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Horiba Scientific ULTIMA 2 Series of ICP-AES Systems
Transmission Raman Probes API Content Uniformity of Pharmaceutical Tablets
This new application note describes the use of Transmission Raman spectroscopy for the determination of content uniformity in pharmaceutical tablets, not only for in initial formulation protocol development, but as a routinely usable PAT at-line method for QC.
The fact that conventional Raman only examines the surface, not the entire volume, has long prevented Raman spectroscopy from being considered as a serious candidate for content uniformity assessment. The new transmission-mode measurement geometry addresses this issue. This new sampling approach consists in exciting from one side of the sample while collecting the signal from the other side and hence provides the ability of NIR to examine a large volume of the sample with the specificity of Raman to yield excellent correlation with the current off-line destructive method. Moreover, the measurement can be completed in a few seconds or less.
The ULTIMA 2 ICP Series provides a variety of solutions for a laboratory. Based upon the best selling ULTIMA 2, which features the lowest detection limits available today using a single view radial plasma and the best optical resolution, there are two additional models. By adding a directly viewed simultaneous optical system one has the ULTIMA 2C, which provides a complete solution for a laboratory with the speed and flexibility required for many applications where the need for a short analysis time must not compromise instrument performance. The simultaneous system also provides excellent precision in the determination of major elements. And then there is the top-of-the-line in ICP-OES instrumentation, the ULTIMA 2CHR, which has the resolution necessary to offer the analytical performance necessary to achieve accurate results in even the most complex materials.
All of the ULTIMA 2 Series can use the new CLIP (Collection of Line Intensity Profiles). CLIP assists the analyst in the development of methods for high resolution sequential ICP-OES: no more solutions to prepare and no more profiles to acquire. The profile of each line is calculated according to the instrument configuration: focal length, slit combination, diffraction grating and order used. Only a few minutes are needed to select lines for every element.
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Ultra Fast Depth Profiling with the GD Profiler 2
For a free copy of the application note please contact us at
info-sci.fr@
horiba.com or come to see us at
www.horiba.com/scientific
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Sometimes you have to look below the surface
Transmission Raman, anew commercially available solution, has eleminated the problem of only examining the surface plaguing other optical techniques by measuring bulk properties such as composition uniformity of tablets and capsules, yielding excellent correlation with destructive gold standard techniques.
Contact us to see how Raman can finally really simplify and speed up your development and QC measurements.
Researchers from Material Science Departments. Whether you do research on corrosion, elaboration of coatings, or treatment of materials, the GD Profiler 2 from Horiba Scientific is the analytical companion tool you need. Ultra Fast Depth Profiling of materials and layers (conductive or non), determination of the chemical composition as a function of depth, simultaneous measurement of all elements (including H, O, N, C, Cl), follow up of diffusions, interlayer mixings, interfaces contaminations.
The instrument relies on the sputtering of the material by an RF plasma and the analysis of the sputtered species by an optical spectrometer. Recent published applications include Li batteries, ion implantation, thermal treatments, migration of species during treatment on Al, PVD coatings or the use of the instrument for sample preparation in SEM.
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INTERNATIONAL LABMATE - APRIL/MAY 2010 - ADVERTORIAL
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