, and master mix preparations for varying sample numbers and volumes. This makes the D-ONE the perfect add-on for labs that want to go beyond the possibilities of multichannel pipetting to access unlimited applications on the ASSIST PLUS.
A simple tool for a crazy task HIT PICKING
Worry- and handsfree with the ASSIST PLUS Pipetting Robot and D-ONE Single Channel Module
Visit the Integra Biosciences website to learn more about the D-ONE single channel module, and to request a demo or quote.
More information online:
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D-ONE - Single Channel Pipetting Module
VIAFLO - Electronic Pipettes
VOYAGER - Adjustable Tip Spacing Pipettes
integra-biosciences.com
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