Drug Discovery & Pharmaceuticals
Purifi cation of Pharmaceutical and Biotechnology Products with Kromasil EternityXT Stationary Phase
With excellent mechanical and chemical stability, the Kromasil EternityXT materials offer first-rate separation power and loadability for purification from low to high pH. Kromasil EternityXT C8 and C18 materials can operate up to pH 12, making it possible to run basic compounds under extreme conditions to improve purification productivity and reduce costs. These products support discovery, development and production departmental goals in the purification of a low molecular weight pharmaceuticals, peptides and biotechnology products.
The exceptional structure of Kromasil EternityXT C18 and C8 materials makes it possible to regenerate the material in-column, carrying out cleaning in place (CIP) even at 1 M NaOH, if so required. While this high concentration NaOH treatment is a standard in bio chromatography and until now only conceivable with polymer resins, Kromasil EternityXT materials open up the spectrum of purification options as its C8 and C18 materials resist up to 1 M NaOH.
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Ultra-Effective Mini-Mill Provides Fast, Loss-Free Grinding Results
The ultra-compact Fritsch Mini-Mill PULVERISETTE 23 is the ideal assistant for fine comminution of smallest quantities, for wet grinding as well as for dry or cryogenic grinding. Its special, spherical grinding bowl ensures much better performance in grinding, mixing and homogenising compared with similar models. With a footprint of just 20 x 30 cm and a weight of 7 kg, it easily fits anywhere. It’s smart, is extremely user-friendly, inexpensive, and convinces with impressive results.
The PULVERISETTE 23 is ideal for: chemical analysis - comminution and homogenisation of grinding samples for creation of compacts for x-ray fluorescence and infrared spectroscopy (e.g. potassium bromide tablets); environmental research - soils in contaminant analysis, humic acid determination, botanical materials in residue analysis of fertilisers and pesticides, pulping of seeds; pharmaceuticals and medicine - kidney and gallstone analysis, breaking up tablets, pharmaceutical ingredients; forensic analysis - hair analysis for genetic testing and drug tests, preparation of extremely small particles for chemical analysis, textile fibre and bone analysis; biotechnology - comminution of deep frozen tissue samples; material synthesis - creating mixtures for catalytic tests on polymers, ceramic analysis.
The 5 ml PTFE bowl is specially suited for using the Fritsch PULVERISETTE 23 in biotechnology applications. For example, it is possible to break up fungus or yeast cells, deep frozen tissue and cells in only a few minutes with this special plastic bowl and a 10 mm steel ball. It is also possible to pre-cool the entire bowl in liquid nitrogen.
In special consideration of the ball mill grinding concept, Fritsch developed a grinding bowl with interior walls that are spherical instead of cylindrical for the PULVERISETTE 23. This ensures unmatched grinding performance with a significantly improved grinding effect, much easier recovery and simpler cleaning. The spherical grinding bowls of the PULVERISETTE 23 are assembled simply and quickly, just twist and turn.
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Enhanced Pharmaceutical Metal Detector for Improved Operating Effi ciencies Launched
Lock Inspection, part of the Loma Group, has launched an enhanced version of its well proven Insight Pharmaceutical Metal Detector. Lock’s popular Insight PH system offers advanced detection performance, construction quality and reliability characteristics, making it an effective inspection solution for the high speed elimination of metal contaminants after the tablet press and de-dusting processes.
Utilising its unrivalled 68-year history and significant industry experience, Lock has developed the Insight PH to further improve stability and manoeuvrability, which allows easy integration with the tablet presses, de-dusters, polishers and encapsulation equipment commonly used by pharmaceutical and nutraceutical manufacturers.
The Lock Insight PH Metal Detector boasts a newly upgraded ‘H’ frame for improved stability designed to counteract the surrounding noise pollution that often causes false contaminant rejection and increased product wastage.
In addition, the frame now features durable locking caster wheels making it faster and simpler for operators to move and secure the metal detector between production lines. It is adjustable for height and angle of tilt using a gas strut and new clamping sleeve, allowing the unit to be quickly relocated and operational within minutes.
Plus the metal detector’s compact design allows it to be located on virtually any production or packaging line without disrupting the plant layout.
James Chrismas, International Pharmaceutical Business Manager at Lock Inspection commented: “Lock has enjoyed a long-standing relationship with the pharmaceutical industry and consistently helped major companies successfully anticipate and satisfy the quality assurance demands of regulatory authorities, retailers and manufacturers alike.
The system also offers ‘fully digital processing’ functionality for conversion of analogue signals to digital processing in the detection head. This eliminates interference from the various frequencies emitted by tablet presses and digital radios, for example. A voltage measurement read-out allows the customer to properly monitor calibration.
Lock’s Insight PH offers best in class calibrated detection levels of 0.25mmFE, 0.3mmNFE and O.4mmSt/St. Four password protected security levels are provided for operators, supervisors, engineering and administration. The system is available with fully documented Installation Qualification (IQ), Operational Qualification (OQ) and Performance Qualification (PQ) validations for compliance with FDA, GAMP and GMP specifications. It is design and construction compliant with 21CFR parts 10 and 11 and certified to NEMA 4X / IP66.
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