SHOW REVIEW


New Quaternary Pump Unveiled


New High-Resolution Stable Mass TOF Spectrometer


Unique Mobility Instrument


Thermo Fisher Scientific, Inc announced a new quaternary pump that dramatically improves separation for complex mixtures, such as red wine, during ultra-high pressure liquid chromatography (U-HPLC) analysis. The new Thermo Scientific Accela 1250 pump features Force Feedback Control (FFC) which eliminates the need for pulse dampening while improving flow accuracy and gradient precision under extreme operating conditions. The Accela 1250 pump is designed to operate at a top pressure of 1250 bar with flow rates of up to 2mL/min, reducing run times and improving productivity. This makes it the ideal choice for U-HPLC analysis and applications requiring flexibility between standard HPLC and U-HPLC capabilities. The improved pump also offers increased performance with significant baseline stabilisation and improved retention time reproducibility.


“We are delighted to bring enhanced U-HPLC to our customers,” said Andrew Altman, Director of Liquid Chromatography for Thermo Fisher Scientific. “The pressure capacity and operational performance offered by the Accela 1250 delivers maximum operating pressure, and the unique Forced Feedback Control redefines U-HPLC performance.”


The Accela 1250 pump enhances the already powerful Accela LC, which provides fast, efficient chromatographic separations over an expansive range of flow rates and pressures.


Circle no. 71


Zoex Corporation recently announced the FasTOF, a high resolution TOF mass spectrometer, specifically designed for comprehensive two-dimensional gas chromatography applications. The FasTOF is sold as a system bundle including the Agilent 7890 GC, the Zoex thermal modulator, and the Zoex HiResTOFMS module. FasTOF is equipped with a unique, patent pending mass calibration system. Calibrant material is pulsed into the ion source in synchrony with the GC x GC modulation cycle. This permits the mass scale to be fully recalibrated every few seconds throughout an analytical run, with no interferences between the calibrant material and analyte ions. The result is the most stable and accurate mass measurements: +/- 0.0007 Th (1 Thompson is approximately 1 amu) of any instrument in its class. Elemental composition assignments are routine with this instrument, which is targeted at complex mixture analyses in metabolomics, environmental forensics, flavors/fragrances, petroleum liquids, and other demanding applications.


Circle no. 72


Wyatt Technology Corporation announced the launch of its


Möbiuζ™ mobility instrument. The instrument incorporates several patent-pending innovations to realise fast and reliable measurements of macromolecular electrophoretic mobilities.


Besides being capable of swiftly measuring mobilities of large particles such as liposomes and VLPs, Wyatt Technology’s


Möbiuζ™ is the only laser-based instrument that achieves reproducible measurements of traditionally very challenging protein samples including antibody formulations, bovine serum albumin and lysozyme. It is designed specifically to address the unique measurement of protein mobilities rather than a remake of a device designed to measure particulates.


As well as being a non-invasive method, laser light scattering is prized for its ability to carry out physical, first-principle measurements of macromolecules’ electrophoretic mobilities. However, when it comes to proteins, satisfactory results have been difficult to come by due to their small sizes (<5 nm) and their more conspicuous Brownian motions. Lengthier measurements are therefore necessary to average out the mobility-masking diffusion and reveal the macromolecular electrophoresis.


New Real Time Raman Spectrometer


Spectrolab Systems UK showcased their latest Raman spectrometer, Laserspec 3000, at Pittcon. The all new spectrometer is many hundreds of times more sensitive than other commercial instruments and considerable interest is anticipated from both the military and pharmaceutical industry. The remarkable new optical system used in Laserspec Raman systems allow samples to be measured in mili seconds rather than minutes and is hundreds of times more sensitive than most other commercial instruments. The instrument is extremely rugged and can be used in the lab or at site out of doors making it the perfect instrument for multi use applications.


A series of application interfaces are available allowing Laserspec to be used as a spectroscopic detector and the latest interface allows the instrument to be used as a detector for HPLC. Chromatography has been waiting for decades for an inexpensive Raman detector allowing much needed molecular analysis to be made directly from an LC sample cell. The simple interface developed for chromatography allows Laserspec to be interfaced to practically any commercial chromatograph - old or new. Other interfaces allow use with other types of instrument including X-ray diffraction, Optical emission and Xray fluorescence. Combined IR or NIR and Raman is also available making Laserspec truly universal. SERS technology is available for ppb measurements offering a gain in sensitivity of around 100 million. Real time measuring capability means that spectral characteristics can be continuously monitored and correlated to changes in optical expression allowing dynamic or kinetic analysis to be made at a fraction of the price normally found in similar process instruments .


Circle no. 73 EXHIBITORS COMMENTS


In the process, these fragile molecules are subjected to electrical currents and often irreversibly damaged and degraded, rendering the results unreliable.


As the solution ionicity increases, the situation deteriorates because even more current is required to drive measurable electrophoresis. Existing products on the market notoriously ‘cook’ their protein samples and struggle to measure any macromolecule smaller than 5 nm at a reasonable concentration.


The key to the successful measurement of proteins’ mobilities lies in a much shortened measurement time and the availability of sufficient data to average away molecular


diffusion. Wyatt Technology’s Möbiuζ™ achieves these goals through massive parallelism of detection and extends the measurable molecular size range below 2nm. A reduced measurement time (<60 seconds in most cases) contributes to excellent preservation of precious and fragile protein samples.


Circle no. 74


Tom Levesque, Vice President, NanoInk


“Seemed to me that announcements of the demise of live conference has been premature – we had good booth traffic in addition to the opportunity to rub shoulders with competitors. The timing was good because we had our new NS500 instrument to launch, and given the growth in our sales team, we had a chance for a team meeting. This is the ideal time of year and within the budget cycle for that. I think our position was fortuitous; our small size allowed us to double sales last year, whilst the large instrument manufactures with significant share were adversely affected by a downturn.”


Jeremy Warren, Chief Executive, NanoSight Ltd


“This year’s Pittcon was very successful for Edwards. It was the 10th one I’ve attended and while the number of visitors to the stand has been less than previous years, the quality of leads has increased significantly. Edwards plans to attend next year. It’s the biggest scientific show in the US at present and is a key show on our calendar for meeting others in the industry and getting useful feedback from them. The make- up of the show has changed in the last 10 years and many of the more technical people from the larger OEMs no longer attend. However, a lot of the end user decision makers do attend and they wield some influence over the OEMs. I personally think Pittcon would be a much bigger and better show if it took place every other year.”


Brian Whitney, Key Account Manager, Edwards


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