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Simplified Novel Microrna Target Validation System Co-Development
Sigma Life Science, the innovative biological products and services research business of Sigma- Aldrich®
, and SwitchGear Genomics, Inc recently
announced a joint project to develop and distribute a novel microRNA (miRNA) target reporter system.
Combining SwitchGear Genomics’ expertise with Sigma’s versatile lentiviral technology, these ready- to-use reporter vectors are expected to simplify miRNA target validation, enabling researchers to investigate gene regulation in a variety of biological pathways.
“This is a very exciting joint effort,” said Dr Nathan Trinklein, CEO and Co-Founder of SwitchGear Genomics. “We believe that combining unique technologies from SwitchGear Genomics with Sigma’s industry-leading lentiviral technology and production capabilities will enable researchers to study miRNA function and gene regulation on an unprecedented scale.”
The genome-wide collection of reporter vectors is expected to provide highly effective miRNA target validation without the need for time-consuming and laborious reporter cloning. Use of Sigma’s patented lentiviral technology is expected to allow the highly regarded SwitchGear GoClone™ miRNA target sets to be used in a broad range of cell types, including primary cells and stem cells.
“We are excited to partner with SwitchGear Genomics on the co-development of this unique vector system,” added Dr Supriya Shivakumar, Global Commercial Marketing Manager for Functional Genomics at Sigma Life Science. “By offering this novel reporter technology in a lentiviral format we are addressing specific customer needs and we believe we are helping to further fundamental understanding of gene regulation.”
Circle no. 145
Delivering reliable operation in demanding conditions, Fiberguide Industries introduces its new line of fused silica capillary tubing.
The new line of tubing has proven effective in a number of scientific applications including protein characterisation, small molecule and genetic analysis, proteomics, DNA sequencing and fragment analysis.
Fiberguide’s capillary tubing is manufactured from high purity synthetic quartz with a protective coating of polyimide. Applied to the outer surface of the tubing, polyimide has an upper temperature limit of 360ºC. A wide variety of standard I.D.’s are available, from 2µ to 700µ and O.D.’s from 90µ to 850µ. Non-standard sizes can also be manufactured by request.
Circle no. 146
Fused Silica Capillary Tubing
ADVERTORIAL The New Field FDO: FDO® 925 from WTW WTW, Weilheim, Germany, proudly presents the optical field D.O. probe FDO® 925 belonging to the IDS family of intelligent digital sensors.
The FDO® 925 is designed for use with the new MultiLine® digital portable instruments and is suited for field as well as for laboratory use (diameter 0.6” / 15.3 mm). With its extremely fast response (T99 < 60 s) and its bevelled membrane repelling air bubbles, it provides excellent signals for reliable measurements.
The new sensor relys on the technology of WTW’s proven on-line optical D.O. Sensor: Soft green light guarentees a long service life of the optical membrane. The exchangeable membrane cap bears a chip with factory calibration data which are readout by the MultiLine®
. In combination with the new digital MultiLine® portable instruments, the new FDO® 925 will re-define mobile D.O. measurement. Circle no. 147
SenTix®
F – A New
pH Electrode for Mobile Measurements
In the lab, pH electrodes are mostly used at constant temperatures. This doesn’t apply for electrodes in the field measurement.
They are frequently exposed to changing conditions of environment and samples which may lead to temperature effects from the reference system that can not be compensated for.
This is solved by WTW’s new SenTix® F
pH electrode. It has a modern iodine/iodide reference system that shows almost no temperature dependence.
With a ruggedness plastic shaft it is ideal for field use under any conditions.
The SenTix® F is available as an IDS
electrode for the new WTW MultiLine® multiparameter instruments too.
Circle no. 148 Circle no. 149
INTERNATIONAL LABMATE - AUGUST/SEPTEMBER 2010 - LABORATORY PRODUCTS
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