8 Smart Gas Generators Innovative HILIC Columns for HPLC and UHPLC


Hilicon is a leading company in developing and manufacturing chromatography products for HILIC separation of polar compounds. It has recently introduced a broad range of HILIC columns under the brand names of iHILIC®


-Fusion, iHILIC® -Fusion(+), and iHILIC®


LNI Swissgas, based in Geneva, Switzerland, is a leading organisation in gas calibrators, blenders, generators and linearisation systems.


The company develops, manufacture and sell products for Air Pollution Monitoring, Emission & Process, Automotive and Laboratories.


The product portfolio includes: High precision calibrators for gas applications, Hydrogen, zero air, and nitrogen 19” rack generators for APM and CEM, Hydrogen, zero air, and nitrogen generators for GC and LCMS applications, Ozone Generators for low concentrations and Permeation tubes.


LNI Swissgas maintains ISO 9001 for corporate activities, research and manufacturing. In order to satisfy high metrological requirements, LNI Swissgas, has been working for several years with its own accredited ISO 17025 calibration laboratory.


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The packed stationary phases are charge modulated amide silica or polymer particles that are covalently bonded with neutral, positively charged, and negatively charged hydrophilic functional groups, following Hilicon’s longtime experience in HILIC technology. Therefore, iHILIC columns provide tailor-made and complementary selectivity, excellent durability, and ultra-low bleeding, which improve the productivity and quality of chemical and biological analysis.


Beside the HILIC columns, Hilicon also provide HILIC type SPE cartridges (iSPE® -HILIC) for


solid phase extraction and purification of polar compounds from various sample matrix. The purification of glycan/glycopeptides or toxins are two of the most important applications.


For further information email info@hilicon.com or visit www.hilicon.com. 41706pr@reply-direct.com


-Fusion(P). These columns can be used in


the application areas, such as, ‘Omics’ research, pharmaceutical discovery, food and beverage industry, clinical diagnostics, and environmental monitoring.


New Initiative to Reconnect with Lost Generators Launched


Peak Scientific has launched a new initiative to update its national register of what is a considerable install base of gas generators across North America. The UK based manufacturer, now with a sizeable MA based US operation employing 50 people directly across the country, is on a drive to reconnect with end-users of their gas generators that may have previously been sold into North America through third party vendors.


New Chiral Column Offered


Millipore Sigma, through its collaboration with ES Industries, offers a number of innovative and unique selective chiral stationary phases designed to solve chiral applications. Chirality has become critically important in the pharmaceutical, chemical and agricultural industries. Due to subtle differences, compounds that exhibit chiral activity can produce dramatically different pharmacological effects in biological systems. As a result, the demand for stereo selective separation techniques and analytical assays to evaluate the enantiomeric purity of chiral compounds has increased. Chiral chromatography in the forms of HPLC and SFC has become a necessary tool; not only for the analytical determination of enantiomeric purity, but also for the


isolation and purification of enantiomers. As a leader in chiral separations, the ChromegaChiral products offer a broad range of Chiral Stationary Phases (CSP’s) for analytical and preparative chromatography needs. Existing CSP’s can separate a wide variety of chiral mixtures; however there are still enantiomeric mixtures that are difficult to separate limiting their characterisation. This provides the drive to develop new CSP’s with differing chiral selectivities, e.g. ChromegaChiral CCA-F4 a chiral phase with embedded Fluorine atoms.


The addition of a fluorine atom into a phenyl carbamate amylose structure can be useful in promoting fluorophilic retention mechanism which can provide improved retention for fluorinated compounds. A fluorophilic retention mechanism can be particularly useful in medicinal chemistry and drug discovery, where more than a third of newly approved small molecule drugs contain fluorine. ChromegaChiral CCA-F4 can be used in SFC or HPLC. Product features Include: excellent selectivity range; high pressure limit; wide range of applications; fast optimisation; superior resolution and efficiency; one column for bBoth SFC and HPLC use; easy scale-up from analytical to preparative columns.


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It is estimated that many hundreds of unregistered Peak generators are in laboratories across the US and are unlikely to be benefiting from direct Peak maintenance and after-sales care. An ‘unregistered’ generator is any generator which has not had its unique serial number and manufacturer warranty registered via the Peak Scientific website.


The company is running a promotional incentive to encourage users to register their Peak generators, with a gift voucher and monthly prize draw entry for the owners of any ‘lost generators’ that are found. Customers who register a qualified serial number at www. peakscientific.com/findme will receive a $35 Amazon voucher and be entered into a monthly prize draw to win an Amazon Echo. ‘Finders’ can also then take advantage of a promotional offer giving them ‘15 months for the price of 12’ on their first year with a Peak Protected service contract, on any generators they have not currently covered by Peak service.


Billy Myers, Chief Commercial Officer – Service, said of the initiative, “We are very excited about this initiative. Reconnecting with these generators will allow us to provide the exceptional on-site customer service that Peak is renowned for and keep our customers’ generators operating at their best.”


The Lost & Found initiative will run until end of June. For more details, visit the company website at www.peakscientific.com/findme 41729pr@reply-direct.com


Single-Compound Standards Improve the Analysis of Difficult Pesticides


Troublesome pesticides can be analysed more easily and accurately with single-compound standards from Restek. New individual standards are now available for dicofol, metribuzin, bromacil, lenacil, dodine, anilazine, captan, and folpet. Use these standards to simplify method development, establish instrument detection limits (IDLs), verify performance, test stability, and resolve degradation issues. Restek is your one-stop shop for accurate, reliable pesticides analysis and are the only reference standard provider that offers everything you need from sample prep to LC and GC columns and consumables.


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Challenges During mAb Purification


For purification of monoclonal antibodies, high demands are required from the separating material. Factors influencing the binding characteristics of IgG are pH, linear velocity and/or salt concentration (conductivity) at the time the sample is loaded onto the column. Therefore, a material with highly stable performance is required with regard to all those factors. In order to demonstrate the performance of YMC-BioPro materials, several studies have been performed. High binding capacities are achieved regardless of elution of pH. Therefore, milder eluting conditions for Adalimumab can be selected. BioPro SmartSep maintains higher binding capacity values over a wider range of linear velocity.


This will increase product throughput for the purification work without loss of ef ficiency. BioPro SmartSep has higher salt concentration tolerance. This simplifies the desalting pro cess after Protein A chromatography and will help to shorten the production process. BioPro SmartSep materials meet the highest demands for the purification of monoclonal antibodies. High binding capacity is achieved regardless of elution of pH, linear velocity or salt concentration. This allows purification processes to be carried out more efficiently.


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INTERNATIONAL LABMATE - APRIL 2017


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