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Report on AFM System use to Study the Properties of Materials on the Nanoscale
Dr Peter Dunstan is an Associate Professor in the Department of Physics at Swansea University and a member of the University’s Centre for Nanohealth. His research utilises state of the art techniques and instrumentation to increase the fundamental understanding of the structural, chemical, optical and electronic properties of materials on the nanoscale, and by doing so advance the future application of those materials.
Asked why AFM is an important technique in his research, Dr Dunstan said: “AFM based systems give us the opportunity of generating a clear understanding of the structure of the materials that we investigate. AFM can also offer us the opportunity to correlate this structural measurement with other characteristics. For instance, by coating an AFM probe with gold and utilising the interaction between the metallised tip and a sample, it allows us to exploit an optical antenna effect when the tip is illuminated by an externally focussed laser of a suitable wavelength. This arrangement allows us to simultaneously correlate an enhanced localised spectroscopic response from the sample, along with the normal AFM response, and in doing so advance the application of the AFM instrument in line with our research objectives.”
Dr Dunstan is well placed to comment on the advantages he sees in the NanoWizard® system. “One major aspect of the benefits of using JPK has been
their ability to embrace our own research innovations and hence allow us to integrate our technology advances into the JPK instrument. This has allowed us to retain the advances we have made and integrate them onto the stable JPK AFM platform for improved performance. Also partnership with other companies has been important and is an area where JPK showed tremendous willing for cross-platform integration. Most recently, we published a paper in the Journal of Raman Spectroscopy on the use of TERS, tip-enhanced Raman spectroscopy, where we combined our JPK AFM and Renishaw Raman spectrometer to enhance lattice defect signatures in graphene.”
”It is important to mention we have benefited from the keen commitment of JPK staff to help us develop specialised adapted software approaches for our instrument when performing tip-enhanced spectroscopies and this has allowed us the precise control in the acquisition parameters that we require.”
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Collaboration to Accelerate Translation of Multiplexed Methods to Quantify Type 2 Diabetes Markers Announced
Scientists at Nuclea Biotechnologies, Inc and Thermo Fisher Scientific are pooling their expertise to develop novel multiplexed research methods for high-throughput quantification of native insulin and its therapeutic analogues. Monitoring the levels of these markers may be useful in predicting the response to therapy for Type 2 diabetes.
Nuclea has extensive experience in developing and commercialising biomarkers and clinical tests. The Thermo Fisher Scientific Biomarker Research Initiatives in Mass Spectrometry (BRIMS) Center has successfully collaborated with numerous leading clinical researchers to apply mass spectrometry (MS) to biomarker discovery and its translation to high-throughput, quantitative methods.
“We’ve already worked with the BRIMS Center to develop two other very important assays,” said Nuclea CEO, Patrick Muraca. “These assays have demonstrated the sensitivity, precision and robustness needed for high- throughput detection of clinically relevant isoforms of target proteins.”
“The real-world application of multiplexed MS-based methods to Type 2 diabetes presents an opportunity to advance research in this crucial area.” said Mary Lopez, Director of the BRIMS Center, Thermo Fisher Scientific. “Nuclea’s proven ability to validate and develop routine assays means our collaboration can support research efforts.”
Scientists from Nuclea and the BRIMS Center will develop multiplexed MS-based research methods that Nuclea will use to analyse donor plasma samples from Boston-based diabetes research collaborations. A proprietary platform that combines Thermo Scientific MSIA immuno-enrichment technology, TSQ Vantage or Quantiva triple quadrupole mass spectrometers and Pinpoint Software will be used for the collaborative work.
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