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New 5th Generation Benchtop X-ray Diffractometer
The new 5th generation MiniFlex from Rigaku is a general purpose X-ray diffractometer that can perform qualitative and quantitative analysis of polycrystalline materials. MiniFlex is now available in two variations. Operating at 600 watts (X-ray tube), the MiniFlex 600 is twice as powerful as other benchtop models, enabling faster analysis and improved overall throughput. Running at 300 watts (X-ray tube), the new MiniFlex 300 does not require an external heat exchanger.
Ideally-suited for today’s fast-paced XRD analyses, the MiniFlex delivers speed and sensitivity through innovative technology enhancements such as the optional D/teX high speed detector coupled with the new 600W X-ray source. If resolution is paramount, incident and diffracted beam slits can be selected to provide the desired resolution.
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Acquisition of REIMS Technology Strengthens Health Science Initiative
Waters Corporation have announced the acquisition of Rapid Evaporative Ionization Mass Spectrometry (REIMS) technology from MediMass Ltd. The REIMS technology represents substantially all of the assets of MediMass and includes patent applications, software, databases and REIMS expertise.
REIMS is the enabling technology for the ‘Intelligent Knife’ or ‘iKnife’, a device in the conceptual stages of development that could potentially be used for real-time diagnostics in surgery. Waters is committed to exploring the viability of this application in accordance with all applicable regulatory requirements. To date, no regulatory approvals have been sought for this device.
Waters’ experience with REIMS technology stems from a three-year collaboration among Waters, MediMass and Imperial College London focused on advancing REIMS. The goal of this relationship has been and continues to be advancing REIMS technology capabilities for health science applications.
REIMS is an ionisation technique that can be used as a source for direct analysis of samples by mass spectrometry. To date, REIMS technology has shown the ability to bring ambient ionisation sampling into real world applications such as food safety, microbiology and clinical diagnostic applications.
The transient nature of the REIMS signals is ideally suited for Waters’ time-of-flight mass spectrometers. A REIMS ion source will be made commercially available to complement the current range of ionisation sources on Waters Universal Ion Source platforms.
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Reaction Monitoring Experiments for Benchtop NMR Spectrometers Announced
The Magritek Spinsolve high-resolution benchtop NMR spectrometer can be installed directly in a fume hood of a chemistry lab to monitor the progress of chemical reactions on-line. Reactants can be pumped in continuous mode from the reactor to the magnet and back using standard PTFE tubing.
The reaction itself can be carried out at temperatures of up to about 100°C. When the reaction mixture is pumped through the bore of the magnet using 2 mm o. d. PTFE tubing, it naturally cools down to 30°C or lower as it flows along the length of the tubing at room temperature. For reactions where maintaining the elevated temperature is critical, Magritek has put together a simple but effective flow set-up for on- line monitoring. It comprises a Dewar of 5 mm o. d. and 2.25 mm i. d. that is mount ed in the bore of the Spinsolve to minimise any heat transfer from the flowing sample to the magnet. The pump, which can be set to operate in continuous or stop-flow mode to acquire points with a time resolution of about 15 seconds, is placed in the flow-loop after the magnet in order to minimise the tubing length that goes from the reactor to the sensitive volume of the Spinsolve.
This approach to reaction monitoring has been demonstrated on a number of classical chemical reactions. For example, acetalisation is a common reaction in organic synthesis where an acetal is produced from an aldehyde and an alcohol. In the example here, acetaldehyde reacts with methanol to produce acetaldehyde dimethyl acetal. The reaction was performed in DMSO to prevent evaporation. With data being collected every fifteen seconds over a total period of one hour, the user could follow waterfall plots to show the decrease of acetaldehyde as it was used up together with the corresponding rise of the acetaldehyde dimethyl acetal.
These and many other reaction systems are described in the growing library of applications notes and case studies which are freely available for downloading from the Magritek website.
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