Environmental Laboratory


Mass Spectrometer Combining High Throughput, High Resolution and High-Energy


Advanced Ion Mobility-Enhanced Research Mass Spectrometer


Waters Corporation (USA) recently unveiled the new Waters SYNAPT G2-Si Mass Spectrometer at the 61st conference of the American Society of Mass Spectrometry (ASMS). The company is also previewing its UNIFI CCS Research Edition and the new TransOmics Version 2.0 informatics products for the new SYNAPT G2-Si mass spectrometer and demonstrating their benefits for a variety of small molecule applications and cutting-edge Omics-focused research.


Shimadzu (Germany), one of the world specialists in analytical instrumentation, introduces the new MALDI-7090 MALDI TOF-TOF mass spectrometer targeted for proteomics and tissue imaging research. The combination of Shimadzu’s extensive MALDI-TOF-TOF expertise with novel patented technology provides the MALDI-7090 with ultimate capabilities for identification and structural characterisation of biomolecules.


Innovative technology incorporated into the MALDI-7090 such as ASDF - Axial Spatial Distribution Focussing, delivers market leading high resolution MALDI MS/MS for accurate compound characterisation. This, in combination with proprietary solid state laser technology, true 2 kHz acquisition speed in all modes (MS and MS/MS), an integrated 10-plate loader and newly designed MALDI Solutions software, sets a new benchmark in MALDI TOF-TOF design.


Assistant professor Takeshi Kawamura from RCAST, University of Tokyo commented “The 2kHz laser speed and high MS/MS resolution in the MALDI- 7090 has accelerated our research in proteomics analysis for protein complex and histone modification using LC-MALDI”


Furthermore, the 20keV high energy CID capability of the MALDI-7090 efficiently produces additional fragment ions to further enhance characterisation. When commenting on the value of high-energy CID and high resolution MS/MS capabilities of the MALDI- 7090, Professor Guenter Allmaier from the Technical University of Vienna said “High-energy CID is the only way to locate double bonds in compounds containing fatty acids without any derivatisation - e.g. of triglycerides in plant oils used as food or corcins (color responsible structures) isolated in saffron. Data interpretation for structure elucidation of such high- energy CID spectra without isotopic resolved fragment ions is very hard to achieve.”


Comprising a powerful range of tools for method development, acquisition, data processing and interpretation, MALDI Solutions software allows automatic and manual control of the MALDI-7090 and has been designed to provide a flexible platform in the hands of both novice and expert users. Targeted software modules within MALDI Solutions address a wide variety of research applications such as proteomics and tissue imaging amongst others.


Commenting on the launch of the MALDI-7090 Mr Kozo Shimazu, Managing director of Kratos Analytical wholly owned subsidiary of Shimadzu Corporation, stated “We are very proud to announce the release of the MALDI-7090 at ASMS 2013. This newly designed MALDI TOF-TOF mass spectrometer broadens the Shimadzu MALDI product portfolio into the high performance high- throughput research field. The MALDI-7090 is the perfect complement to our AXIMA range of MALDI TOF and MALDI-QIT TOF instruments which already provide MS, MS/MS and MSn capabilities.


The MALDI-7090 offers ultimate sample throughput with high energy CID and high resolution MS/MS. This introduction forms an integral part of Shimadzu’s comprehensive mass spectrometry range of LCMS, GCMS and MALDI TOF mass spectrometers”.


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The SYNAPT G2-Si System integrates a third dimension of resolution and separation power into a new suite of untargeted and targeted LC/MS/MS workflows. This powerful new tool gives researchers a means with which to gain a deeper understanding of molecular biology and disease mechanisms, to develop the next generation of healthcare treatments or chemical materials, or to screen food products or environmental samples for contaminants. The SYNAPT G2-Si mass spectrometer now combines the unique power of Travelling Wave (T- Wave) Ion Mobility Separations with new data acquisition and informatics technologies, and collision cross section (CCS) measurements to bring to the toughest analytical applications, unparalleled information and confidence at a level not possible by mass and chromatographic separation alone.


The SYNAPT G2-Si mass spectrometer is the first MS system to elevate CCS alongside retention time and mass to charge ratio (m/z) as a robust, reliable identification parameter in library-based screening.


