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Clearly Better Mass Spec CLEARLYBETTER


THE LEADING EUROPEAN JOURNAL FOR ANALYTICAL SCIENCE APRIL 2010 - VOLUME 35 ISSUE 3 products | applications | software | services


LC/MS, GC/MS, ICP-MS and MassHunter Software MS solutions that match your lab’s analytical needs and budget.


With over 40 years of innovation and the industry’s largest installed base, Agilent’s best-in-class portfolio of MS technologies delivers what you expect from a mass spectrometry leader. And more. Superior analytical performance. 24/7 Agilent reliability to maximize uptime and productivity. And MassHunter software to make your MS analyses faster, easier and more productive with a single, consistent user experience across all your MS platforms. Learn why Agilent Mass Spec is clearly better at ww.agilent.com/chem/clearlybetter


Circle no. 100 © Agilent Technologies, Inc. 2010 Our measure is your success.


If you're looking for clearly better MS results, be sure to look at Agilent Technologies. With over 40 years of innovation and the industry’s largest installed base, Agilent’s best-in-class portfolio of MS technologies delivers what you expect from a mass spectrometry leader:


• superior analytical performance • 24/7 Agilent reliability to maximise uptime and productivity


• MassHunter software to make your MS analyses faster, easier and more productive with a single, consistent user experience across all your MS platforms


• end-to-end MS workflow solutions that help you generate better results, faster than ever


Learn why Agilent mass spec is clearly better at www.agilent.com/chem/clearlybetter Circle no. 100


In this Issue Chromatography & Spectroscopy


Renowned French Chromatographer, Jean-Louis Rocca Passes Away at 64


4


The Fascinating History of the Development of LC-MS; a Personal Perspective


Frank Pullen


LCMS: From Pharmacokinetics to Metabolomics Dr Florence Raynaud


16 6


4-23


Laboratory Products INTERNATIONAL LABMATE


Head Office - International Labmate Ltd Oak Court, Sandridge Park, St AIbans, Hertfordshire AL3 6PH, United Kingdom. Tel: +44 (0)1727 855574 • Fax: +44 (0)1727 841694 Email: info@intlabmate.com • sales@intlabmate.com ISSN 0143-5140


Publishers of: International Labmate, Labmate UK & Ireland, Lab Asia, Chromatography Today, International Environmental Technology, Asian Environmental Technology, Pollution Solutions, Petro Industry News and Measurement Analysis China


IT Solutions Publisher Michael H. Pattison


Director of Publications Marcus Pattison


michael@intlabmate.com marcus@intlabmate.com


European Director of Laboratory Publications Twan Heesakkers


North American Area Manager Carol Hardy


Director, Asia Pacific Marie Izzard


Area Managers John Hobbs-Morris Chris Jarvis Cindy Lei


Classified Sales Silvi Sutherland


Production Manager Gary Durham


twan@intlabmate.com carol@intlabmate.com mizzard@optusnet.com.au


johnm@intlabmate.com chris@intlabmate.com cindy@intlabmate.com


silvi@intlabmate.com gary@intlabmate.com


Assistant Production Manager Robert Battell


Layout Artist Matthew Cook


robert@intlabmate.com matt@intlabmate.com Editor Gwyneth Astles


Features Editor Tamsyn Cox


Contributing Editor Heather Hobbs


Finance Controller Chris Brown


Accounts Manager Jacky Page


Accounts Assistants Nikki Kaloczi Linda Hudson


Credit Control Patricia Rogers


Guide Manager Sam Jackson


Guide Assistant Rebecca Cummings


Reader Services Manager Sue Petts


Market Research Printed by Wyndeham Heron, Covers printed by Colt Press, Published by International Labmate Ltd


Published: January, February, April, May Buyers Guide, July, August, October International Labmate is distributed to scientists, technologists, laboratory technicians and environmentalists throughout the Europe and Middle East, free of charge. The publication has the support of leading suppliers of equipment in the region and is displayed at the major exhibitions and conferences in these markets to attract additional readership.


Subscriptions: FOR ONE YEAR; Outside Europe or the Middle East - $100. Cheques made payable to International Labmate Ltd Alternatively fill in the Buying Now/User card and tick the subscription box


In order to obtain information on any of the products included in this journal, please fill in the appropriate numbers on the Reader Reply card and post or fax it to us. Alternatively contact the company directly by email, phone or via the website.


Buying Now Scientific Instruments Survey: Should you use or be planning to buy scientific apparatus and would like to receive the latest available information, please return the appropriate card.


European Office: Twan Heesakkers - International Labmate Ltd Science Park 5644, 5692 EN Eindhoven, The Netherlands Tel: +31 (0)40 267 6850 Fax: +31 (0)40 267 6851 E-mail: twan@intlabmate.com


North American Office: Carol Hardy - International Labmate Ltd 6635 West Happy Valley Road, Suite 104, #505, Glendale, AZ 85310, United States Tel: +(1) 623-869-0184 Fax: +(1) 623-321-9200 E-mail: carol@intlabmate.com


Asian Office: Marie Izzard - International Labmate Ltd Peninsula Business Centre, Ground Floor, Suite 1, 20 Bungan Street, Mona Vale, NSW, 2103, Australia Tel: +61 (0)2 9979-6886 Fax: +61 (0)2 9979-9181 E-mail: mizzard@optusnet.com.au


Japan: Mr Koichi Ogawa - OTO Research Corporation Takeuchi Building 1 -34-12 Takatanobaba, Shinjuku-Ku, Tokyo 169, Japan Tel: (03) 3208 7821 Fax: (03) 3200 2889


Korea: Dong-Shik Chai, Dong-Myung Communications Inc 191-1. Pyungchang-Dong, Chongno-Ku , Seoul, 110-012 Korea Tel: 82 2 391 4254 Fax: 82 2 391 4255


International Labmate is published six times per annum in tabloid format. In addition a most comprehensive "Guide to Laboratory and Environmental Equipment" printed in A4 format. It incorporates companies, products and dealers, mailed in May/June.


Although every effort is made to ensure the accuracy of material published, International Labmate and its offices cannot accept responsibility for claims made by contributors, manufacturers or advertisers.


© All rights reserved by International Labmate Ltd. Reproduction in part or whole without written permission is strictly prohibited.


Drug Discovery & Pharmaceutical Analysis Tamsyn Cox


60


Particle Characterisation Tamsyn Cox


46


Safety & Hazard Containment Tamsyn Cox


38 gwyneth@intlabmate.com tamsyn@intlabmate.com heather@intlabmate.com


Contributing Editor - Separation Science Bernie Monaghan


bernie@intlabmate.com chris@labmate.net jacky@labmate.net


nikkik@labmate.net linda@labmate.net


patricia@labmate.net sam@intlabmate.com beckyc@intlabmate.com


sue@intlabmate.com Marstonbury Ltd


News & Views Heather Hobbs


24


PITTCON 2010 SHOW REVIEW Tamsyn Cox


26 Special Features


Near Infrared Transmission Spectroscopy in the Food Industry


John Bevan 56 Microscopy & Microtechnology 56-59 42-43 Malcolm Lee & Andrea Huber


The Ice-Bucket Makeover: Portable Laboratory Cooling Gets with the Times


Mr Schryver 52


24-55


Forensic Blood Analysis: New Approach To Determine Time Since Deposition Of Blood at Crime Scenes


34


Please look after the environment by recycling this magazine


COVER STORY


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