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Unilever Takes New Approach to Particle Sizing
Waxy semisolids, today the formulation vehicle for many pharmaceutical and personal care products, present a considerable challenge when it comes to particle size analysis, primarily because they are not liquid at ambient temperature. By taking a new approach to particle sizing for these materials using the Mastersizer 2000 system from Malvern Instruments, researchers at Unilever are now confident in their ability to make reliable measurements that are feeding back into improved product development, manufacturing and quality control.
“Particle size is a critical parameter that influences the quality and performance of many of our products,” said Mark Flanagan, Process Chemist at Unilever, “but measuring materials that are not liquid at room temperature has posed considerable problems. Our solution has been to place the Hydro 2000SM small volume sample dispersion unit for the Mastersizer 2000 in a high temperature waterbath. We have been fully supported in this by Malvern’s applications teams, who have helped to overcome the technical challenges involved. The result is that we can now achieve hot dispersion of semisolid samples, and generate truly reliable particle size measurements.”
This new and highly successful approach to particle size measurement in semisolids is significant for Unilever since it provides the company’s formulators and QC specialists with a tool for improved understanding and control of their products, and one that will also inform product development. The Mastersizer 2000 has become the laser diffraction system of choice in many industries thanks to its rapid measurement capabilities, accurate and reproducible analysis, broad measurement range and the flexibility to measure many different sample types. It is especially sensitive to changes in coarse particle fraction and is therefore an excellent tool for studying the sample instability that results from, for example, agglomeration, creaming or sedimentation.
Circle no. 149
Papers and Posters on Powder Characterisation
At the World Congress on Particle Technology (WCPT6), which this year took place from 26-29 April alongside POWTECH and TechnoPharm at the NürnbergMesse in Germany, members of the Freeman Technology team presented a series of papers and posters covering various aspects of powder characterisation. The company also exhibited as part of the Powtech show where the FT4 Powder Rheometer will be on display.
The FT4 is a universal powder tester that uses patented dynamic methodology, fully automated shear cells and several bulk property tests, including density, compressibility and permeability to quantify powder properties in terms of flow and processability. Correlating this data with processing performance enables users to optimise powder processes.
Podium presentations from the Freeman team at WCPT6 will discuss: ‘The application of advanced powder characterisation techniques to pharmaceutical Quality by Design protocols’ and ‘Evaluation of dry powder blending using Positron Emission Tomography and the relationship between powder bulk properties and process parameters’.
In addition, Dr David Morton of Monash University, Australia, will speak about work that involves the use of the FT4 Powder Rheometer to investigate ‘The influence of dry powder coating methods, including mechanofusion, on the flow properties of inhalable grades of lactose monohydrate’. In the poster sessions, Freeman Technology’s contributions will include ‘The quantification of particle shape and size using image analysis and its effect on the flow properties of various forms of lactose’ and ‘The characterisation of the physical properties of wet masses’.
Freeman Technology specialises in providing systems for measuring powder flow properties and has over a decade of experience in powder flow and characterisation.
Circle no. 150
FRITSCH Particle Sizing
ANALYSETTE 22 MicroTec plus – THE NEW GENERATION
ec plus –
We exhibit: Forum LABO & BIOTECH 2010 Hall 4 • booth No. D9 • 1. – 4. June 2010 Paris Expo • Porte de Versailles • Paris • France
Discover now the new ANALYSETTE 22 MicroTec plus – the compact all-round-laser for all typical applications. And the new
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ANALYSETTE 22 MicroTec plus –
measuring unit with NEW dry dispersion unit (left) and wet dispersion unit (right)
For laser particle size measurements convinced users worldwide rely on FRITSCH quality and experience – for the fast industrial application as well as in industry- and research laboratories. Find the complete FRITSCH Laser Particle Sizer range and a free sample measure- ment in three steps at
www.fritsch-laser.com. Or give us a call and get a personal consultation!
u a ap lab Circle no. 151
+ 49 67 84 70 138 ·
crolly@fritsch-laser.com FRITSCH. ONE STEP AHEAD.
FRITSCH GMBH · MILLING AND SIZING · INDUSTRIESTRASSE 8 · 55743 IDAR-OBERSTEIN · GERMANY · PHONE +49 67 84 70 0 ·
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