SYNAPT G2-Si High Definition Mass Spectrometry


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CCS measurements have the potential to transform the way people screen for known compounds, because unlike parameters like retention time, CCS values are unaffected by different matrices and chromatographic methods, and give you a much higher level of confidence that you've found what you're looking for, said Dr. Severine Goscinny, Belgium Scientific Institute for Public Health, Brussels, Belgium. The SYNAPT G2-Si system exemplifies Waters continuing commitment to innovation in mass spectrometry and collaborating with researchers on their journey of exploration.


The collision cross section of a molecule is an important distinguishing feature that is directly related to its chemical structure and three-dimensional conformation in the gas-phase. Like molecular mass, this additional orthogonal property of a molecule (through the use of high-efficiency T-wave ion mobility technology) gives scientists increased coverage and clarity for profiling mixtures or gaining additional measurements with which they can investigate chemical structures or better confirm a molecule's identity.


Integrating separation by CCS into targeted and untargeted experiments through new high-definition data-directed-analysis (HD-DDA) and high definition multiple reaction monitoring (HD-MRM) modes brings compelling benefits to the most challenging qualitative and quantitative applications: Maximised time-of-flight (Tof) duty cycle and effective sensitivity - of up to 10x in MS/MS mode - for targeted discovery and quantitation; Improved LC/MS/MS efficiency with a 40% improvement in the numbers of proteins identified from an E. coli sample and the identification of more than 2,000 proteins from a HeLa sample; Routine ultra-sensitive MS/MS assays with the benefit of high resolution and accurate mass for targeted quantification experiments; Physical separation of interferences away from the molecule or transition of interest on the basis of their collision cross section for improved selectivity when working with very complex matrices; A new and faster 2.5KHz solid state laser combined with new software for improved spatial resolution (down to 15m) for cleaner mass spectral data and greater image throughput when performing experiments with MALDI imaging and T-wave ion mobility.


As evidence of the successful use of T-Wave ion mobility mass spectrometry for the research laboratory, the International Journal of Ion Mobility Spectrometry in February of this year published an exclusive, two-volume special edition series on T-Wave ion mobility featuring 13 scientific articles by some of the world's top scientists.


As the newest member of the SYNAPT family of mass spectrometers, the SYNAPT G2-Si system can separate individual isomers, conformers, and isobaric compounds; help determine sites of biotransformation; study structure at physiological concentrations; comprehensively profile complex mixtures and minimize false positives and negatives in screening experiments.


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New Generation of Tandem Mass Spectrometer


At the 2013 American Society for Mass Spectrometry Conference, PerkinElmer Inc. (USA) introduced the AxION iQT gas chromatography tandem mass spectrometer (GC/MS/MS). The AxION iQT system provides greater quantitative capabilities to that of a triple quadrupole, while quickly identifying compounds like a quadrupole time-of-flight (Q-TOF) at a rate of up to 500 compounds per second. The new mass spectrometer provides laboratories with easier to use technology, faster results, and more specific, selective data needed to make more accurate decisions faster.


"Global regulatory expansion is driving increased adoption of mass spectrometry as the technology provides greater sample insights for many industries," said Dusty Tenney, president of Environmental Health, PerkinElmer. "We've created a new category of mass spectrometry designed to be faster, smarter, modular and easy to operate and maintain that combines superior quantitative and identification performance into one instrument, making this latest generation of technology both user and budget friendly."


The Axion iQT GC/MS/MS solution is intuitive, enabling technicians who are not mass spectrometry trained to run their analyses easily and with confidence. The AxION iQT system is the first MS/MS technology that delivers automated method development tools to users, includes advanced application-centric software and provides easy maintenance due to its smart modular system. These unique features make the AxION iQT system a one-of- a-kind, easy to use MS/MS instrument that enables analytical labs to deliver highly specific and sensitive MS/MS results, quickly and for virtually any application.


The new system can thoroughly characterise and easily quantify compounds for a variety of applications, including the analysis of pesticides in food samples to ensure food safety and authenticity, quantitation of non-derivatised steroids, cholesterol and therapeutic drug monitoring in research applications, analysis of drugs in forensic toxicology, and thorough analysis of chemical compositions.


At the ASMS conference PerkinElmer also announced a new collaboration with CTC Analytics to provide AxION Sample Manager, a complete sample preparation and analysis solution. The AxION Sample Manager is built around the industry-leading CTC PAL technology and can be integrated with the AxION iQT for automated sample preparation with unprecedented precision and repeatability.


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