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UK Company ensures Safety of Purified Water for Production in China’s National Vaccine Production Base
UV disinfection specialist Hanovia has supplied three UV water disinfection systems to the Institute of Medical Biology of the Chinese Academy of Sciences in Kunming. The PharmaLine PQL units destroy any unwanted microorganism in the purified water used in the production of vaccines. Moreover, these systems can display the verified ultraviolet irradiation dose online, further reducing the risk of microbial contamination.
The Institute of Medical Biology is the largest oral, anti-poliomyelitis vaccine production base in China. Since the 1960s it has produced over 5 billion vaccines for the National Planned Child Immunization programme in China. It is also the largest Chinese base for the development of Hepatitis A vaccines.
Because the Institute has always had very strict quality controls of its production process, when a new production facility was built in 2013 the Institute opted for Hanovia’s PharmaLine PQL UV technology.
Commenting on the Hanovia equipment, Shen Feng, the senior engineer and water treatment equipment expert at the Institute, said, “Compared with other UV disinfection systems, Hanovia’s PharmaLine PQL offers validated disinfection that has been certified by an independent third party. It also displays the UV dose online, meeting the stringent requirements of the pharmaceutical industry for verification and risk management.”
Purified Water has had almost all electrolytes removed, making it as inert as possible. The removal of any potential microbial contamination is of course also vital. Purified Water is an essential raw material for the production of vaccines and indicators (TOC, bacterial endotoxins, microorganisms, pH and conductivity) are strictly required in the pharmacopeia of many countries. Of these indicators, all but microorganisms and bacterial endotoxins can be controlled by water preparation technology.
UV kills 99.9% of the microorganisms, ensuring the concentration in purified water remains at an extremely low level (≤5cfu/ml). UV also does not produce any unwanted disinfection by-products that might contaminate the purified water downstream.
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New Generation Particle Size and Shape Analyser
The new CAMSIZER P4 from Retsch is the systematic enhancement and optimisation of the well-proven CAMSIZER system for the determination of particle size and particle shape with Dynamic Image Analysis. Based on the unique dual camera technology the new generation offers improved performance and extended functionalities.
Compared to the previous model, the CAMSIZER® P4 boasts faster cameras with higher resolution, a stronger light source and new
software features, resulting in even faster measurements and an extended measuring range. The improved resolution allows for more precise particle characterisation, particularly of small particles.
Both hard- and software have been revised. The software offers additional evaluation possibilities, such as separate storage of all particle images in a data base or 3-dimensional display of measurement results as scatter plots (3D cloud). New shape parameters for roundness and sphericity allow for optimised shape characterisation.
Well-proven functions like the certified calibration standard, the automated air flow in the measurement zone, and the motorised funnel height adjustment have been preserved in the CAMSIZER®
24/7, and can exactly reproduce existing sieving results.
Better performance, more functions: higher resolution of cameras and objectives permits more precise measurements of particle size and particle shape (20 µm – 30 mm); faster hard- and software record more particles per second and provide more detailed information; 3D cloud: Easy evaluation of particle morphology thanks to 3D display of measurement parameters; particle library: Direct storage of images of individual particles; convenient administration of new particle library.
30590pr@reply-direct.com P4. The obtained measurement results are accurate and reliable, even if operated
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