drug you take, the more you have in your system). Tere are several studies discussing how drug metabolite
disposition varies among individuals and dosage levels. In the previously referenced manuscript by Dr. Marilyn Huestis and Dr. Edward Cone, the purpose of the study was to “review the disposition of methamphetamine in oral fluid, plasma and urine.”2
In the study,
they administered single and multiple doses of methamphetamine to 5 non-drug users. Te multiple dose study included Subject BB receiving sequential doses of 20 mg methamphetamine (given at 0, 24, 48 and 72 hours), as well as Subject S receiving non-sequential doses of 10 mg methamphetamine (given at roughly 0, 48, 72 and 144 hours). Although Subject BB ingested twice as much drug during the study, Subject S demonstrated considerably higher levels of methamphetamine in urine.
While this study focuses on the different detection times in oral fluid, plasma, and urine, it also shows that the disposition of drugs in bodily fluid is NOT necessarily directly proportionate to dosage or ingestion. Besides individual variations, concentrations of drugs in these liquid matrices are completely dependent on the time lapsed between ingestion and sampling, and therefore results can never be used to indicate the magnitude of the dose.
In Summary When constructing a program that ensures a drug-free workplace, it is always important to understand facts versus myths. Highlighted above are just some of the common myths in the industry. It is always a good idea to reach out to your drug testing professionals to get the most up-to- date information and to ensure that your program is not being influenced by any of these or other common misconceptions.
References 1
Colorado Supreme Court case number 2015 CO 44 No. 13SC394, Coats v. Dish Network, LLC.
2
Huestis, M. A. and Cone, E. J. (2007), Methamphetamine Disposition in Oral Fluid, Plasma, and Urine. Annals of the New York Academy of Sciences, 1098: 104–121. doi: 10.1196/annals.1384.03
Duffy Nabors is a National Account Manager for Psychemedics Corporation (
www.psychemedics.com). With over 18+ years of sales experience which includes
selling instant oral fluid and urine tests as well as lab based hair testing, he consults with businesses regarding how to implement and maintain the most effective drug screening program to increase their productivity and efficiency. This article is a continuation of a series of articles that Duffy began writing while employed at Express Diagnostics.
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